Cord Blood News Volume 11.11 | Mar 28 2019

TOP STORY

Improved Expansion of Equine Cord Blood Derived Mesenchymal Stromal Cells by Using Microcarriers in Stirred Suspension Bioreactors

Researchers outlined the development of an expansion bioprocess, detailing the inoculation phase, expansion phase, and harvesting phase, followed by phenotypic and trilineage differentiation characterization of two equine cord blood-derived-MSC donors. [J Biol Eng] Full Article

(Ranked by impact factor of the journal)

Determining the Extent of Maternal-Fetal Chimerism in Cord Blood

Investigators aimed to functionally characterize maternal T cells from cord blood (CB). They could not isolate viable maternal cells from CB even after using state-of-the-art enrichment techniques that allowed detection of viable cells in heterologous populations at frequencies that were several orders of magnitude lower than reported frequencies of maternal T cells in CB. [Sci Rep] Full Article

Exosomes Derived from Umbilical Cord Mesenchymal Stem Cells Reduce Microglia-Mediated Neuroinflammation in Perinatal Brain Injury

Human Wharton’s jelly-MSC-derived exosomes dampened the lipopolysaccharide (LPS)-induced expression of inflammation-related genes by BV-2 microglia and primary mixed glial cells. The secretion of pro-inflammatory cytokines by LPS-stimulated primary mixed glial was inhibited by exosomes as well. [Stem Cell Res Ther] Full Article

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Promote Fibroblast-to-Myofibroblast Differentiation in Inflammatory Environments and Benefit Cardioprotective Effects

The authors investigated whether human umbilical cord MSC-exosomes promoted cardiac fibroblast-to-myofibroblast differentiation in inflammatory environments and protected cardiomyocytes. [Stem Cells Dev] Abstract

A Comparison of Hematopoietic Stem Cells from Umbilical Cord Blood and Peripheral Blood for Platelet Production in a Microfluidic Device

Researchers compared and characterized platelets produced in shear flow using precursor cells from either umbilical or adult peripheral blood. [Vox Sang] Full Article

Umbilical Cord Blood-Derived Helios-Positive Regulatory T Cells Promote Angiogenesis in Acute Lymphoblastic Leukemia in Mice via CCL22 and the VEGFA-VEGFR2 Pathway

Scientists revealed that umbilical cord blood‑derived Helios⁺ regulatory T cells (Tregs) had proliferation and immunosuppression abilities similar to those of normal pediatric Tregs. [Mol Med Rep] Abstract

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Characterization of Human Natural Killer Cells for Therapeutic Use

The authors discuss a comparative assessment strategy, from characterization of natural killer cells at collection to final product release by various phenotypic and functional assays, in an effort to predict potency of the cellular product. [Cytotherapy] Abstract

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Phio and Glycostem to Collaborate on Use of Its sd-rxRNA^® Platform and Glycostem’s oNKord^® Cell Therapy Products for the Next Generation of Natural Killer Cell-Based Immunotherapy for Cancer Treatment

Phio Pharmaceuticals Corp. announced that it has entered into a research collaboration with Glycostem Therapeutics BV to explore the potential synergies of using Phio’s self-delivering RNAi technology in combination with Glycostem’s proprietary Natural Killer-cell generation technology to develop cellular immunotherapies for cancer treatment with enhanced efficacy and/or safety. [Phio Pharmaceuticals Corp.] Press Release

Mogrify Awarded $555,000 USD Innovate UK Funding to Accelerate Regenerative Cell Therapies

Cell Mogrify Ltd announced that it has been awarded $555,000 USD funding from Innovate UK through the investment accelerator for innovation in precision medicine. [Cell Mogrify Ltd] Press Release

NIH May Bar Peer Reviewers Accused of Sexual Harassment

The National Institutes of Health (NIH) in Bethesda, Maryland, reminded the research community this week that the agency can—and sometimes does—bar scientists accused of sexual harassment from serving as peer reviewers. [ScienceInsider] Editorial

Top US Institutes Still Aren’t Reporting Clinical-Trial Results on Time

Many leading US universities are breaking the law by failing to make public the results of clinical trials. A report found that 25 of the 40 universities that sponsor the most trials in the United States did not post study results on a public, government register within 12 months of completion, as is required by US law. [Nature News] Editorial

As Elsevier Falters, Wiley Succeeds in Open-Access Deal Making

Over the last few years, Project DEAL, a consortium that represents around 700 academic institutions in Germany, has been in negotiations for nationwide licensing agreements with three of the largest scholarly publishers—Elsevier, Springer Nature, and Wiley. [The Scientist] Editorial

NEW Gordon Research Conference: Red Cells: Erythropoiesis & the Erythrocyte
July 14-19, 2019
Newport, Rhode Island, United States

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NEW Postdoctoral Position – Mechanobiology (The University of Texas Health Science Center at Houston)

Postdoctoral Position – Hematopoietic Stem Cells (Washington University School of Medicine)

Postdoc Fellow Positions – Human iPS cells, Epigenetics, Hematopoietic Stem Cell Biology, and Blood Cancers (Nationwide Children’s Hospital & Ohio State University)

Tissue Bank Technician – Hematology (University of Oxford)

Laboratory and Clinical Studies Manager – Hematology (University of Oxford)

Postdoctoral Position – Stem Cells and Erythropoiesis (Karolinska Institutet)

Assistant Professor – Computational Biology/Stem Cell Biology (University of Illinois at Chicago)

Postdoctoral Scholarship – Proteomics and Erythropoiesis (Lund University)

Postdoctoral Position – Experimental Hematology (Leipzig Universitätsklinikum)

Postdoctoral Research Fellow – Development of Lymphoid Cells (Lund University)

Faculty Positions – Cancer Research (Shenzhen University)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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