Cord Blood News Volume 11.12 | Apr 4 2019

TOP STORY

G‐CSF Administration Prior to Donor Lymphocyte Apheresis Promotes Anti‐Leukemic Effects in Allogeneic HCT Patients

The granulocyte colony‐stimulating factor (G‐CSF) donor lymphocyte infusion patient cohort showed an improved conversion to full donor chimerism and a lower cumulative incidence of relapse or disease progression without a significantly increased cumulative incidence of graft‐versus‐host disease. [Br J Haematol] Abstract

(Ranked by impact factor of the journal)

Influence of Donor and Recipient Gender on Telomere Maintenance Following Umbilical Cord Blood Cell Transplantation: A Study by GITMO

Telomere length (TL) dynamics were analyzed on peripheral blood mononucleated cells from 36 patients undergoing umbilical cord blood transplantation (UCB-T). TL was studied at a median of 20 months since UCB-T. [Biol Blood Marrow Transplant] Abstract

Accumulating Transcriptome Drift Precedes Cell Aging in Human Umbilical Cord‐Derived Mesenchymal Stromal Cells Serially Cultured to Replicative Senescence

Researchers sought to define the maximum expansion boundaries for human umbilical cord‐derived MSCs, cultured in chemically defined xeno‐ and serum‐free media, that yielded consistent cell batches comparable to early passage cells. [Stem Cells Transl Med] Full Article

Combination of Cord Blood‐Derived Human Hepatic Progenitors and Hepatogenic Factors Strongly Improves Recovery after Acute Liver Injury in Mice through Modulation of the Wnt/β‐Catenin Signaling

In vivo, the authors analyzed the effect of human hepatic progenitors on damage recovery and functional regeneration in a mouse model of acute liver injury, either in combination or in absence of a selected mix of hepatogenic factors. [J Tissue Eng Regen Med] Abstract

Pharmacokinetic and Pharmacodynamic Study of Lenograstim for Hematopoietic Stem Cell Mobilization: A Prospective Randomized Study for Optimal Apheresis

Investigators evaluated the correlation between the pharmacokinetics and pharmacodynamics of granulocyte colony‐stimulating factor and the impact of initiation time of apheresis on stem cell mobilization in patients with multiple myeloma. [Transfusion] Abstract

Suppressive Characteristics of Umbilical Cord Blood-Derived Regulatory T Cells after Ex Vivo Expansion on Autologous and Allogeneic T Effectors and Various Lymphoblastic Cells

Scientists investigated the direct effects of umbilical cord blood (UCB)-regulatory T cells (Tregs) on the proliferation of autologous T effector cells (Teffs), as compared with allogeneic Teff, and also determined cellular fates of lymphoblasts after UCB-Treg co-culture. [J Immunother] Abstract

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Current Understanding of the Immunosuppressive Properties of Mesenchymal Stromal Cells

The authors shed light on current knowledge regarding the mechanisms by which mesenchymal stromal cells (MSCs) exert immunosuppressive effects both in vitro and in vivo, focusing on the receptors expressed by MSCs, the correlation between soluble factors secreted by MSCs and their immunosuppressive effects, and interactions between MSCs and immune cells. [J Mol Med] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Orgenesis Signs Master Service and Joint Venture Agreement with TheraCell Advanced Biotechnology for the Development of Cell and Gene Therapies

Orgenesis Inc. announced that it has entered into a Master Service and Joint Venture Agreement with TheraCell Advanced Biotechnology for the clinical development and commercialization of cell and gene therapies. [Orgensis Inc.] Press Release

FTC Hits Predatory Scientific Publisher with a $50 Million Fine

The Federal Trade Commission (FTC) has won a summary judgement that just might cause some predatory publishers to step back from their business model. An India-based predatory publisher has been hit with a $50 million dollar judgement for deceptive business practices, along with permanent injunctions against most of the activities that made it money. [Ars Technica] Editorial

Bioethicists Concerned over Japan’s Chimera Embryo Regulations

Japanese regulators have effectively given the green light to research involving human-animal chimera embryos. Many researchers see the move to relax the rules as a welcome change, yet some are worried the revisions don’t take public concerns enough into consideration. [The Scientist] Editorial

Risky Stem-Cell Treatments Come Under FDA Scrutiny — Again

The FDA warned rogue stem-cell clinics to stop selling unproven treatments that could harm patients. The agency’s latest effort, like most of its previous ones, consisted only of letters to companies and clinics. [The New York Times] Editorial

NEW Cord Blood Connect
September 13-15, 2019
Miami Beach, Florida, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellows – Hematological Malignancies and Cancer Immunology (Fox Chase Cancer Center)

Postdoctoral Position – Mechanobiology (The University of Texas Health Science Center at Houston)

Postdoctoral Position – Hematopoietic Stem Cells (Washington University School of Medicine)

Postdoctoral Fellow Positions – Human iPS cells, Epigenetics, Hematopoietic Stem Cell Biology, and Blood Cancers (Nationwide Children’s Hospital & Ohio State University)

Tissue Bank Technician – Hematology (University of Oxford)

Laboratory and Clinical Studies Manager – Hematology (University of Oxford)

Assistant Professor – Computational Biology/Stem Cell Biology (University of Illinois at Chicago)

Postdoctoral Scholarship – Proteomics and Erythropoiesis (Lund University)

Faculty Positions – Cancer Research (Shenzhen University)

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