Cord Blood News Volume 11.18 | May 16 2019

TOP STORY

A Collagen Scaffold Loaded with Human Umbilical Cord-Derived Mesenchymal Stem Cells Facilitates Endometrial Regeneration and Restores Fertility

A collagen scaffold (CS) loaded with human umbilical cord-derived mesenchymal stem cells (UC-MSCs) was fabricated and applied for endometrial regeneration. The CS/UC-MSCs promoted human endometrial stromal cell proliferation and inhibited apoptosis in vitro through paracrine effects. [Acta Biomater] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Human Umbilical Cord Mesenchymal Stem Cell Derived Exosomes Encapsulated in Functional Peptide Hydrogels Promote Cardiac Repair

Scientists investigated whether human umbilical cord mesenchymal stem cell derived exosomes encapsulated in functional peptide hydrogels could increase the retention and stability of exosomes and improve heart function in a rat myocardial infarction model. [Biomater Sci] Abstract

Nature vs. Nurture: Defining the Effects of Mesenchymal Stromal Cell Isolation and Culture Conditions on Resiliency to Palmitate Challenge

To determine how the choice of xeno- vs. xeno-free media during isolation and expansion would affect future immunosuppressive function, umbilical cord explants from seven donors were subdivided and cultured within xeno- or xeno-free medias, creating 14 distinct MSC preparations. [Front Immunol] Full Article

Red Blood Cell Transfusion Burden by Day 30 Predicts Mortality in Adults after Single-Unit Cord Blood Transplantation

Researchers retrospectively analyzed the data of 278 adult patients who received single-unit cord blood transplantation in their institute. The median number of red blood cell (RBC) transfusions for each patient was 12 units by day 30 and 14 units by RBC engraftment. [Bone Marrow Transplant] Full Article

Exosomes Secreted by the Cocultures of Normal and Oxygen-Glucose-Deprived Stem Cells Improve Post-Stroke Outcome

Scientists tested the efficacy of therapy with exosomes secreted from human umbilical cord blood-derived MSCs under in vitro hypoxic conditions on post-stroke brain damage and neurological outcome in a rat model of transient focal cerebral ischemia. [Neuromolecular Med] Abstract

Immunophenotypic, Cytotoxic, Proteomic and Genomic Characterization of Human Cord Blood vs. Peripheral Blood CD56^Dim NK Cells

The authors investigated cord blood (CB) vs. peripheral blood (PB) NK cell subset cytotoxicity, function, receptor expression, and genomic and proteomic signatures. The CB CD56^dim compared with PB CD56^dim demonstrated significantly increased expression of NKG2A and NKG2D, respectively. [Innate Immun] Full Article

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Immune Reconstitution following Hematopoietic Stem Cell Transplantation Using Different Stem Cell Sources

Investigators discuss the pattern of immune recovery in the post-transplant period focusing on the impact of stem cell source on immune recovery and HSCT outcome. [Expert Rev Clin Immunol] Abstract

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Predictive Biotech Signs Letter of Intent with IQVIA to Begin Clincial Trial for Osteoarthritis of the Knee

Predictive Technology Group, Inc. announced the signing of a letter of intent with IQVIA to guide the regulatory strategy for its wholly owned subsidiary Predictive Biotech. This collaboration will accelerate the process of identifying and executing the appropriate regulatory pathways for the company’s existing products and future product candidates. [Predictive Technology Group, Inc.] Press Release

ElevateBio Launches to Create and Operate a Portfolio of Highly Innovative Cell and Gene Therapy Companies

ElevateBio announced operations to create and build a broad portfolio of cell and gene therapy companies through partnerships with leading academic researchers, medical centers and entrepreneurs. [ElevateBio (Business Wire, Inc.)] Press Release

Senate Panel Delays Good-Government Bill, Scolds HHS for ‘Moving the Goal Posts’

A Senate panel delayed action on a bipartisan bill to improve government transparency among advisory bodies in deference to concerns from the National Institutes of Health that the legislation would seriously disrupt the agency’s ability to review research proposals. [ScienceInsider] Editorial

To Meet the ‘Plan S’ Open-Access Mandate, Journals Mull Setting Papers Free at Publication

Plan S, the funder-backed scheme to require free online access to scientific literature, aims to shake up the subscription journals that have long dominated scholarly publishing. Now, some publishers are considering an approach they hope will both comply with the plan and maintain their subscription income: allowing authors to post manuscripts in public archives as soon as their papers are published. [ScienceInsider] Editorial

NEW 61^st American Society of Hematology (ASH) Annual Meeting & Exposition
December 7-10, 2019
Orlando, Florida, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Scientist – Hematopoietic Stem Cell Research (DKFZ / HI-STEM)

Postdoctoral Researcher – Normal and Malignant Hematopoiesis (Karolinska Institutet)

Postdoctoral Position – Stem Cell Transplant Immunology (University of Illinois at Chicago)

Research Technician – Leukemia (VIB)

Postdoctoral Researcher – Stem Cells and Erythropoiesis in MDS (Karolinska Institutet)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern)

Assistant, Associate, or Full-Professor Positions – Cancer Research (Brown University)

Postdoctoral Research Fellow – Functional Genomics (Justus Liebig University Giessen)

Postdoctoral Fellows – Hematological Malignancies and Cancer Immunology (Fox Chase Cancer Center)

Postdoctoral Position – Mechanobiology (The University of Texas Health Science Center at Houston)

Postdoctoral Position – Hematopoietic Stem Cells (Washington University School of Medicine)

Faculty Positions – Cancer Research (Shenzhen University)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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