Cord Blood News Volume 11.20 | May 30 2019

TOP STORY

Comparative Evaluation of Morphology and Osteogenic Behavior of Human Wharton’s Jelly Mesenchymal Stem Cells on 2D Culture Plate and 3D Biomimetic Scaffold

Expansion of seeded human Wharton’s jelly mesenchymal stem cells on 2D culture plates and 3D nano‐hydroxyapatite/chitosan/gelatin scaffolds, from morphology and osteoactivity points of view, were investigated. [J Cell Physiol] Abstract

(Ranked by impact factor of the journal)

Umbilical Cord Cell Therapy Improves Spatial Memory in Aging Rats

Investigators assessed the effect of intracerebroventricular administration of human umbilical cord perivascular cells on spatial memory of senile female rats, using intact senile counterparts as controls. [Stem Cell Rev Rep] Abstract

Thrombin Preconditioning Enhances Therapeutic Efficacy of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells in Severe Neonatal Hypoxic Ischemic Encephalopathy

Researchers investigated whether thrombin preconditioning of human Wharton’s jelly-derived MSCs improved paracrine potency and thus the therapeutic efficacy of naïve MSCs against severe hypoxic ischemic encephalopathy. [Int J Mol Sci] Full Article

Safety and Efficacy of Autologous Mononuclear Cell and Stem Cell Apheresis in Very Low‐Weight Children – Experience at a Single Center

The authors present a single‐center experience with 23 procedures in 12 children with weights between 5.2 and 9.5 kg using the Spectra Optia mononuclear cell protocol with blood priming. [J Clin Apher] Abstract

Effect of Intracameral Human Cord Blood-Derived Stem Cells on Lasered Rabbit Trabecular Meshwork

Immediately following diode laser application to trabecular meshwork, human cord blood stem cells were injected intracamerally, in one eye of 12 albino rabbits. [Int Ophthalmol] Abstract

Compliance with Good Manufacturing Practice in the Assessment of Immunomodulation Potential of Clinical Grade Multipotent Mesenchymal Stromal Cells Derived from Wharton’s Jelly

Scientists present a bioprocess design for the production of Wharton’s jelly-derived MSCs and a validated immunopotency assay approved by the competent regulatory authority for batch release together with the study of failure modes in the bioprocess with potential impact on critical quality attributes of the final product. [Cells] Full Article

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Current and Future Perspectives on Allogeneic Transplantation Using Ex Vivo Expansion or Manipulation of Umbilical Cord Blood Cells

In patients with hematologic malignancies, the outcome of umbilical cord blood transplantation has improved and is now comparable to that of matched unrelated donor transplantation. However, the limitation of using umbilical cord blood has been a delay in both hematopoietic and immunologic recovery. [Int J Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Be The Match BioTherapies^® Announces Collaboration with Poseida Therapeutics to Support Development of Life-Saving Cellular Therapies

Be The Match BioTherapies^® announced a collaboration with Poseida Therapeutics to provide end-to-end services to ensure timely collection, transport and delivery of high-quality cellular starting material to meet the specifications and needs of Poseida throughout the development of their autologous CAR-T programs. [Be The Match BioTherapies^®] Press Release

Rexgenero Successfully Expands Manufacturing of REX-001 through Partnership with German Red Cross Blood Donor Service

Rexgenero announced that it has successfully expanded manufacturing of its lead development candidate REX-001 through a partnership with the German Red Cross Blood Donor Service signed earlier this year. [Rexgenero Ltd.] Press Release

Here’s Why the Outcomes of This Week’s European Elections Are Good News for Science

Although populist and euroskeptic parties grew in last week’s elections for the European Parliament, the tsunami that EU supporters feared didn’t happen. That comes as a relief to many scientists, because several of the populist movements now on the rise in Europe appear to have little interest in science, flirt with antiscientific ideas, or have tried to curtail academic freedom. [ScienceInsider] Editorial

White House Sends Mixed Messages on 2020 Research Spending Bills

President Donald Trump doesn’t want Congress to boost the budgets of the National Institutes of Health or the National Science Foundation. But he has no objection to giving more research dollars to parts of the Department of Energy and NASA. [ScienceInsider] Editorial

NEW 7^th Annual German Stem Cell Network Conference
September 23-25, 2019
Berlin, Germany

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Researcher – Acute Myeloid Leukemia (Karolinska Institutet)

NEW Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center)

PhD Student – Hematopoietic Stem Cell Biology/Immunology (Medizinische Fakultät Carl Gustav Carus)

Research Assistant – Lymphoma/Myeloma (MD Anderson Cancer Center)

Postdoctoral Position – Epigenetic Regulation of Hematopoietic Stem Cells (Karolinska Institutet)

Postdoctoral Scientist – Hematopoietic Stem Cell Research (DKFZ / HI-STEM)

Postdoctoral Researcher – Normal and Malignant Hematopoiesis (Karolinska Institutet)

Postdoctoral Position – Stem Cell Transplant Immunology (University of Illinois at Chicago)

Research Technician – Leukemia (VIB)

Faculty Positions – Cancer Research (Shenzhen University)

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