Cord Blood News Volume 11.21 | Jun 6 2019

TOP STORY

Prognostic Index for Patients with Relapsed or Refractory Acute Myeloid Leukemia Who Underwent Hematopoietic Cell Transplantation: A KSGCT Multicenter Analysis

A multicenter retrospective study was performed to explore a prognostic scoring index in order to identify the population least likely to benefit from allogeneic hematopoietic cell transplantation in patients with relapsed or refractory acute myeloid leukemia. [Leukemia] Abstract

(Ranked by impact factor of the journal)

Geometric Sketching Compactly Summarizes the Single-Cell Transcriptomic Landscape

Investigators describe how to enhance and accelerate single-cell data analysis by summarizing the transcriptomic heterogeneity within a dataset using a small subset of cells, which they refer to as a geometric sketch. A sketch of umbilical cord blood cells uncovered a rare subpopulation of inflammatory macrophages, which the authors experimentally validated. [Cell Syst] Abstract | Graphical Abstract

Remission of Inflammatory Bowel Disease in Glucose-6-Phosphatase 3 Deficiency by Allogeneic Hematopoietic Stem Cell Transplantation

Scientists showed that allogeneic hematopoietic stem cell transplantation resolved G6PC3-associated immunodeficiency and the Crohn’s disease phenotype. [J Crohns Colitis] Full Article

Human Mid-Trimester Amniotic Fluid (Stem) Cells Lack Expression of the Pluripotency Marker OCT4A

Researchers performed extensive gene and protein expression analyses to discover that neither frozen, nor fresh human mid-trimester amniotic fluid stem cells cultivated in multipotent stem cell culture conditions expressed OCT4A, and that the OCT4A positive results from the literature are likely to be attributed to the expression of pseudogenes or other OCT4 variants. [Sci Rep] Full Article

Role of Alternative Donor Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Intermediate- or Poor-Risk Acute Myeloid Leukemia in First Complete Remission

Scientists analyzed 1561 patients who underwent hematopoietic stem cell transplantation (HCT) from an HLA-matched related donor, HLA 8/8-matched unrelated donor, or umbilical cord blood (UCB). The results of a multivariate analysis showed that HCT from UCB, age ≥ 50 years, male, PS > 1, and poor-risk cytogenetics had an inferior prognostic impact on overall survival. [Bone Marrow Transplant] Abstract

A Single-Center, Retrospective Review of Robot-Assisted Laparoscopic Prostatectomy with and without Cryopreserved Umbilical Cord Allograft in Improving Continence Recovery

A single-center, retrospective study was performed on 200 patients who underwent bilateral, nerve-sparing robot-assisted radical prostatectomy with and without placement of umbilical cord around the neurovascular bundles. [J Robot Surg] Full Article

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Single Cord Blood Transplantation in Japan; Expanding the Possibilities of CBT

The author compares the most recent outcomes of cord blood transplantation (CBT) with those of other stem cell sources and discusses the potential of CB and several outstanding issues that require resolution. [Int J Hematol] Abstract

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Cellenkos, Inc. Initiates Phase I Clinical Trial of CK0801 for Treatment of Bone Marrow Failure Syndromes

Cellenkos, Inc. announced the initiation of a Phase I Clinical Trial of CK0801, a first-in-class, allogeneic cord blood-derived T-regulatory cell product, for treatment of patients with bone marrow failure syndromes, including aplastic anemia, hypoplastic myelodysplasia, and primary myelofibrosis. [Cellenkos, Inc. (PR Newswire Association LLC.)] Press Release

Bioventus to Co-Develop Next Generation Placental Tissue Product for Knee Osteoarthritis with MTF Biologics

Bioventus has entered into a development collaboration agreement with MTF Biologics to co-develop a next generation placental tissue product for the treatment of painful musculoskeletal conditions, with an initial focus on knee osteoarthritis. [Bioventus] Press Release

Powerful US Senator Calls for Vetting NIH Grantees at Hearing on Foreign Influences

Research typically enjoys bipartisan support in the US Congress. But when it comes to the increasingly contentious topic of academic espionage by foreign governments, politics is never far from the surface. At a hearing of the Senate Committee on Finance, Chairman Chuck Grassley urged federal agencies to do more to thwart “real, aggressive, and ongoing” attempts by foreign entities to steal the fruits of US-funded research. [ScienceInsider] Editorial

Hungarians Protest against Proposed Government Takeover of Science

Thousands of scientists and their supporters marched through the streets of Budapest on 2 June to protest against a proposed law that would give the Hungarian government direct control of the country’s top research institutes. [Nature News] Editorial

NEW Cell & Gene Meeting on the Mesa
October 2-4, 2019
Carlsbad, California, United States

Visit our events page to see a complete list of events in the community.

NEW Assistant Director – Cell Therapy Laboratory (MD Anderson Cancer Center)

NEW Research Associate – Oncology and Hematology (University of Manitoba)

NEW Researcher – Hematological and Cardiovascular Molecular Epidemiology (Uppsala University)

Postdoctoral Researcher – Acute Myeloid Leukemia (Karolinska Institutet)

Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center)

Postdoctoral Position – Epigenetic Regulation of Hematopoietic Stem Cells (Karolinska Institutet)

Postdoctoral Scientist – Hematopoietic Stem Cell Research (DKFZ / HI-STEM)

Postdoctoral Position – Stem Cell Transplant Immunology (University of Illinois at Chicago)

Research Technician – Leukemia (VIB)

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