Cord Blood News 11.23 June 20, 2019 | |
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TOP STORYThe authors tested the potential for overexpression of interleukin-10 (IL-10) in human umbilical cord MSCs to increase MSC efficacy in Escherichia coli pneumosepsis and to enhance human macrophage function. [J Clin Med] Abstract | Download Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers compared the neuroprotection of two forms of human umbilical cord blood-derived MSCs on retinal ganglion cells and axon regeneration after optic nerve crush in vivo, and investigated the molecular mechanism. [Exp Eye Res] Abstract | Graphical Abstract Investigators quantified the plasma markers of peroxidation in patients affected by preeclampsia (PE) and intrauterine growth restriction (IUGR) and examined the role of oxidative stress in the pathophysiology of PE and IUGR in vitro by using human umbilical cord mesenchymal stem cells from physiological and pathological pregnancies and a trophoblast cell line. [PLoS One] Full Article MSCs derived from cord lining membrane were characterized and applied for in vitro toxicity screening of magnetite nanoparticles (Fe3O4NP). Cytotoxicity, internalization/uptake, differentiation and proliferative capacity were evaluated after exposure to different Fe3O4NP concentrations. [J Appl Toxicol] Abstract Researchers investigated effect of common ex vivo expansion method on engraftment potential of human umbilical cord blood-mononuclear cells, using normal fetal mouse, as a model with more similarity to human physiological conditions. [Cell J] Full Article Scientists assessed the MSCs characteristic of human Wharton’s jelly mesenchymal stromal cells in in vitro culture according to the criteria established by the International Society for Cellular Therapy. [Methods Mol Biol] Abstract Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSMesenchymal Stem Cells: Cell Therapy and Regeneration Potential The authors discuss and compare the characteristics of MSCs, and suggest that the variations in their distinctive features are dependent on the source and method of isolation as well as epigenetic changes during maintenance and growth. They also discuss the potential opportunities and challenges of MSC research with the hope to stimulate their use for therapeutic and regenerative medicine. [J Tissue Eng Regen Med] Abstract Transplantation of Stem Cells from Umbilical Cord Blood as Therapy for Type I Diabetes Researchers compare the general characteristics of umbilical cord blood-derived (UCB) multipotent stem cells and UCB-MSCs and introduce their applications in type I diabetes mellitus. [Cell Tissue Res] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSThermoGenesis Corp. announced that it has received Health Canada approval of its next-generation AXP®II system for cord blood processing. [ThermoGenesis Corp.] Press Release Bone Therapeutics announced that its allogeneic cell therapy product, ALLOB, successfully completed the 12 month follow-up period of a Phase IIa study in patients undergoing a lumbar spinal fusion procedure. [Bone Therapeutics S.A.] Press Release | |
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POLICY NEWSTrump Issues Executive Order that Could Reduce Scientific Advice President Donald Trump issued an executive order on June 14 to cut back the number of advisory committees by at least a third by the end of September, according to a statement from the White House. The federal advisory committee system is the formal structure for government agencies to seek advice from experts including scientists. [The Scientist] Editorial China Clamps Down on Foreign Use of Chinese Genetic Material and Data China has announced new regulations for the use of human genetic resources that come from Chinese participants. The rules, announced on June 10, require international scientists using biomaterials from China to have a Chinese collaborator and go into effect on July 1. [The Scientist] Editorial Academics Join Outcry Sparked by Hong Kong’s Contentious Extradition Bill Since the bill that would legalize the extradition of people from Hong Kong to mainland China to stand trial or serve criminal sentences was announced, more than a thousand academics from around the world have signed a petition against the proposed law, saying it would restrict free speech and academic debate as well as eroding personal freedoms. [Nature News] Editorial
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EVENTSNEW The XVIII International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Hematopoietic Stem Cell Niche in Leukemia (Erasmus Medical Center) Postdoctoral Studies – Normal and Aberrant Hematopoiesis (Karolinska Institutet) Postdoctoral Position – Leukemia (University of California, San Francisco) Assistant Director – Cell Therapy Laboratory (MD Anderson Cancer Center) Research Associate – Oncology and Hematology (University of Manitoba) Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center) Postdoctoral Position – Stem Cell Transplant Immunology (University of Illinois at Chicago) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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