Cord Blood News Volume 11.24 | Jun 27 2019

TOP STORY

Banking Mesenchymal Stromal Cells from Umbilical Cord Tissue: Large Sample Size Analysis Reveals Consistency between Donors

The authors characterized cord tissue‐MSCs obtained from multiple donors by analyzing cell surface proteins, differentiation capacity, and proteome profile. [Stem Cells Transl Med] Full Article

(Ranked by impact factor of the journal)

Validation of Monoclonal Anti-PKC Isozyme Antibodies for Flow Cytometry Analyses in Human T Cell Subsets and Expression in Cord Blood T Cells

Investigators validated the specificity of commercially available antibodies marketed for flow cytometry to measure PKCα, βI, βII, δ, ε, η, θ, ζ, ι/λ and μ. [Sci Rep] Full Article

A Retrospective Analysis of Safety and Efficacy of Wharton’s Jelly Stem Cell Administration in Children with Spina Bifida

The authors describe the outcome of therapeutic administration of MSCs obtained from Wharton’s jelly in pediatric patients with spina bifida during a medical therapeutic experiment. [Stem Cell Rev Rep] Abstract

Enhanced Hepatogenic Differentiation of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells by Using Three-Step Protocol

Researchers investigated the effects of sodium butyrate, an epigenetic regulator that directly inhibits histone deacetylase, on hepatic endodermal lineage differentiation of human Wharton’s jelly-derived-MSCs. [Int J Mol Sci] Full Article | Graphical Abstract

Comparative Analysis of Mesenchymal Stromal Cells Derived from Rabbit Bone Marrow and Wharton’s Jelly for Adipose Tissue Engineering

Scientists extracted rabbit MSCs from bone marrow (BMSCs) and umbilical cord Wharton’s jelly (WJ-MSCs). Both BMSCs and WJ-MSCs underwent adipogenic differentiation for two weeks, and then were transferred to non-inductive complete medium. [Connect Tissue Res] Abstract

Extracellular Matrix Derived by Human Umbilical Cord-Deposited Mesenchymal Stem Cells Accelerates Chondrocyte Proliferation and Differentiation Potential In Vitro

Investigators developed a 3D cell culture substrate using decellularized extracellular matrix derived from human umbilical cord-derived mesenchymal stem cells, and evaluated the effects on articular chondrocytes. [Cell Tissue Bank] Abstract

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The Role of Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation: Prevention and Treatment of Graft-versus-Host Disease

The authors performed a systematic review and meta-analysis to estimate the effect of MSC infusion on graft-versus-host disease treatment and prevention. [Stem Cell Res Ther] Full Article

Visit our reviews page to see a complete list of reviews in the cord blood research field.

NantKwest Launches First-in-Class, First-in-Human Phase I Clinical Trial with a Targeted PD-L1 t-haNK Cell Therapy in Patients with Solid Tumors

NantKwest Inc. announced that the company’s PD-L1 t-haNK investigational new drug application has cleared FDA review and the program has now transitioned to a first-in-human clinical trial in patients with locally advanced or metastatic solid cancers. [NantKwest Inc.] Press Release

New York Genome Center Awarded $1.5M Chan Zuckerberg Initiative Grant to Develop Integrative Single-Cell Analysis Toolkit for the Human Cell Atlas Project

Scientists at the New York Genome Center and the Icahn School of Medicine at Mount Sinai have been awarded a $1.5 million collaborative grant over three years from the Chan Zuckerberg Initiative to support the development of a toolkit for integrated multimodal cell profiling. [New York Genome Center] Press Release

NIH Probe of Foreign Ties Has Led to Undisclosed Firings—and Refunds from Institutions

An aggressive effort by the National Institutes of Health (NIH) to enforce rules requiring its grantees to report foreign ties is still gathering steam. But it has already had a major impact on the US biomedical research community. A senior NIH official tells ScienceInsider that universities have fired more scientists—and refunded more grant money—as a result of the effort than has been publicly known. [ScienceInsider] Editorial

Discrimination Drives LGBT+ Scientists to Think About Quitting

Nearly one-third of physical scientists from sexual and gender minorities in the United Kingdom have considered leaving their jobs because of their workplace climate, suggests a survey. And 18% who are lesbian, gay, bisexual, transgender or from other sexual and gender minorities (LGBT+) said they had experienced harassment, bullying or exclusionary behavior in the workplace. [Nature News] Editorial

NEW 7^th International Conference on Stem Cell Engineering 2019
December 11-13, 2019
Barcelona, Spain

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Bone/Stem Cell Biology (University of California, San Francisco)

NEW Research Associate – Stem Cell Medicine (University of Cambridge)

NEW Postdoctoral Research Associate – Development, Regeneration and Cell Fate (Michigan State University)

NEW Tenure-Track Positions – Stem Cell Biology and Regenerative Medicine (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Hematopoietic Stem Cell Niche in Leukemia (Erasmus Medical Center)

Postdoctoral Researcher – Next Generation Cell Therapy Process Engineering (University of British Columbia)

Postdoctoral Studies – Normal and Aberrant Hematopoiesis (Karolinska Institutet)

Postdoctoral Position – Leukemia (University of California, San Francisco)

Research Associate – Oncology and Hematology (University of Manitoba)

Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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