Cord Blood News 11.15 July 4, 2019 | |
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TOP STORYHuman cord blood CD34+ cells expressing CD166 produced significantly higher numbers of colony‐forming units following interaction with immobilized CD166 than their CD166− counterparts. [Stem Cells] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Bone Marrow vs Wharton’s Jelly Mesenchymal Stem Cells in Experimental Sepsis: A Comparative Study Scientists observed that both types of MSCs regulated leukocyte trafficking and reduced organ dysfunction, while only Wharton’s jelly-MSCs were able to improve bacterial clearance and survival. [Stem Cell Res Ther] Full Article Investigators examined the correlation between the development of BK viremia and immune reconstitution in 27 adult recipients of umbilical cord blood transplantation. [Clin Immunol] Abstract Male Obesity Effects on Sperm and Next-Generation Cord Blood DNA Methylation The authors have systematically analyzed the effects of male body mass index on sperm epigenome and its association with next-generation fetal cord blood DNA methylation. [PLoS One] Full Article Researchers comparatively assessed the efficacy of human MSCs derived from bone marrow, umbilical cord blood, human embryonic stem cells, or human-induced pluripotent stem cells in a mouse model of chemically induced acute enterocolitis. [Inflammation] Abstract Nitrogen-doped carbon nanocages enhanced the therapeutic effects of human umbilical cord-MSCs on middle cerebral artery occlusion mice, including reducing infarct volume, improving behavior scores and inhibiting inflammation response. [Neurosci Lett] Abstract Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSThe authors review current preclinical studies on the use of extracellular vesicles derived from human umbilical cord MSCs as a therapeutic approach in treatment of several diseases including neurological, cardiovascular, liver, kidney, and bone diseases as well as the cutaneous wound, inflammatory bowel disease, cancers, infertility, and other disorders. [J Cell Physiol] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSUnum Therapeutics Announces Regulatory Update from Phase I Trial with ACTR087 Unum Therapeutics Inc. announced that the FDA has placed a clinical hold on the Phase I trial evaluating Unum’s ACTR087 in combination with rituximab following lymphodepleting chemotherapy with fludarabine and cyclophosphamide in patients with relapsed/refractory CD20+ B cell non-Hodgkin lymphoma. [Unum Therapeutics Inc. (GlobeNewswire Inc.)] Press Release Humanigen, Inc. announced that it has entered into an exclusive worldwide license with the Mayo Clinic to certain technologies used to create CAR-T cells lacking GM-CSF expression through various gene-editing tools including CRISPR-Cas9. [Humanigen, Inc.] Press Release | |
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POLICY NEWSHungarian Law Wrests Control of Research from Scientific Academy The Hungarian Parliament passed a bill that takes control for funding Hungarian research bodies away from the Hungarian Academy of Sciences and gives it to a government-led committee, Reuters reports. [The Scientist] Editorial Why India Is Striking Back against Predatory Journals According to 2015 estimates, more than 8,000 predatory journals churn out more than 400,000 items a year, and India — which has also seen a spurt in high-quality scientific publications — contributes more than one-third of the articles in predatory publications. Last month, India launched its latest salvo against the ‘pay and publish trash’ culture that sustains predatory journals. [Nature News] Editorial
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EVENTSNEW Perinatal Stem Cell Society Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Positions – Age-Related Changes in Hematopoiesis (University of Milano-Bicocca) Postdoctoral Position – Bone/Stem Cell Biology (University of California, San Francisco) Research Associate – Stem Cell Medicine (University of Cambridge) Postdoctoral Fellow – Hematopoietic Stem Cell Niche in Leukemia (Erasmus Medical Center) Postdoctoral Studies – Normal and Aberrant Hematopoiesis (Karolinska Institutet) Postdoctoral Position – Leukemia (University of California, San Francisco) Research Associate – Oncology and Hematology (University of Manitoba) Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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