Cord Blood News Volume 11.25 | Jul 4 2019

TOP STORY

CD166 Engagement Augments Mouse and Human Hematopoietic Progenitor Function via Activation of Stemness and Cell Cycle Pathways

Human cord blood CD34⁺ cells expressing CD166 produced significantly higher numbers of colony‐forming units following interaction with immobilized CD166 than their CD166⁻ counterparts. [Stem Cells] Abstract

(Ranked by impact factor of the journal)

Bone Marrow vs Wharton’s Jelly Mesenchymal Stem Cells in Experimental Sepsis: A Comparative Study

Scientists observed that both types of MSCs regulated leukocyte trafficking and reduced organ dysfunction, while only Wharton’s jelly-MSCs were able to improve bacterial clearance and survival. [Stem Cell Res Ther] Full Article

Reactivation of BK Virus after Double Umbilical Cord Blood Transplantation in Adults Correlates with Impaired Reconstitution of CD4⁺ and CD8⁺ T Effector Memory Cells and Increase of T Regulatory Cells

Investigators examined the correlation between the development of BK viremia and immune reconstitution in 27 adult recipients of umbilical cord blood transplantation. [Clin Immunol] Abstract

Male Obesity Effects on Sperm and Next-Generation Cord Blood DNA Methylation

The authors have systematically analyzed the effects of male body mass index on sperm epigenome and its association with next-generation fetal cord blood DNA methylation. [PLoS One] Full Article

Therapeutic Effects of Mesenchymal Stem Cells Derived from Bone Marrow, Umbilical Cord Blood, and Pluripotent Stem Cells in a Mouse Model of Chemically Induced Inflammatory Bowel Disease

Researchers comparatively assessed the efficacy of human MSCs derived from bone marrow, umbilical cord blood, human embryonic stem cells, or human-induced pluripotent stem cells in a mouse model of chemically induced acute enterocolitis. [Inflammation] Abstract

Nitrogen-Doped Carbon Nanocages and Human Umbilical Cord Mesenchymal Stem Cells Cooperatively Inhibit Neuroinflammation and Protect against Ischemic Stroke

Nitrogen-doped carbon nanocages enhanced the therapeutic effects of human umbilical cord-MSCs on middle cerebral artery occlusion mice, including reducing infarct volume, improving behavior scores and inhibiting inflammation response. [Neurosci Lett] Abstract

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Human Umbilical Cord Mesenchymal Stem Cell‐Derived Extracellular Vesicles: A Novel Therapeutic Paradigm

The authors review current preclinical studies on the use of extracellular vesicles derived from human umbilical cord MSCs as a therapeutic approach in treatment of several diseases including neurological, cardiovascular, liver, kidney, and bone diseases as well as the cutaneous wound, inflammatory bowel disease, cancers, infertility, and other disorders. [J Cell Physiol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Unum Therapeutics Announces Regulatory Update from Phase I Trial with ACTR087

Unum Therapeutics Inc. announced that the FDA has placed a clinical hold on the Phase I trial evaluating Unum’s ACTR087 in combination with rituximab following lymphodepleting chemotherapy with fludarabine and cyclophosphamide in patients with relapsed/refractory CD20⁺ B cell non-Hodgkin lymphoma. [Unum Therapeutics Inc. (GlobeNewswire Inc.)] Press Release

Humanigen Secures Exclusive Worldwide License to Gene-Editing Technology from Mayo Clinic to Improve CAR-T

Humanigen, Inc. announced that it has entered into an exclusive worldwide license with the Mayo Clinic to certain technologies used to create CAR-T cells lacking GM-CSF expression through various gene-editing tools including CRISPR-Cas9. [Humanigen, Inc.] Press Release

Hungarian Law Wrests Control of Research from Scientific Academy

The Hungarian Parliament passed a bill that takes control for funding Hungarian research bodies away from the Hungarian Academy of Sciences and gives it to a government-led committee, Reuters reports. [The Scientist] Editorial

Why India Is Striking Back against Predatory Journals

According to 2015 estimates, more than 8,000 predatory journals churn out more than 400,000 items a year, and India — which has also seen a spurt in high-quality scientific publications — contributes more than one-third of the articles in predatory publications. Last month, India launched its latest salvo against the ‘pay and publish trash’ culture that sustains predatory journals. [Nature News] Editorial

NEW Perinatal Stem Cell Society Congress
September 12, 2019
Miami, Florida, United States

Visit our events page to see a complete list of events in the community.

NEW PhD Positions – Age-Related Changes in Hematopoiesis (University of Milano-Bicocca)

Postdoctoral Position – Bone/Stem Cell Biology (University of California, San Francisco)

Research Associate – Stem Cell Medicine (University of Cambridge)

Postdoctoral Research Associate – Development, Regeneration and Cell Fate (Michigan State University)

Tenure-Track Positions – Stem Cell Biology and Regenerative Medicine (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Hematopoietic Stem Cell Niche in Leukemia (Erasmus Medical Center)

Postdoctoral Researcher – Next Generation Cell Therapy Process Engineering (University of British Columbia)

Postdoctoral Studies – Normal and Aberrant Hematopoiesis (Karolinska Institutet)

Postdoctoral Position – Leukemia (University of California, San Francisco)

Research Associate – Oncology and Hematology (University of Manitoba)

Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center)

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