Cord Blood News Volume 11.27 | Nov 26 2020

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    2020-11-26


    Cord Blood News by STEMCELL Technologies
    Vol. 11.26 – 26 November, 2020
    TOP STORY

    Therapeutic Efficacy of Umbilical Cord-Derived Stem Cells for Diabetes Mellitus: A Meta-Analysis Study

    The clinical efficacy was evaluated based on glycemic control status and β cell function, as well as the daily insulin requirement in diabetic patients after receiving umbilical cord-derived stem cell-transplantation compared to baseline values.
    [Stem Cell Research & Therapy]

    Full Article

    Getting enough cord blood HSCs for transplantation isn't easy. But she's paving the way. Watch Suzan Imren's webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Microenvironmental Changes Induced by Placenta-Derived Mesenchymal Stem Cells Restore Ovarian Function in Ovariectomized Rats via Activation of the PI3K-FOXO3 Pathway

    Blood and ovary tissue were collected and analyzed after various placenta -derived (PD)-MSC transplantation treatments in an ovariectomized rat model. Changes in the expression of folliculogenesis- and ovary regeneration-related genes induced by PD-MSC treatments were analyzed by qRT-PCR, Western blotting, and histological analysis.
    [Stem Cell Research & Therapy]

    Full Article

    Recovery of Human Embryonic Stem Cells-Derived Neural Progenitors Exposed to Hypoxic-Ischemic-Reperfusion Injury by Indirect Exposure to Wharton’s Jelly Mesenchymal Stem Cells Through Phosphatidyl-inositol-3-Kinase Pathway

    Cellular deregulation was assessed by measuring glutathione levels, basal calcium and intracellular calcium response under KCl stimulation, as well as the key parameters of proliferation, glial progenitor marker expression and migration.
    [Cellular and Molecular Neurobiology]

    Abstract

    Interleukin-8 Receptors CXCR1 and CXCR2 Are Not Expressed by Endothelial Colony-Forming Cells

    CXCR1 and CXCR2 were not detected on several clones of cord blood- endothelial colony-forming cell using different antibodies available, in contrast to well-known positive cells.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    Preclinical Characterization and In Vivo Imaging of 111In-Labeled Mesenchymal Stem Cell-Derived Extracellular Vesicles

    Wharton’s jelly-MSC-extracellylar vesicles (EVs) were isolated using Exo-Prep kit followed by characterization of expressing markers and size. After labeled by 111In-oxine, 111In-EVs were injected into C57BL/6 mice followed by μSPECT/CT imaging. Organs were then taken out for ex vivo biodistribution analysis.
    [Molecular Imaging and Biology]

    Abstract

    MiR-196b-5p Inhibits Proliferation of Wharton’s Jelly Umbilical Cord Stem Cells

    Scientists report that overexpression of miR‐196b‐5p in Wharton’s jelly MSCs (WJCMSCs) suppressed proliferation and arrested the cell cycle in G0/G1 phase, whereas knock‐down of miR‐196b‐5p promotes WJCMSC proliferation and cell cycle progression.
    [Febs Open Bio]

    Abstract

    Request your free copy of the 'Bone Marrow Niches and HSC Fates' Wallchart
    REVIEWS

    Umbilical Cord Blood Cells for the Treatment of Preterm White Matter Injury: Potential Effects and Treatment Options

    Investigators summarize pre-term white matter injury pathogenesis and pathophysiology, and the specific properties of different cell types in umbilical cord blood.
    [Journal of Neuroscience Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    Lonza and Be The Match BioTherapies Partner to Expand Vein-to-Vein Cell and Gene Therapy Supply Chain Network

    Be The Match BioTherapies as a preferred partner to provide consistent access to high-quality, healthy donor tissue and cell and gene therapy supply chain support.
    [Be The Match BioTherapies]

    Press Release
    FEATURED EVENT

    ISSCR 2021 Annual Meeting

    June 23 – June 26, 2021
    Hamburg, Germany

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Damaged Tissue Restoration

    University of Illinois at Chicago College of Medicine – Chicago, Illinois, United States

    Scientist – Blood Cell Development and Disorders

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Research Fellow – Stem Cell Biology & Engineering

    New York Blood Center – New York, New York, United States

    Research Professional – Life Sciences

    Stanford University – Stanford, California, United States

    Lab Supervisor – Forensic Toxicology

    United States Drug Testing Laboratories, Inc. – Des Plaines, Illinois, United States

    > See All Jobs

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