Cord Blood News Volume 11.28 | Jul 25 2019

TOP STORY

Human Cord Blood‐Derived Unrestricted Somatic Stem Cell Infusion Improves Neurobehavioral Outcome in a Rabbit Model of Intraventricular Hemorrhage

Unrestricted somatic stem cells (USSCs) were administered to premature rabbit pups with intraventricular hemorrhage (IVH) and their effects on white matter integrity and neurobehavioral performance were evaluated. USSCs were injected either via intracerebroventricular or via intravenous routes in three days premature rabbit pups, 24 hours after glycerol‐induced IVH. [Stem Cells Transl Med] Full Article

(Ranked by impact factor of the journal)

Genipin and EDC Crosslinking of Extracellular Matrix Hydrogel Derived from Human Umbilical Cord for Neural Tissue Repair

Scientists aimed to improve the stability of the previously described extracellular matrix hydrogel derived from human umbilical cord using genipin and N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC), crosslinking at concentration of 0.5–10 mM. [Sci Rep] Full Article

A Gutsy Move for Cell-Based Regenerative Medicine in Parkinson’s Disease: Targeting the Gut Microbiome to Sequester Inflammation and Neurotoxicity

Investigators examined the effects of an intravenously transplanted combination of human umbilical cord blood (hUCB) and plasma into the 6-hydroxydopamine (6-OHDA) lesioned adult rats. Animals received three separate doses of 4×10⁶ hUCB cells with plasma beginning at seven days after stereotaxic 6-OHDA lesion, then behaviorally and immunohistochemically evaluated over 56 days post-lesion. [Stem Cell Rev] Full Article

Prevention of Transfusion‐Transmitted Cytomegalovirus Infection Using Leukoreduced Blood Components in Patients Receiving Seronegative Umbilical Cord Blood Transplantation

Researchers retrospectively analyzed the incidence of cytomegalovirus (CMV) infection in patients treated with cord blood transplantation who received prestorage leukoreduced, CMV‐unselected blood components between 2007 and 2017 in a single Japanese pediatric center. [Transfusion] Abstract

Characterization of an Umbilical Cord Blood Sourced Product Suitable for Allogeneic Applications

Quality attributes of a uniquely processed umbilical cord blood-allograft were enumerated based on identity, safety, purity and potency. [Regen Med] Full Article

The Effect of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Media Containing Serum on Recovery after Laser Treatment: A Double‐Blinded, Randomized, Split‐Face Controlled Study

The authors evaluated the efficacy and safety of a human cord blood cell–conditioned media containing serum and cream on patients who underwent ablative CO₂ fractional laser treatment. [J Cosmet Dermatol] Abstract

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Management of Aplastic Anemia after Failure of Frontline Immunosuppression

The most commonly used treatments after failure of upfront immunosuppression are hematopoietic stem cell transplantation, a second course of immunosuppression and thrombopoietin mimetics alone or in combination with immunosuppression. [Expert Rev Hematol] Abstract

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Humanigen Secures Exclusive Worldwide License for the Prevention of GvHD through GM-CSF Neutralization from the University of Zurich

The Humanigen license covers various patent applications filed by University of Zurich which complement and broaden Humanigen’s leadership position in the application of granulocyte macrophage-colony stimulating factor (GM-CSF) and expand Humanigen’s development platform to include improving allogeneic hematopoietic stem cell therapy. [Humanigen, Inc.] Press Release

America’s Largest Cord Blood Bank, CBR^®, Upgrading to ThermoGenesis’ AXP^® II System

ThermoGenesis announced that CBR^® has begun the process to transition to ThermoGenesis’ next-generation AXP® II System for the rapid processing of cord blood units. [ThermoGenesis] Press Release

Mexico’s New President Shocks Scientists with Budget Cuts and Disparaging Remarks

A package of harsh austerity measures implemented, has had a deep impact on federally funded laboratories and institutes; it includes a 30% cut to fuel for vehicles and office supplies and a 50% cut to international travel funds and payments to contract workers. Scientists say the cuts are a serious threat to the future of Mexican research. [ScienceInsider] Editorial

What Boris Johnson’s Leadership Could Mean for Science

Boris Johnson has been selected as the United Kingdom’s new prime minister — and is poised to lead the country out of the European Union. At the forefront of many scientists’ minds are questions about how Johnson’s leadership, including his support for a ‘no deal’ Brexit, will affect research. They fear that British science has much to lose from a messy departure from the EU. [Nature News] Editorial

NEW From Stem Cell Biology to New Therapies
November 6-8, 2019
Toronto, Ontario, Canada

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NEW Scientific Communications Coordinator (STEMCELL Technologies Inc.)

NEW Early Stage Researchers – Hematopoiesis (Multiple Locations)

Assistant Director – Cell & Gene Therapy Laboratory (MD Anderson Cancer Center)

Faculty Positions – Cancer and Blood Diseases (The Research Institute at Nationwide Children’s Hospital)

PhD Positions – Age-Related Changes in Hematopoiesis (University of Milano-Bicocca)

Postdoctoral Position – Bone/Stem Cell Biology (University of California, San Francisco)

Research Associate – Stem Cell Medicine (University of Cambridge)

Postdoctoral Research Associate – Development, Regeneration and Cell Fate (Michigan State University)

Tenure-Track Positions – Stem Cell Biology and Regenerative Medicine (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Hematopoietic Stem Cell Niche in Leukemia (Erasmus Medical Center)

Postdoctoral Researcher – Next Generation Cell Therapy Process Engineering (University of British Columbia)

Postdoctoral Studies – Normal and Aberrant Hematopoiesis (Karolinska Institutet)

Postdoctoral Position – Leukemia (University of California, San Francisco)

Research Associate – Oncology and Hematology (University of Manitoba)

Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center)

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