Cord Blood News Volume 11.30 | Aug 8 2019

TOP STORY

Anti-Glycan IgM Repertoires in Newborn Human Cord Blood

While natural antibodies to protein antigens have been studied in depth, little is known about natural antibodies to carbohydrate antigens. To address this, researchers profiled IgM from umbilical cord blood and matched maternal sera on a glycan microarray. [PLoS One] Full Article

(Ranked by impact factor of the journal)

An Open Label Trial of Cryopreserved Human Umbilical Cord in the Treatment of Complex Diabetic Foot Ulcers Complicated by Osteomyelitis

Clinical trials of potential new therapies for diabetic foot ulcers rarely enroll patients whose wounds extend to muscle, fascia, or bone with clinical and radiographic evidence of underlying osteomyelitis. An open label, multicenter trial of cryopreserved human umbilical cord was undertaken in 32 subjects presenting with such complex wounds. [Wound Repair Regen] Abstract

Body Mass Index Does Not Impact Hematopoietic Progenitor Cell Mobilization for Autologous Hematopoietic Cell Transplantation

The authors analyzed the impact of obesity on hematopoietic progenitor cell mobilization as well as key outcomes that are associated with cell dose in autologous hematopoietic cell transplantation recipients. [J Clin Apher] Abstract

Predictive Factors for Successful Peripheral Blood Stem Cell Mobilization and Collection in Children

Factors affecting the success of peripheral blood stem cell collection in children are not well characterized. Investigators reviewed 218 stem cell collections among 199 pediatric donors, of which 35 were from healthy sibling donors and 164 were for autologous collections. [J Clin Apher] Abstract

ER-Stressed MSC Displayed More Effectively Immunomodulation in RA CD4⁺CXCR5⁺ICOS⁺ Follicular Helper-Like T Cells through Higher PGE2 Binding with EP2/EP4

Scientists analyzed the further immunomodulatory effects of endoplasmic reticulum (ER)-stressed umbilical cord-derived MSCs on rheumatoid arthritis (RA) CD4⁺CXCR5⁺ICOS⁺T cells. [Mod Rheumatol] Abstract

Comparison between Adult and Fetal Adnexa Derived Equine Post-Natal Mesenchymal Stem Cells

Researchers describe and compared characteristics, immune properties, and ultrastructural morphology of equine adult and fetal adnexa derived MSCs. [BMC Vet Res] Full Article

Short Term Results of Fibrin Gel Obtained from Cord Blood Units: A Preliminary In Vitro Study

Investigators showed that high volume cord blood units (CBUs) were characterized by greater recovery rates, concentration and number of platelets compared to the low volume CBUs. Proteomic analysis revealed the presence of key proteins for regenerative medicine. Fibrin gel was successfully produced from CBUs of all groups. [Bioengineering] Full Article

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Rapid Review: Next Generation of Cord Blood Banks; Transplantation and Beyond

Use of cord blood for transplantation has decreased in recent years as haplo‐identical stem cell transplants have achieved similar short‐term clinical outcomes. For most patients, however, the optimal stem cell source remains unclear. [Transfusion] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Forty Seven, Inc. Announces $6 Million in Funding from the Leukemia & Lymphoma Society TAP to Accelerate the Development of 5F9 in Myelodysplastic Syndrome

Forty Seven, Inc. announced additional funding commitments from the Leukemia & Lymphoma Society, aimed at accelerating the development of 5F9 for the treatment of myelodysplastic syndromes. [Forty Seven, Inc.] Press Release

Mexican Science Suffers under Debilitating Budget Cuts

Austerity measures recently enacted by Mexico’s president are pushing the country’s scientific efforts — chronically underfunded for years — to a breaking point, according to researchers. [Nature News] Editorial

China Approves Ethics Advisory Group after CRISPR-Babies Scandal

China will establish a national committee to advise the government on research-ethics regulations. The decision comes less than a year after a Chinese scientist sparked an international outcry over claims that he had created the world’s first genome-edited babies. [Nature News] Editorial

NEW 2019 Till & McCulloch Meetings
November 4-6, 2019
Montreal, Quebec, Canada

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Scholar – Gene and Cell Therapy (Stanford University)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Associate Professor – Pediatrics (Pennsylvania State University)

Early Stage Researchers – Hematopoiesis (Multiple Locations)

Faculty Positions – Cancer and Blood Diseases (The Research Institute at Nationwide Children’s Hospital)

PhD Positions – Age-Related Changes in Hematopoiesis (University of Milano-Bicocca)

Postdoctoral Position – Bone/Stem Cell Biology (University of California, San Francisco)

Postdoctoral Research Associate – Development, Regeneration and Cell Fate (Michigan State University)

Tenure-Track Positions – Stem Cell Biology and Regenerative Medicine (Icahn School of Medicine at Mount Sinai)

Postdoctoral Researcher – Next Generation Cell Therapy Process Engineering (University of British Columbia)

Postdoctoral Position – Leukemia (University of California, San Francisco)

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