Cord Blood News Volume 11.30 | Dec 17 2020

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    Justin.choi
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    2020-12-17 | CBN 11.30


    Cord Blood News by STEMCELL Technologies
    Vol. 11.30 – 17 December, 2020
    TOP STORY

    Recombinant
    ACE2 Expression Is Required for SARS-CoV-2 to Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses

    Investigators demonstrated that primary human endothelial cells (ECs) lacked ACE2 receptors at protein and RNA levels and that SARS-CoV-2 was incapable of directly infecting ECs derived from pulmonary, cardiac, brain, umbilical vein, or kidney tissues.
    [mBio]

    Full Article

    Learn about the applications of the CFU assay in toxicity testing from hematopoietic expert Dr. Jackie Damen.
    PUBLICATIONSRanked by the impact factor of the journal

    Matrix
    Stiffness Regulates Myocardial Differentiation of Human Umbilical Cord Mesenchymal Stem Cells

    Human umbilical cord-MSCs were cultured on polyacrylamide hydrogels with stiffnesses corresponding to Young’s modulus of 13-16kPa and 62-68kPa which mimic the stiffnesses of healthy heart tissue and fibrotic myocardium.
    [Aging]

    Full Article

    Allogeneic
    Human Umbilical Cord Wharton’s Jelly Stem Cells Increase Several-Fold the Expansion of Human Cord Blood CD34+ Cells Both In Vitro and In Vivo

    Scientists performed an in-depth evaluation of the primitiveness, migration, adhesion, maturation, mitochondrial behavior, and pathway mechanisms of this platform using conventional assays followed by the evaluation of engraftment potential of the expanded CD34+ cells in an in vivo murine model.
    [Stem Cell Research & Therapy]

    Full Article

    Dual-Enzymatically
    Cross-Linked Gelatin Hydrogel Enhances Neural Differentiation of Human Umbilical Cord Mesenchymal Stem Cells and Functional Recovery in Experimental Murine Spinal Cord Injury

    A dual-enzymatically cross-linked gelatin hydrogel with hydrogen horseradish peroxidase and galactose oxidase was proposed to combine human umbilical cord mesenchymal stem cells for facilitating nerve regeneration post-spinal cord injury.
    [Journal of Materials Chemistry B]

    AbstractPress Release

    Impact
    of HLA Class I Allele-Level Mismatch on Viral Infection within 100 Days after Cord Blood Transplantation

    Overall HLA class I mismatch was also a significant risk factor and the predictor of post-cord blood transplantation viral infection, probably due to the insufficient cytotoxic T cell recognition and dendritic cell priming.
    [Scientific Reports]

    Full Article

    Improving
    the Colonization and Functions of Wharton’s Jelly-Derived Mesenchymal Stem Cells by a Synergetic Combination of Porous Polyurethane Scaffold with an Albumin-Derived Hydrogel

    Wharton’s jelly-derived mesenchymal stem cells were seeded on a polyurethane scaffold combined with a hydrogel based on bovine serum albumin .
    [Biomedical Materials]

    Abstract

    Locally
    Applied Stem Cell Exosome-Scaffold Attenuates Nerve Injury-Induced Pain in Rats

    Researchers developed an alginate scaffold with human umbilical cord mesenchymal stem cell exosomes to treat nerve injury-induced pain. In vitro studies of PC12 and HEK293 cells were used to evaluate the neuroprotective and neurotrophic effects of exosomes.
    [Journal of Pain Research]

    Abstract


    Explore the STEMCELL digital calendar to discover conferences, podcasts, webinars, and more!
    REVIEWS

    The Theoretical Basis of In Utero
    Hematopoietic Stem Cell Transplantation and Its Use in the Treatment of Blood Disorders

    Investigators discuss and evaluate research surrounding key assumptions and the clinical success of in utero stem cell transplantationin the treatment of thalassemia.
    [Stem Cells and Development]

    Abstract
    INDUSTRY AND POLICY NEWS

    Stem Cell Research Finds a Unique Lab- the International Space Station

    Scientists wanted to study how the near-weightless, microgravitational environment of the International Space Station affects building-block cells in the hope of understanding some of the secrets of how they grow, divide and form into tissues.
    [The Washington Post]

    Press Release

    School of Clinical Sciences at Monash Health student Amber Wang tops the 2020 BMedSc(Hons) Cohort

    Monash University congratulates the School of Clinical Sciences student Amber Wang – the highest achieving student in the 2020 BMedSc(Hons) cohort. Wang’s research title was “Effect of Umbilical Cord Blood Cell Therapy on Grey Matter Vascular Injury in the Growth-Restricted Fetal Brain”.
    [Monash University]

    Press Release
    FEATURED EVENT

    ISSCR: Stem Cells and Global Sustainability

    February 3 – 23, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Lead – Cord Blood Bank Collector

    University of Texas MD MD Anderson Cancer Center – Texas, Houston, United States

    Postdoctoral Researcher – MSC Therapeutics

    National University of Ireland Galway – Galway, Ireland

    Senior Research Technologist – Bone Marrow

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Fellow – Damaged Tissue Restoration

    University of Illinois at Chicago College of Medicine – Chicago, Illinois, United States


    Scientist – Blood Cell Development and Disorders

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    > See All Jobs

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