Cord Blood News Volume 11.34 | Sep 5 2019

TOP STORY

Transplantation of Human Umbilical Cord Blood-Derived Cellular Fraction Improves LV Function and Remodeling after Myocardial Ischemia/Reperfusion

Researchers examined whether intramyocardial transplantation of human umbilical cord blood-derived CD45^– Lin^– nonhematopoietic cellular fraction after a reperfused myocardial infarction in nonimmunosuppressed rats would improve cardiac function and ameliorate ventricular remodeling. [Circ Res] Abstract

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Stem Cell Composition of Umbilical Cord Blood following Milking Compared with Delayed Clamping of the Cord Appears Better Suited for Promoting Hematopoiesis

In comparing placental transfusion strategies, blood obtained from an umbilical cord that had been “milked” vs one in which clamping was simply delayed contained mesenchymal stromal cells in addition to solely hematopoietic stem cells, a composition more favorable for hematopoiesis, as suggested by its superior rescue of lethally irradiated bone marrow-depleted mice. [J Pediatr] Abstract

Injury‐Preconditioning Secretome of UCMSCs Amplified the Neurogenesis and Cognitive Recovery after Severe Traumatic Brain Injury in Rats

To simulate the complex microenvironment in the injured brain well, scientists used traumatically injured brain tissue extracts to pretreat umbilical cord mesenchymal stem cells (UCMSCs) in vitro and stereotaxically injected the secretome from traumatic injury‐preconditioned UCMSCs into the dentate gyrus of the hippocampus in a rat severe traumatic brain injury model. [J Neurochem] Abstract

A New Conditioning Regimen Can Significantly Promote Posttransplant Immune Reconstitution and Improve the Outcome of Umbilical Cord Blood Transplantation for Patients

This study included data from 81 consecutively enrolled patients with hematological diseases who had been treated with unrelated umbilical cord blood transplantation between September 2014 and April 2019. [Stem Cells Dev] Abstract

Human Umbilical Cord Blood Monocytes, but not Adult Blood Monocytes, Rescue Brain Cells from Hypoxic-Ischemic Injury: Mechanistic and Therapeutic Implications

The authors found that cord blood mononuclear cells (MNCs) protected neurons from oxygen and glucose deprivation-induced death and reduced both microglial and astrocyte activation. Peripheral blood-MNC failed to affect either outcome. [PLoS One] Full Article

Induction of Regional Chemokine Expression in Response to Human Umbilical Cord Blood Cell Infusion in the Neonatal Mouse Ischemia-Reperfusion Brain Injury Model

Investigators explored the chemokine expression profile in damaged brain tissue in the neonatal mouse ischemia-reperfusion brain injury model that was infused with human umbilical cord blood cells. [PLoS One] Full Article

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Placental Mesenchymal Stromal Cells as an Alternative Tool for Therapeutic Angiogenesis

Placenta-derived MSCs are clinically promising due to their proliferative, migratory, clonogenic and immunomodulatory properties. [Cell Mol Life Sci] Abstract

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Esperite NV and Myrisoph Capital Conclude a Strategic Agreement on Cryo-Save’s Family Stem Cell Banking Business

Esperite NV and Myrisoph Capital Inc announced that they have concluded a strategic agreement related to Cryo-Save’s stem cell cryopreservation business. [Esperite NV] Press Release

Akari Therapeutics’ Nomacopan Granted US Orphan Drug Designation for Hematopoietic Stem Cell Transplantation-Associated Thrombotic Microangiopathy (HSCT-TMA)

Akari Therapeutics, Plc announced that the FDA has granted orphan drug designation for nomacopan for the treatment of HSCT-TMA. [Akari Therapeutics, Plc] Press Release

World Health Organization Backs Open-Access Plan S

The World Health Organization is joining cOAlition S, a growing group of agencies and charities that fund scientific research and that require their grantees to share their work in open-access journals or repositories. [The Scientist] Editorial

New Memo Offers First Glimpse of How Trump’s Science Adviser Would Like to Shape Spending Priorities

A new White House directive laying out next year’s spending priorities for federal research agencies describes a US science enterprise imperiled by internal problems and foreign governments. [ScienceInsider] Editorial

UK Science Minister Jo Johnson Resigns Amid Brexit Drama

UK science minister Jo Johnson has resigned from his position as universities and science minister and as a member of the House of Commons, citing conflicts between what he thinks is best for the country and family ties. [Nature News] Editorial

NEW Cancer Evolution and Combinatorial Cancer Therapies: Concepts and Challenges
January 19-23, 2020
Banff, Alberta, Canada

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NEW Faculty Position – Hematopoietic Biology and Malignancy (The University of Texas MD Anderson Cancer Center)

NEW Postdoctoral Research Associate – Solid Tumors and Leukemia (St. Jude Children’s Research Hospital)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Researcher – Cell Cycles in Stem Cells (University of California, Santa Cruz)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

Postdoctoral Scholarship – Human Erythropoiesis (Lund University)

Postdoctoral Scholarship – Computational Genomics and Bioinformatics (Lund University)

Postdoctoral Scholar – Gene and Cell Therapy (Stanford University)

Associate Professor – Pediatrics (Pennsylvania State University)

Early Stage Researchers – Hematopoiesis (Multiple Locations)

PhD Positions – Age-Related Changes in Hematopoiesis (University of Milano-Bicocca)

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