Cord Blood News Volume 11.36 | Sep 19 2019

TOP STORY

Impact of Homozygous Conserved Extended HLA Haplotype on Single Cord Blood Transplantation: Lessons for Induced Pluripotent Stem Cell Banking and Transplantation in Allogeneic Settings

Researchers analyzed 5017 single cord blood transplantation pairs with HLA-A, B, C, DRB1 allele typing data, and found 39 donor HLA homo donor to patient HLA hetero pairs. [Biol Blood Marrow Transplant] Abstract

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hUC-MSCs Exert a Neuroprotective Effect via Anti-Apoptotic Mechanisms in a Neonatal HIE Rat Model

Scientists investigated how human umbilical cord mesenchymal stem cells exerted a neuroprotective effect via antiapoptotic mechanisms in a neonatal hypoxic-ischemic encephalopathy rat model. [Cell Transplant] Full Article

Transcriptomic and Proteomic Profiling of Human Mesenchymal Stem Cell Derived from Umbilical Cord in the Study of Preterm Birth

Umbilical cord mesenchymal stem cells were collected from ten full-term and eight preterm birth infants for microarray and iTRAQ-based proteome profiling. [Proteomics Clin Appl] Abstract

Bioengineering of Fetal Skin: Differentiation of Amniotic Fluid Stem Cells into Keratinocytes

To obtain human amniotic fluid stem cells, amniotic fluid samples obtained from fetal surgeries were subjected to immunoselection for c-kit. After immunoselection and expansion, most cells were positive for K8, but none for K14. [Fetal Diagn Ther] Abstract

Immunogenicity and Safety of a Quadrivalent Inactivated Influenza Vaccine in Pregnant Women: A Randomized, Observer-Blind Trial

At delivery, hemagglutination inhibition antibody titers for all strains were 1.5-1.9-fold higher in umbilical cord blood than in maternal blood, confirming active transplacental antibody transfer. [Hum Vaccin Immunother] Abstract

The ERK Signaling Pathway Is Involved in Cardiotrophin-1-Induced Neural Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells In Vitro

Researchers investigated the differentiation properties of human umbilical cord blood mesenchymal stem cells transfected with recombinant adenovirus expressing enhanced green fluorescence protein cardiotrophin-1 and the possible mechanisms involved. [Cytotechnology] Abstract

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Human Umbilical Cord Mesenchymal Stem Cells Derived-Exosomes in Diseases Treatment

The authors investigate the applications of human umbilical cord mesenchymal stem cell-derived exosomes in different diseases. [Life Sci] Abstract

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RoosterBio Launches the Only Umbilical Cord hMSC System in the World Designed for Cell Therapy Product Development

RoosterBio, Inc. announced its release of the regenerative medicine industry’s first human umbilical cord mesenchymal stem/stromal cell paired cell and media system designed for product development. [RoosterBio, Inc. (Vocus PRW Holdings, LLC)] Press Release

Testing Chemicals for Birth Defects Using Stem Cells, Not Mice

Researchers at the University of California, Riverside, are part of an ambitious plan at the US Environmental Protection Agency to eliminate animal testing by 2035. Nicole zur Nieden and David Volz received $849,811 to grow human stem cells into bone-like tissue to test industrial and environmental chemicals that might interfere with fetal growth. [University of California, Riverside] Press Release

New Journal Seeks Typically Overlooked Studies

On September 18, Cambridge University Press launched an open-access journal that will address issues in research by taking a different approach to publishing. The journal, Experimental Results, will include findings that have inconclusive or negative results and articles that reproduce or dispute existing research. [The Scientist] Editorial

Senate Bill Would Give NIH $3 Billion in 2020, or 7.7% Boost

A Senate spending panel today released a draft 2020 spending bill containing a hefty $3 billion increase for the National Institutes of Health (NIH) that would bring the agency’s total budget to $42.1 billion. That 7.7% boost is $1 billion more than a House of Representatives committee approved in its version of the bill in April, and would amount to a 40% increase in NIH’s budget over the past five years. [ScienceMagazine] Editorial

NEW Latin American Society for Developmental Biology
October 28-31, 2019
Buenos Aires, Argentina

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NEW Research Associate – Human IPSC Culture (Bayer)

Chair – Inflammation and Hematopoiesis (Technische Universität Dresden)

Tenure-Track Faculty Position – Stem Cell Biology (Albert Einstein College of Medicine)

Faculty Position – Hematopoietic Biology and Malignancy (The University of Texas MD Anderson Cancer Center)

Postdoctoral Research Associate – Solid Tumors and Leukemia (St. Jude Children’s Research Hospital)

Postdoctoral Researcher – Cell Cycles in Stem Cells (University of California, Santa Cruz)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

Postdoctoral Scholarship – Human Erythropoiesis (Lund University)

Postdoctoral Scholarship – Computational Genomics and Bioinformatics (Lund University)

Postdoctoral Scholar – Gene and Cell Therapy (Stanford University)

Associate Professor – Pediatrics (Pennsylvania State University)

PhD Positions – Age-Related Changes in Hematopoiesis (University of Milano-Bicocca)

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