Cord Blood News Volume 11.37 | Sep 26 2019

TOP STORY

Umbilical Cord/Placenta-Derived Mesenchymal Stem Cells Inhibit Fibrogenic Activation in Human Intestinal Myofibroblasts via Inhibition of Myocardin-Related Transcription Factor A

Scientists investigated the anti-fibrogenic properties and mechanisms of MSCs derived from umbilical cord and placenta on human primary intestinal myofibroblasts. [Stem Cell Res Ther] Full Article

(Ranked by impact factor of the journal)

Prospective Phase II Study of Umbilical Cord Blood Transplantation in Adult Acute Leukemia and Myelodysplastic Syndrome

Investigators conducted a prospective Phase II study to assess efficacy and safety of single-unit myeloablative cord blood transplantation in adult leukemia and myelodysplastic syndrome. [Biol Blood Marrow Transplant] Abstract

Therapeutic Effect of Mesenchymal Stem Cells Derived from Human Umbilical Cord in Rabbit Temporomandibular Joint Model of Osteoarthritis

Researchers investigated the potential cartilage-regenerating and anti-inflammatory effects of human umbilical cord matrix-mesenchymal stem cells for the treatment of temporomandibular joint-osteoarthritis. [Sci Rep] Full Article

Proinflammatory Profile of Neonatal Monocytes Induced by Microbial Ligands Is Downmodulated by Histamine

Scientists evaluated the responsiveness of human cord blood cells to Toll-like receptor 4 agonists and the immunomodulatory function of histamine in the inflammatory response. [Sci Rep] Full Article

In Vitro Expansion of Hematopoietic Stem Cells by Inhibition of Both GSK3 and p38 Signaling

When unpurified hematopoietic stem cells (HSCs) were used in culture, inhibition of p38-induced inflammatory cytokine signaling was required to ensure HSC expansion induced by the low concentration of GSK3 inhibitor. [Stem Cells Dev] Abstract

Human Umbilical Cord Perivascular Cells-Derived Extracellular Vesicles Mediate the Transfer of IGF-I to the Liver and Ameliorate Hepatic Fibrogenesis in Mice

The authors evaluated the therapeutic potential of human umbilical cord perivascular cells engineered to produce insulin growth factor like-I (IGF-I) in experimental liver fibrosis and the role of extracellular vesicles in this effect. [Gene Ther] Abstract

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Umbilical Cord-Derived Mesenchymal Stromal Cells in Cardiovascular Disease: Review of Preclinical and Clinical Data

The authors offer an overview of the biological properties of umbilical cord MSCs describing available pre-clinical and clinical data with respect to their potential therapeutic use in cardiovascular regeneration, with current challenges and future directions discussed. [Cytotherapy] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Avalon GloboCare Announces Initiation of First-in-Human Clinical Trial of its CAR-T Candidate, AVA-001, for Treatment of B-Cell Malignancies

Avalon GloboCare Corp. announced it has initiated its first-in-human, Phase I clinical trial of CD19 CAR-T candidate, AVA-001. [Avalon GloboCare Corp.] Press Release

CARsgen Announces Investigational CAR-T Therapy CT053 Granted PRIME Eligibility by the European Medicines Agency

CARsgen Therapeutics Inc. announced the European Medicines Agency has granted PRIority MEdicines (PRIME) eligibility to its investigational CAR-T cell therapy fully human anti-B Cell Maturation Antigen autologous CAR T Cells for the treatment of relapsed or refractory multiple myeloma. [CARsgen Therapeutics Inc. (PR Newswire Association LLC.)] Press Release

How US Sanctions Are Crippling Science in Iran

After almost a year of sanctions put in place by US President Donald Trump, Iran is experiencing economic recession, a depreciating currency and high inflation. All of this is stretching budgets for equipment, supplies and travel, endangering research projects and sapping morale, say researchers. [Nature News] Editorial

The Potent Effects of Japan’s Stem-Cell Policies

A five-year regulatory free-for-all in regenerative medicine has given the industry a boost. But patients might be paying the price. [Nature News] Editorial

NEW Translational Cancer Research for Basic Scientists Workshop
November 17-22, 2019
Boston, Massachusetts, United States

Visit our events page to see a complete list of events in the community.

NEW Visiting Research Specialist – Hematopoietic Stem Cells (University of Illinois)

Research Associate – Human IPSC Culture (Bayer)

Chair – Inflammation and Hematopoiesis (Technische Universität Dresden)

Tenure-Track Faculty Position – Stem Cell Biology (Albert Einstein College of Medicine)

Faculty Position – Hematopoietic Biology and Malignancy (The University of Texas MD Anderson Cancer Center)

Postdoctoral Research Associate – Solid Tumors and Leukemia (St. Jude Children’s Research Hospital)

Postdoctoral Researcher – Cell Cycles in Stem Cells (University of California, Santa Cruz)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

Postdoctoral Scholarship – Computational Genomics and Bioinformatics (Lund University)

Postdoctoral Scholar – Gene and Cell Therapy (Stanford University)

Associate Professor – Pediatrics (Pennsylvania State University)

PhD Positions – Age-Related Changes in Hematopoiesis (University of Milano-Bicocca)

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