Cord Blood News Volume 11.38 | Oct 3 2019

TOP STORY

Human Leukocyte Antigen and Red Blood Cells Impact Umbilical Cord Blood CD34⁺ Cell Viability after Thawing

Investigators found that pre-cryopreservation red blood cells, granulocytes, and viable CD34⁺ cell count significantly impacted CD34⁺ viability after thawing, along with HLA-B or -C. [Int J Mol Sci] Abstract | Download Full Article

(Ranked by impact factor of the journal)

Decorin Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Induces Macrophage Polarization via CD44 to Repair Hyperoxic Lung Injury

To prevent pulmonary inflammation in bronchopulmonary dysplasia, scientists investigated the hypothesis that a key regulator was secreted by MSCs to polarize inflammatory macrophages into anti-inflammatory macrophages at inflammation sites. [Int J Mol Sci] Full Article

Platelet‐Rich Plasma Improves the Therapeutic Efficacy of Mesenchymal Stem Cells by Enhancing Their Secretion of Angiogenic Factors in a Combined Radiation and Wound Injury Model

Researchers investigated the therapeutic effect of combined umbilical cord blood‐derived‐MSCs and platelet‐rich plasma treatment on wound healing in a combined radiation and wound injury mouse model. [Exp Dermatol] Abstract

Leukapheresis Cell Concentration Adjustment Required for a Successful Recovery of HSC after Cryopreservation

Leukapheresis product from thirty patients was cryopreserved in 10% DMSO in cryopreservation bags for their autologous bone marrow transplantation, and 2 ml were cryopreserved in cryovials for post-thaw viability assessment by flow cytometry. The percentage of viable HSCs recovered post-cryopreservation in leukapheresis product was significantly influenced by the concentration of the total nucleated cells cryopreserved per volume. [Cryobiology] Abstract

A Rabbit Model of Osteochondral Regeneration Using Three-Dimensional Printed Polycaprolactone-Hydroxyapatite Scaffolds Coated with Umbilical Cord Blood Mesenchymal Stem Cells and Chondrocytes

The authors investigated a rabbit model of osteochondral regeneration using three-dimensional printed polycaprolactone-hydroxyapatite scaffolds coated with umbilical cord blood mesenchymal stem cells and chondrocytes. [Med Sci Monit] Abstract

Obstetrical and Neonatal Factors Associated with Optimal Public Banking of Umbilical Cord Blood in the Context of Delayed Cord Clamping

Investigators assessed the association of specific newborn and maternal factors with indicators of increased blood-forming capacity in umbilical cord blood to inform strategic collection strategies that could augment the quality of units in public cord blood banks. [Clin Invest Med] Abstract

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Potential Use of Stem Cells for Fertility Preservation

Researchers review the benefits and challenges for three types of stem cell‐based approaches under investigation for male fertility preservation, focusing on the role that promising sources of MSC derived from human umbilical cord, specifically human umbilical cord perivascular cells, could fulfill. [Andrology] Abstract

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Ziopharm Oncology Announces FDA Clearance of IND for Rapid Personalized Manufacture of CD19-Specific CAR-T

Ziopharm Oncology, Inc. announced that the FDA has cleared an investigational new drug application (IND) for a Phase I clinical trial to evaluate CD19-specific CAR-T, produced using a process termed rapid personalized manufacture, as an investigational treatment for patients with relapsed CD19⁺ leukemias and lymphomas. [Ziopharm Oncology, Inc.] Press Release

Yale Scientists Win NIH Awards for Pioneering Work

The Yale School of Medicine’s Valentina Greco and Marina R. Picciotto are among the 11 recipients of the National Institutes of Health’s (NIH) Pioneer Award, which recognizes scientists who have a history of creative research and who show promise in originating ‘pioneering approaches to major challenges.’ Greco and Picciotto will receive $3.5 million dollars of funding over the course of five years. [Yale University] Press Release

Split Decisions: How Brexit Has Taken a Toll on Five Researchers

On 23 June 2016, 34 million U.K. citizens took to the polls to vote on a simple, fateful question: Should the United Kingdom remain a part of the European Union, or should it leave? Nearly 52%—a majority of 1.3 million—wanted out, and conservative politicians vowed to carry out the people’s wishes. [ScienceInsider] Editorial

‘There’s No Taboo, No Bad Ideas’: Anyone Can Help Shape European Union’s New €94 Billion Research Program

These encouraging words were spoken here last week at the European Research and Innovation Days, where policy bigwigs working with the European Commission invited the audience to help shape Europe’s next seven-year research funding program, Horizon Europe, set to begin in 2021. Their message: Anyone can help “cocreate” the program’s outlines. [ScienceInsider] Editorial

Trump Set to Nominate Stephen Hahn as FDA Commissioner, Pending Vetting Process

President Trump is set to nominate Dr. Stephen Hahn to lead the FDA, pending completion of the vetting process, according to two people familiar with the selection process. Hahn, an oncologist, is the chief medical executive at MD Anderson Cancer Center in Houston. [STAT News] Editorial

NEW ISSCR 2020 Stem Cells and Regenerative Medicine
March 13-15, 2020
Shanghai, China

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Normal and Malignant Hematopoiesis (Blood Research Institute)

NEW PhD Positions – Cancer and Developmental Biology (Peter MacCallum Cancer Centre)

NEW Research Fellow – Iron-Altered Hematopoiesis (New York Blood Center)

NEW Postdoctoral Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center)

Research Associate – Human IPSC Culture (Bayer)

Chair – Inflammation and Hematopoiesis (Technische Universität Dresden)

Tenure-Track Faculty Position – Stem Cell Biology (Albert Einstein College of Medicine)

Faculty Position – Hematopoietic Biology and Malignancy (The University of Texas MD Anderson Cancer Center)

Postdoctoral Research Associate – Solid Tumors and Leukemia (St. Jude Children’s Research Hospital)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

PhD Positions – Age-Related Changes in Hematopoiesis (University of Milano-Bicocca)

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