Cord Blood News Volume 11.40 | Oct 17 2019

TOP STORY

Effects of Haplotype Matching on Outcomes after Adult Single Cord Blood Transplantation

Using data from a Japanese registry, investigators analyzed the effect of haplotype matching on outcomes. Patients with hematologic diseases aged 16 years or older who had undergone their first transplantation were included. The effects of haplotype matching and high-frequency HLA haplotype on outcomes were analyzed. [Biol Blood Marrow Transplant] Abstract

(Ranked by impact factor of the journal)

Anti-Inflammatory Effects of Mesenchymal Stem Cell-Derived Exosomal MicroRNA-146a-5p and MicroRNA-548e-5p on Human Trophoblast Cells

The authors investigated whether exosomal miRNAs from amniotic fluid-derived MSCs could regulate the inflammatory response of the human trophoblast cell line HTR8/SVneo. [Mol Hum Reprod] Abstract

A Phase II Study of Reduced Intensity Double Umbilical Cord Blood Transplantation Using Fludarabine, Melphalan, and Low Dose Total Body Irradiation

In this multicenter Phase II single arm study, researchers substituted low dose total body irradiation for antithymocyte globulin in a reduced intensity conditioning regimen with the intent to lower the risk for viral infections after double umbilical cord blood transplantation. [Bone Marrow Transplant] Abstract

Reduced-Dose Plerixafor as a Mobilization Strategy in Autologous Hematopoietic Cell Transplantation: A Proof of Concept Study

The authors demonstrated that the use of reduced doses of plerixafor could be sufficient to collect at least 2 × 10⁶/Kg CD34⁺ peripheral blood stem cell in patients with multiple myeloma or lymphoma undergoing autologous stem cell transplantation. [Transfusion] Abstract

Successful Granulocyte Apheresis Using Medium Molecular Weight Hydroxyethyl Starch

Scientists evaluated the efficiency of granulocyte collection using medium molecular weight high molecular weight hydroxyethyl starch in combination with the Spectra Optia apheresis system. [Int J Hematol] Abstract

Proliferation and Odontogenic Differentiation of Human Umbilical Cord Mesenchymal Stem Cells and Human Dental Pulp Cells Co-Cultured in Hydrogel

Investigators evaluated the proliferation and odontogenic differentiation of human dental pulp cells and human umbilical cord mesenchymal stem cells in three-dimensional co-culture system which was established with the help of bone morphogenetic protein-2 and hydrogel. [Arch Oral Biol] Abstract | Graphical Abstract

Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News.

Umbilical Cord Blood Transplantation and the Impact of the CTLA4 Genotype on Outcomes

The authors present the results of the latest studies investigating the link between CTLA4 gene variability and umbilical cord blood transplantation outcomes. [Expert Rev Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

City of Hope Helps Found Biotechnology Hub for Los Angeles County’s Life Sciences Industry

City of Hope announced that it is a founding sponsor of Bioscience Los Angeles County, a nonprofit aiming to catalyze biotechnology and life sciences innovation in the region. [City of Hope] Press Release

BostonGene Announces Cancer Research Collaboration with Washington University in St. Louis

BostonGene Corporation announced a master agreement with Washington University School of Medicine in St. Louis to collaborate on multiple research projects. [BostonGene Corporation] Press Release

Medicine by Design to Accelerate Regenerative Medicine Discovery and Translation with New $20-Million Investment

Medicine by Design is strengthening the University of Toronto as a global leader in regenerative medicine with a new investment of as much as $20 million in research that will accelerate stem cell and gene therapy, advance understanding of how the body repairs itself, and generate new technologies that will propel the field for decades. [Medicine by Design] Press Release

$3 Billion Ballot Proposition Will Decide Fate of Texas Cancer Research Funding Agency

On 5 November, Texas residents will decide whether to sustain CPRIT, the second largest public source of cancer funding in the United States after the federal government. At stake is its generous support for 123 tenure-track faculty like Francesca Cole, who investigates cancer and DNA repair. [ScienceInsider] Editorial

Indian Government Tightens Rules on Academic Collaboration with China

India is tightening the rules for academic collaborations with its neighbor and main rival, China. Under a new policy, universities and research institutes must seek permission from the ministries of Home Affairs and External Affairs before signing a collaboration agreement or memorandum of understanding with a Chinese institution. [ScienceInsider] Editorial

NEW Advanced Therapies Congress & Expo
March 30-April 1, 2020
London, United Kingdom

Visit our events page to see a complete list of events in the community.

NEW Group Leader – Vascular Biology, Hematopoiesis or Cardiovascular Disease (University of Wurzburg)

Postdoctoral Fellow – Normal and Malignant Hematopoiesis (Versiti Blood Research Institute)

PhD Positions – Cancer and Developmental Biology (Peter MacCallum Cancer Centre)

Research Fellow – Iron-Altered Hematopoiesis (New York Blood Center)

Postdoctoral Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center)

Research Associate – Human iPSC Culture (Bayer)

Chair – Inflammation and Hematopoiesis (Technische Universität Dresden)

Tenure-Track Faculty Position – Stem Cell Biology (Albert Einstein College of Medicine)

Faculty Position – Hematopoietic Biology and Malignancy (The University of Texas MD Anderson Cancer Center)

Postdoctoral Research Associate – Solid Tumors and Leukemia (St. Jude Children’s Research Hospital)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

PhD Positions – Age-Related Changes in Hematopoiesis (University of Milano-Bicocca)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Cord Blood News? Click here to submit!

Comments or suggestions? Submit your feedback here.