Cord Blood News Volume 11.42 | Oct 31 2019

TOP STORY

Prospective Randomized Study Comparing Myeloablative Unrelated Umbilical-Cord Blood Transplant versus HLA-Haploidentical Related Stem Cell Transplant for Adults with Hematologic Malignancies

Scientists compared in a prospective randomized study the outcomes of single-unit umbilical cord blood and unmanipulated haploidentical stem cell transplant with postransplant cyclophosphamide in adults with hematological malignancies. [Biol Blood Marrow Transplant] Abstract

(Ranked by impact factor of the journal)

Letermovir Prophylaxis through Day 100 Post Transplant Is Safe and Effective Compared with Alternative CMV Prophylaxis Strategies following Adult Cord Blood and Haploidentical Cord Blood Transplantation

Researchers compared CMV outcomes of three prophylactic approaches used for CBT and haploidentical cord transplants from December 2009 through 2018: letermovir through day 100 post transplant, “valacyclovir day 100”, and “valacyclovir hospital discharge”. [Bone Marrow Transplant] Abstract

Influence of Alternative Donor Type on Early Survival after Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia Lacking a Sibling Donor

This retrospective multicentre study of a French registry compared overall survival in the 18 months following registration in the absence of an HLA-matched related between four types of donors. Between 2012 and 2016, 1302 patients were transplanted using unrelated donor (MUD), mismatched MUD, umbilical cord blood and haploidentical donors. [Bone Marrow Transplant] Abstract

Dynamic Regulation of miRNA Expression by Functionally Enhanced Placental Mesenchymal Stem Cells Promotes Hepatic Regeneration in a Rat Model with Bile Duct Ligation

Under hypoxic conditions, compared with migrated naïve placenta-derived mesenchymal stem cells (PD-MSCs), migrated PRL-1(+) PD-MSCs showed improved integrin-dependent migration ability through Ras homolog family-targeted miRNA expression. [Int J Mol Sci] Full Article

Comparison of the Cardiomyogenic Potency of Human Amniotic Fluid and Bone Marrow Mesenchymal Stem Cells

5-azacytidine treated amniotic fluid-MSCs and bone marrow-MSCs were evaluated for the expression of GATA-4, Nkx2.5 and ISL-1 transcripts and proteins by quantitative RT-PCR and Western blotting, respectively as well as for the expression of cardiomyogenic differentiation markers cardiac troponin-T, beta myosin heavy chain and alpha sarcomeric actinin by immunocytochemistry. [Int J Stem Cells] Abstract

A Simple, Efficient and Economical Method for Isolating and Culturing Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells

A sequential culture method was developed that uses two types of culture media to optimize the isolation and culture of human umbilical cord blood-derived-MSCs. [Mol Med Rep] Abstract

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Differentiation of Human Mesenchymal Stem Cells towards Neuronal Lineage: Clinical Trials in Nervous System Disorders

The authors focus on the potential of MSCs as a therapeutic tool to treat neurological disorders, summarizing the state of the art of this topic and the most recent clinical studies. [Biomol Ther] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

NurOwn^® Data Safety Monitoring Board Recommends ALS Phase III Clinical Trial Continue

BrainStorm Cell Therapeutics, Inc. announced that the Phase III clinical trial independent Data Safety Monitoring Board has completed the second, pre-specified interim analysis, of safety outcomes for the first 106 patients who received repeat dosing of NurOwn® in the Phase III trial for ALS patients. [BrainStorm Cell Therapeutics, Inc.] Press Release

Florida Tech to Build $18M Health Sciences Research Center

Florida Institute of Technology will break ground in spring 2020 on a 61,000-square-foot Health Sciences Research Center that will help fill the growing demand for jobs in biomedical engineering and science and allow students and faculty to conduct critical research in labs equipped with the latest cutting-edge technologies, from virtual-dissection tables to atomic force microscopes. [Florida Institute of Technology] Press Release

Swiss Authorities Probe Boehringer Ingelheim and Other Companies for Antitrust Practices

A Swiss government agency that last month opened an antitrust investigation into several drug makers and distributors has now disclosed the names of nearly a dozen companies that may have fixed the market for an ingredient used to make a treatment for stomach pain. [STAT News] Editorial

Increase in Academics Leaving the UK Since Brexit Vote

After the 2016 Brexit referendum, in which voters decided to have the UK leave the European Union (EU), the number of academics from EU countries leaving the United Kingdom for other university jobs increased by almost half, according to Times Higher Education. [The Scientist] Editorial

PhD-Turned-Policy Insider Takes Over World’s Largest Science Society

In January 2020, the 46-year-old structural biologist Sudip Parikh will become the new CEO of AAAS (which publishes Science) as the 171-year-old association pursues its mission to advance science and serve society. [ScienceInsider] Editorial

NEW Gene- and Cell-Based Therapies: CRISPR, Stem Cells, and Beyond
March 2-4, 2020
San Francisco, California, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Immune-Targeting of Leukemic Stem Cells (Karolinska Institutet)

Research Assistant – Stem Cells and Engineering (New York Blood Center)

Group Leader – Vascular Biology, Hematopoiesis or Cardiovascular Disease (University of Wurzburg)

Postdoctoral Fellow – Normal and Malignant Hematopoiesis (Versiti Blood Research Institute)

PhD Positions – Cancer and Developmental Biology (Peter MacCallum Cancer Centre)

Research Fellow – Iron-Altered Hematopoiesis (New York Blood Center)

Postdoctoral Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center)

Tenure-Track Faculty Position – Stem Cell Biology (Albert Einstein College of Medicine)

Faculty Position – Hematopoietic Biology and Malignancy (The University of Texas MD Anderson Cancer Center)

Postdoctoral Research Associate – Solid Tumors and Leukemia (St. Jude Children’s Research Hospital)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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