Cord Blood News Volume 11.43 | Nov 7 2019

TOP STORY

Hematopoietic Stem Cell Transplantation Using Single UM171-Expanded Cord Blood: A Single-Arm, Phase I-II Safety and Feasibility Study

Researchers investigated the safety and feasibility of single UM171-expanded cord blood transplantation in patients with hematological malignancies who did not have a suitable HLA-matched donor. [Lancet Haematol] Abstract

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Microwaves from Mobile Phone Induce Reactive Oxygen Species but Not DNA Damage, Preleukemic Fusion Genes and Apoptosis in Hematopoietic Stem/Progenitor Cells

Scientists investigated whether exposure to microwaves emitted by mobile phones could induce various biochemical markers of cellular damage including reactive oxygen species, DNA single and double strand breaks, preleukemic fusion genes, and apoptosis in umbilical cord blood cells including CD34⁺ hematopoietic stem/progenitor cells. [Sci Rep] Full Article

Alterations in IL-6/STAT3 Signaling by Korean Mistletoe Lectin Regulate the Self-Renewal Activity of Placenta-Derived Mesenchymal Stem Cells

Researchers analyzed the effect of Korean mistletoe lectin on the proliferation of MSCs and expression of stemness markers. They also evaluated the usefulness of placenta-derived MSCs as a screening tool. [Nutrients] Abstract | Download Full Article

Cryopreserved Human Umbilical Cord versus Acellular Dermal Matrix Patches for In Utero Fetal Spina Bifida Repair in a Pregnant Rat Model

The authors compared cryopreserved human umbilical cord versus acellular dermal matrix patches for regenerative repair of in utero spina bifida lesions in an animal model. [J Neurosurg] Abstract

Variations in Umbilical Cord Hematopoietic and Mesenchymal Stem Cells with Bronchopulmonary Dysplasia

Investigators tested the hypothesis that umbilical cord blood-derived CD34⁺ hematopoietic stem cells, cord tissue-derived CD90⁺ and CD105⁺ MSCs vary with bronchopulmonary dysplasia. [Front Pediatr] Abstract | Press Release

Overexpression of Anti-Fibrotic Factors Ameliorates Anti-Fibrotic Properties of Wharton’s Jelly Derived Mesenchymal Stem Cells under Oxidative Damage

The authors hypothesized whether the reduction of the anti-fibrosis property in Wharton’s jelly-MSCs from oxidative damage could be recovered by overexpression of the HGF, IGF1, or SHH gene. [Biosci Trends] Abstract

Successful Use of Hematopoietic Stem Cell Transplantation for 2 Pediatric Cases of Glanzmann Thrombasthenia and Review of the Literature

Scientists report 2 patients with Glanzmann thrombasthenia who successfully underwent allogeneic hematopoietic stem cell transplantation from unrelated donors, including one using umbilical cord blood stem cells. [J Pediatr Hematol Oncol] Abstract

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Therapeutic Properties of Mesenchymal Stem Cell on Organ Ischemia-Reperfusion Injury

The author focusses upon the use of some bone marrow stem cells, adipose-derived stem cells and umbilical cord stem cells on preventing or decreasing the injuries due to ischemia-reperfusion. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Takeda and MD Anderson Announce Collaboration to Accelerate the Development of Clinical-Stage, Off-the-Shelf CAR NK-Cell Therapy Platform

The University of Texas MD Anderson Cancer Center and Takeda Pharmaceutical Company Limited announced an exclusive license agreement and research agreement to develop cord blood-derived chimeric antigen receptor-directed natural killer (CAR NK)-cell therapies, ‘armored’ with IL-15, for the treatment of B-cell malignancies and other cancers. [Takeda Pharmaceutical Company Limited] Press Release

Therapeutics Solutions International Reports Augmentation of Rejuvenating Activity of Cord Blood Plasma by Pterostilbene

Therapeutics Solutions International, Inc. announced new data and a patent filing suggesting that pterostilbene, the active ingredient in its commercially available NanoStilbene™ product, augments the ability of cord blood plasma to suppress biological properties associated with aging. [Therapeutics Solutions International, Inc.] Press Release

Report Sketches Vision for UK Research after Brexit

An eagerly awaited external report, commissioned by the government, lays out research priorities and options if those relationships with Europe are severed. It calls for increased spending on R&D nationwide, a new research fellowship program, and larger chunks of money for universities to quickly target research opportunities. [ScienceInsider] Editorial

South Korea Clamps Down on Academics Attending ‘Weak’ Conferences

South Korea’s education ministry wants to stop academics from participating in conferences that it considers “weak” and of little academic value. The ministry announced on 17 October that it will require all universities to adopt measures to vet academics’ travel to overseas conferences so as to “prevent researchers from engaging in poor academic activities”. [Nature News] Editorial

Texas Voters Approve Second Life for State Cancer Funding Agency

On 5 November, Texas voters approved (64% to 36%) a ballot measure to extend the life of its pioneering state cancer research funding agency, CPRIT, by doubling, to $6 billion, the amount of bonds that can be issued to support the agency. [ScienceInsider] Editorial

NEW Advances in Stem Cells and Regenerative Medicine
March 8-11, 2020
Heidelberg, Germany

Visit our events page to see a complete list of events in the community.

NEW Scientist – Hematopoietic Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

NEW Postdoctoral Fellow – Erythropoiesis (Mount Sinai School of Medicine)

NEW PhD Studentships – Molecular and Cell Biology (University of Oxford)

NEW Faculty Position – Stem Cell Biology and Regenerative Medicine (Yale University School of Medicine)

Postdoctoral Position – Immune-Targeting of Leukemic Stem Cells (Karolinska Institutet)

Research Assistant – Stem Cells and Engineering (New York Blood Center)

Group Leader – Vascular Biology, Hematopoiesis or Cardiovascular Disease (University of Wurzburg)

Postdoctoral Fellow – Normal and Malignant Hematopoiesis (Versiti Blood Research Institute)

PhD Positions – Cancer and Developmental Biology (Peter MacCallum Cancer Centre)

Research Fellow – Iron-Altered Hematopoiesis (New York Blood Center)

Tenure-Track Faculty Position – Stem Cell Biology (Albert Einstein College of Medicine)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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