Cord Blood News 11.44 November 14, 2019 | |
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TOP STORYInvestigators determined whether co‐transplantation of human Wharton’s jelly mesenchymal stem cell‐derived osteoblasts (WJMSC‐OBs) and human differentiated endothelial cells enhanced bone regeneration and stimulates angiogenesis, relative to the seeding of WJMSC‐OBs alone. [J Tissue Eng Regen Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Human umbilical cord blood MSC-derived exosomes were administrated into LO2 cells exposed to hypoxia/reoxygenation and mice subjected to ischemia/reperfusion injury. [Cell Cycle] Abstract Treatment of umbilical cord matrix‐derived MSCs with 5‐azacytidine induced their differentiation into putative cardiac cells, as revealed by the expression of cardiac‐specific troponin T (cTnT), smooth muscles actin, myogenin, smoothelin, cardiac α‐actin genes and cTnT, α‐actinin proteins by RT‐PCR and immunocytochemistry respectively. [J Biomed Mater Res A] Abstract Scientists investigated the effects and possible mechanisms of human umbilical cord blood mononuclear cells on renal tubular interstitial fibrosis after cisplatin-induced acute kidney injury. [Biomed Pharmacother] Abstract | Graphical Abstract The authors established a robust protocol for the generation of neonatal dendritic cells (DCs) from cord blood derived CD34+ hematopoietic stem cells. For the expansion of DC precursor cells they used a cytokine cocktail containing Flt-3 L, SCF, TPO, IL-3 and IL-6. [J Immunol Methods] Full Article Researchers evaluated the effects of human adipose tissue-derived MSCs (AD-MSCs) and umbilical cord tissue-derived MSCs (UC-MSCs) in a dextran sulfate sodium (DSS)-induced mouse model. Human AD-MSCs and UC-MSCs were injected intravenously into a seven-day DSS-induced colitis model. [Biores Open Access] Full Article Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSRe‐Entering the Pluripotent State from Blood Lineage: Promises and Pitfalls of Blood Reprogramming The authors review the progress in blood reprogramming from various perspectives, including the starting materials and subsequent reprogramming strategies. They also discuss the downstream applications of blood‐derived induced pluripotent stem cells, highlighting their clinical value in terms of disease modelling and therapeutic development. [FEBS Lett] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSTherapeutics Solutions International, Inc. announced the signing of a Letter of Intent with Beijing Regenesis Biotechnology Co. Ltd., of Beijing China to develop and commercialize the anti-aging properties of cord blood plasma combined with NanoStilbene. [Therapeutics Solutions International, Inc. (PR Newswire Association LLC)] Press Release Kiadis Pharma N.V. announced that it has completed a strategic portfolio review and has decided to change its strategy and focus all resources and investments on the company’s NK-cell therapy platform and product candidates. The company will discontinue development of ATIR101 and stop its ongoing Phase III trial. [Kiadis Pharma N.V.] Press Release | |
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POLICY NEWSItaly to Launch National Agency for Research Just two months after Italy underwent a crisis of government and established an alliance between two leading political parties, the left-of-center Democratic Party and the anti-establishment Five Star Movement, the country has announced plans to start a National Agency for Research to help oversee the distribution of federal funds. [The Scientist] Editorial EPA’s ‘Secret Science’ Plan Is Back, and Critics Say It’s Worse Critics are blasting a revised Trump administration plan to give the US Environmental Protection Agency (EPA) broad power to ignore research results when setting public health rules if officials decide the underlying data are not adequately accessible to the public. [ScienceInsider] Editorial The Mental Health of PhD Researchers Demands Urgent Attention Two years ago, a student responding to Nature’s biennial PhD survey called on universities to provide a quiet room for “crying time” when the pressures caused by graduate study become overwhelming. At that time, 29% of 5,700 respondents listed their mental health as an area of concern – and just under half of those had sought help for anxiety or depression caused by their PhD study. Things seem to be getting worse. [Nature News] Editorial
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EVENTSNEW Hematopoiesis Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Doctoral Student Position – Immunology and Gene Therapy (Karolinska Institutet) Scientist – Hematopoietic Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.) Postdoctoral Fellow – Erythropoiesis (Mount Sinai School of Medicine) PhD Studentships – Molecular and Cell Biology (University of Oxford) Faculty Position – Stem Cell Biology and Regenerative Medicine (Yale University School of Medicine) Postdoctoral Position – Immune-Targeting of Leukemic Stem Cells (Karolinska Institutet) Research Assistant – Stem Cells and Engineering (New York Blood Center) Group Leader – Vascular Biology, Hematopoiesis or Cardiovascular Disease (University of Wurzburg) Postdoctoral Fellow – Normal and Malignant Hematopoiesis (Versiti Blood Research Institute) PhD Positions – Cancer and Developmental Biology (Peter MacCallum Cancer Centre) Research Fellow – Iron-Altered Hematopoiesis (New York Blood Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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