Cord Blood News Volume 11.47 | Dec 5 2019

TOP STORY

Exposure to Blue Light Stimulates the Proangiogenic Capability of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells

Investigators found that 455-nm blue light was effective for promoting proliferation, migration, and tube formation of human umbilical vein endothelial cells co-cultured with MSCs. [Stem Cell Res Ther] Full Article

(Ranked by impact factor of the journal)

Osteogenic Commitment of Wharton’s Jelly Mesenchymal Stromal Cells: Mechanisms and Implications for Bioprocess Development and Clinical Application

Scientists compared the baseline osteogenic potential of MSC from Wharton’s jelly (WJ) and bone marrow cell sources by cytological staining, quantitative real-time PCR and proteomic analysis, and assessed chemical and biological strategies for priming undifferentiated WJ-MSC. [Stem Cell Res Ther] Full Article

MicroRNA-29a Exhibited Pro-Angiogenic and Anti-Fibrotic Features to Intensify Human Umbilical Cord Mesenchymal Stem Cells-Renovated Perfusion Recovery and Preventing against Fibrosis from Skeletal Muscle Ischemic Injury

Engrafted umbilical cord Wharton’s jelly MSCs (uMSCs) also illustrated comparable effect to restore the flow perfusion and augmented vascular endothelial growth factors-A, -B, and -C expression. Notably, the combination of miR29a and the uMSCs treatments revealed the utmost renovation of limbic flow perfusion. [Int J Mol Sci] Full Article

Mesenchymal Stem/Stromal Cells Metabolomic and Bioactive Factors Profiles: A Comparative Analysis on the Umbilical Cord and Dental Pulp Derived Stem/Stromal Cells Secretome

A comparative study on the metabolomic and bioactive molecules/factors content of the secretome of MSCs derived from two expanding sources: the umbilical cord stroma and the dental pulp is presented and discussed. [PLoS One] Full Article

Evaluation of Reference Genes for Quantitative Real-Time PCR in Wharton’s Jelly-Derived Mesenchymal Stem Cells after Lentiviral Transduction and Differentiation

The aim of this study was to select the reference gene for Wharton’s Jelly-derived MSC that were undergoing transduction and differentiation. In this work, the expression of 32 genes was analyzed, of which two, which had the most stable expression level, were selected. [Mol Biol Rep] Abstract

Homogeneity and Heterogeneity of Biological Characteristics in Mesenchymal Stem Cells from Human Umbilical Cords and Exfoliated Deciduous Teeth

The authors investigated the differences of biological characteristics in human umbilical cord MSCs (UCMSCs) and stem cells from human exfoliated deciduous teeth (SHEDs). UCMSCs and SHEDs were identified by flow cytometry. [Biochem Cell Biol] Abstract

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Review of the Small-Molecule Nicotinamide for Ex Vivo Expansion of Umbilical Cord Blood

The authors review the data for existing and developing ex vivo expansion techniques, with a focus on the pre-clinical and clinical data for nicotinamide-mediated cord blood expansion across both malignant and benign hematologic indications. [Exp Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Akari Therapeutics Announces Pivotal Phase III Trial Design of Nomacopan in Pediatric Hematopoietic Stem Cell Transplant-Related Thrombotic Microangiopathy (HSCT-TMA), following FDA Meeting

Akari Therapeutics, Plc announced the design of a pivotal Phase III pediatric trial in HSCT-TMA following a FDA End-of-Phase II meeting. [Akari Therapeutics, Plc] Press Release

Boston Biomedical, Inc. Enters into an Alliance in Oncology Research with Columbia University, Harvard University and The Wistar Institute

Boston Biomedical, Inc. announced that the company has entered into an alliance in oncology research with three world-leading oncology centers of excellence – Columbia University, Harvard University and The Wistar Institute. [Boston Biomedical, Inc.] Press Release

Chinese Universities with Military Ties Classed as ‘Risky’ Collaborators

Forty-three Chinese universities should be considered ‘very high’ or ‘high’ risk collaborators because of their involvement in research for military and defence purposes, according to an Australian think tank. [Nature News] Editorial

Elsevier Progresses in Open-Access Deal Making

The scholarly publisher has announced several new licensing agreements in both Europe and the US, but some major academic groups are still without contracts and access to journals. [The Scientist] Editorial

NEW Understanding Endothelial Cell Diversity: Regulation and Regenerative Potential
June 28-July 3, 2020
Barcelona, Spain

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

NEW Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine)

NEW Professor – Regenerative Medicine (University of Southern Denmark)

Scientist – Hematopoietic Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Head of Laboratory – Cell Therapies (NHS Blood and Transplant)

Research Fellow – Iron-Altered Hematopoiesis (New York Blood Center)

Doctoral Student Position – Immunology and Gene Therapy (Karolinska Institutet)

Postdoctoral Fellow – Erythropoiesis (Mount Sinai School of Medicine)

PhD Studentships – Molecular and Cell Biology (University of Oxford)

Faculty Position – Stem Cell Biology and Regenerative Medicine (Yale University School of Medicine)

Research Assistant – Stem Cells and Engineering (New York Blood Center)

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