Cord Blood News Volume 11.49 | Dec 19 2019

TOP STORY

The Regulatory Functionality of Exosomes Derived from hUMSCs in 3D Culture for Alzheimer’s Disease Therapy

Both 3D graphene scaffold and 2D graphene film were used as the matrix for human umbilical cord MSC (hUMSC) culture, from which supernatants were obtained to isolate exosomes. [Small] Abstract

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Mesenchymal Stem/Stromal Cell Production Compliant with Good Manufacturing Practice: Comparison between Bone Marrow, the Gold Standard Adult Source, and Wharton’s Jelly, an Extraembryonic Source

Scientists evaluated the impact of MSC tissue origin on production. Three productions of MSC from Wharton’s jelly or from bone marrow were performed according to good manufacturing practice. [J Clin Med] Full Article

Identification of Differentially Expressed Genes by Single‐Cell Transcriptional Profiling of Umbilical Cord and Synovial Fluid Mesenchymal Stem Cells

The authors measured the heterogeneity in human umbilical cord-derived MSCs and human synovial fluid-derived MSCs by single‐cell RNA‐sequencing. [J Cell Mol Med] Full Article

When an HLA Identical Donor Is Not Available in Adults with Hematological Neoplasms: Single-Center Comparison of Single-Unit Cord Blood Transplantation and Haploidentical-Related PBSC Transplantation with PTCy Using a Standardized Conditioning Platform (Thiotepa-Busulfan-Fludarabine)

Researchers analyzed the outcomes of 47 patients who received a single umbilical cord blood transplantation and 30 patients who received a haploidentical related hematopoietic stem cell transplantation with post-transplant cyclophosphamide. [Ann Hematol] Abstract

Large-Scale Automated Hollow-Fiber Bioreactor Expansion of Umbilical Cord-Derived Human Mesenchymal Stromal Cells for Neurological Disorders

Investigators established standard operating and scale-up good manufacturing practice protocols of umbilical cord-human MSC isolation, characterization, expansion and comparison of cells’ properties when harvested on T-flasks versus using a large-scale bioreactor system. [Neurochem Res] Abstract

Radiation Responses of Human Mesenchymal Stem Cells Derived from Different Sources

A comparison of the results from cell proliferation, apoptosis, cell cycle, DNA damage, and DNA repair assays consistently showed that MSCs derived from adipose tissue possessed a significantly stronger radiation resistance capacity than MSCs derived from umbilical cord and gingival, which was accompanied by a higher level of phosphorylated signal transducer and activator of transcription 3 expression. [Dose Response] Full Article

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The Role of Allogeneic Stem Cell Transplantation in the Management of Acute Myeloid Leukemia: A Triumph of Hope and Experience

The accumulated experience of allografting in acute myeloid leukemia over the last four decades has provided critical insights into both the contribution of the conditioning regimen and the graft-versus-leukemia effect to the curative potential of the most common form of immunotherapy utilized in standard clinical practice. [Br J Haematol] Abstract

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GBT and Syros Partner to Discover, Develop and Commercialize Novel Therapies for Sickle Cell Disease and Beta Thalassemia

Global Blood Therapeutics, Inc. and Syros Pharmaceuticals, Inc. announced that they have entered into a collaboration to discover, develop and commercialize novel therapies for sickle cell disease and beta thalassemia. [Global Blood Therapeutics, Inc.] Press Release

Pluristem Completes 75% Enrollment in Its Pivotal Phase III CLI Clinical Study

Pluristem Therapeutics Inc. announced that it has enrolled 75% of the 246 patients planned for its Phase III clinical study of PLX-PAD in the treatment of Critical Limb Ischemia (CLI), the most severe form of peripheral artery disease, caused by fatty deposits in leg arteries obstructing blood flow. [Pluristem Therapeutics, Inc.] Press Release

2020 US Spending Bill Restricts Some Animal Research, Pushes for Lab Animal Retirement

Federal research agencies will be under increased pressure to reduce their use of monkeys, dogs, and cats when President Donald Trump signs the final 2020 US spending bill. [ScienceInsider] Editorial

Trump Picks Computer Scientist to Lead National Science Foundation

US President Donald Trump has nominated Sethuraman Panchanathan, a computer scientist researcher and vice-president at Arizona State University in Tempe, to be the next head of the National Science Foundation. [Nature News] Editorial

NEW Tissue Engineering and Regenerative Medicine International Society European Chapter Meeting 2020
May 26-29, 2020
Manchester, United Kingdom

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NEW Research Associate/Program Manager – Blood Cancer (National University of Ireland Galway)

Scientist – Hematopoietic Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Research Fellow – Stem Cell Biology & Engineering (New York Blood Center)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine)

Professor – Regenerative Medicine (University of Southern Denmark)

Research Fellow – Iron-Altered Hematopoiesis (New York Blood Center)

Postdoctoral Fellow – Erythropoiesis (Mount Sinai School of Medicine)

PhD Studentships – Molecular and Cell Biology (University of Oxford)

Faculty Position – Stem Cell Biology and Regenerative Medicine (Yale University School of Medicine)

Research Assistant – Stem Cells and Engineering (New York Blood Center)

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