Cord Blood News Volume 12.00 | Jan 9 2020

TOP STORY

Human Umbilical Cord Wharton’s Jelly-Derived Mesenchymal Stem Cells Labeled with Mn²⁺ and Gd³⁺ Co-Doped CuInS₂-ZnS Nanocrystals for Multimodality Imaging in a Tumor Mice Model

A hassle-free labeling of human umbilical cord Wharton’s Jelly-derived MSCs with Mn²⁺ and Gd³⁺ co-doped CuInS₂-ZnS NCs was demonstrated in two hours without requiring an electroporation process or transfection agents. [ACS Appl Mater Interfaces] Abstract

(Ranked by impact factor of the journal)

CRISPR-Cpf1 Activation of Endogenous BMP4 Gene for Osteogenic Differentiation of Umbilical Cord-Derived Mesenchymal Stem Cells

Scientists demonstrated a safety-enhanced application of a recently discovered CRISPR-Cpf1 for targeted gene activation, without DNA double-strand break, to facilitate osteogenic differentiation of human umbilical cord-derived MSCs. [Mol Ther Methods Clin Dev] Abstract

Neurovascular Effects of Umbilical Cord Blood-Derived Stem Cells in Growth-Restricted Newborn Lambs

Researchers examined whether umbilical cord blood stem cell treatment stabilized the neurovascular unit and reduced brain injury in preterm ventilated fetal growth restriction lambs. [Stem Cell Res Ther] Full Article

Multi-Laboratory Assay for Harmonization of Enumeration of Viable CD34⁺ and CD45⁺ Cells in Frozen Cord Blood Units

Twelve cord blood units were processed for plasma and red cell reduction following standard operating procedures. Cord blood unit aliquots were shipped to eight participating centers under cryogenic conditions for analysis before and after standardization of protocol. [Cytotherapy] Abstract

Cord Blood Stem Cell Derived CD16⁺ NK Cells Eradicated Acute Lymphoblastic Leukemia Cells Using with Anti-CD47 Antibody

Investigators evaluated antibody dependent cell cytotoxicity effect of cord blood stem cell derived CD16⁺ natural killer (NK) cells with using anti CD47 blocking antibody. CD16⁺ NK cells generated efficiently from CD34 positive cord blood cells in vitro using IL-2, IL-15 and IL-21 cytokines, although it was not dose dependent. [Life Sci] Abstract | Graphical Abstract

Effects of Human Umbilical Cord Mesenchymal Stem Cells on Inflammatory Factors and miR-181a in T Lymphocytes from Patients with Systemic Lupus Erythematosus

Scientists explored the effect of umbilical cord MSCs on the modulation of T lymphocytes from system lupus erythematosus patients and the possible mechanism. [Lupus] Abstract

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Recent Advances in Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia

Allogeneic hematopoietic cell transplantation (HCT), with associated graft-versus-leukemia effects, remains the best postremission strategy for patients with intermediate or high-risk acute myeloid leukemia (AML), with a curative potential. The authors highlight recent advances in allogeneic HCT that broadened access, refined prognostication, and improved outcomes of AML patients undergoing this procedure. [Curr Opin Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Gamida Cell Announces Completion of Patient Enrollment in Ongoing Phase III Clinical Study of Omidubicel

Gamida Cell Ltd. announced that in December the company completed patient enrollment in its Phase III study of the company’s lead clinical program, omidubicel, an investigational advanced cell therapy being evaluated as a potential life-saving treatment option for patients with high-risk hematologic malignancies who are in need of a bone marrow transplant. [Gamida Cell Ltd.] Press Release

Acepodia Announces FDA Clearance of IND for Its NK Cell Therapy Drug Candidate ACE1702 to Treat Patients with HER2-Expressing Solid Tumors

Acepodia announced it has received clearance of its Investigational New Drug (IND) application from the FDA to initiate a Phase I clinical study of its natural killer (NK) cell therapy and lead drug candidate ACE1702 in patients with HER2-expressing solid tumors. [Acepodia (GlobeNewswire, Inc.)] Press Release

Government Call for Science ‘Weirdos’ Prompts Caution from Researchers

Researchers have reacted with surprise and caution to a bizarrely worded job advertisement posted by a senior UK government adviser. The notice calls for scientists, mathematicians and “super-talented weirdos” to work for the prime minister and to help make “rapid progress with long-term problems”, and cites several scientific papers. [Nature News] Editorial

UK Group Tackles Reproducibility in Research

Last month, 10 UK universities became part of the UK Reproducibility Network, joining a network that already includes stakeholders such as the Academy of Medical Sciences, Research Libraries UK, the National Institute for Biological Standards and Control, journals including Nature and PLOS, and local networks of researchers. [The Scientist] Editorial

NEW American Society of Gene & Cell Therapy (ASGCT) Annual Meeting
May 14-15, 2020
Boston, Massachusetts, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral and Scientist Position – Developmental Hematopoiesis and Gene Regulation (Icahn School of Medicine at Mount Sinai)

NEW Research Assistant Professor – Hematology, Oncology and Blood & Marrow Transplantation (University of Iowa)

NEW Postdoctoral Fellow – Cancer Immunotherapy/CAR T Cell Development (City of Hope)

NEW Postdoctoral Research Fellow – Stem Cell Computational Biology (Fred Hutchinson Cancer Research Center)

Scientist – Hematopoietic Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Research Fellow – Stem Cell Biology & Engineering (New York Blood Center)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine)

Professor – Regenerative Medicine (University of Southern Denmark)

Postdoctoral Fellow – Erythropoiesis (Mount Sinai School of Medicine)

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