Cord Blood News 12.01 January 16, 2020 | |
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TOP STORYScientists manufactured human umbilical cord perivascular mesenchymal stromal cells (HUCPVCs) to Good Manufacturing Practice standards. HUCPVCs showed a stable phenotype while undergoing rapid ex vivo expansion at passage 2 to passage 4 and produced proregenerative factors, strongly suppressing T cell responses in the resting state and in response to inflammation. [Sci Transl Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors aimed to determine if umbilical cord Wharton’s jelly derived MSCs implanted in sub-tenon space have beneficial effects on visual functions in retinitis pigmentosa patients by reactivating the degenerated photoreceptors in dormant phase. [Stem Cell Res Ther] Full Article Cardiac function related indicators, inflammatory factors and markers of myocardial injury, cardiomyocyte injury, infarct size, and apoptosis were detected in vivo experiments. The gain-and loss-of function was performed to evaluate the effects of human umbilical cord MSC-exo with down/upregulated miR-19a on acute myocardial infarction rats and hypoxic H9C2 cells. [Cell Cycle] Abstract Researchers investigated the therapeutic effects of human amniotic MSCs on paraquat-induced pulmonary fibrosis in rats and investigate the inflammatory mechanisms. [Life Sci] Abstract Investigators developed a standard protocol to ensure UC-MSC microbiological safety and to assess the risk of vertical transmission of common intracellular pathogens from broodmares to paired UC-MSCs. [Biopreserv Biobank] Abstract Researchers established a safe and effective approach to label the human umbilical cord MSCs derived from the Wharton’s Jelly with superparamagnetic iron oxide nanoparticles as a cell tracer. [Anat Rec] Abstract Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSThe authors survey the potential of MSCs for engineering functional blood vessels in comparison with other cell types including bone marrow mononuclear cells, endothelial precursor cells, differentiated adult autologous smooth muscle cells, autologous endothelial cells, embryonic stem cells, and induced pluripotent stem cells. [Cell Tissue Res] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSTacitus Therapeutics has launched in collaboration with the Mount Sinai Health System to develop stem cell therapies initially targeting blood cancers and related clotting disorders. Their first therapy, HSC100, currently is being investigated in a Phase I clinical trial. [Tacitus Therapeutics] Press Release A Lifeline for Premature Born Babies: Funding Announced for New Stem Cell Research RMIT is part a group of researchers from across the globe developing a new therapy that aims to see if stem cells can be used to regenerate the brain damage caused by premature birth. This brain damage is called ‘encephalopathy of prematurity’. [RMIT University] Press Release | |
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POLICY NEWSNIH Extends Reporting Mandate to More Clinical Trials, but Obscures Their Policing Many companies and medical research institutions fail to meet a long-standing legal mandate to disclose clinical trial results in a federal database. For certain trials, however, compliance is impossible to verify. [ScienceInsider] Editorial Florida Cracks Down on Foreign Government Involvement in Research Florida is launching a statewide investigation into US research exploitation after four University of Florida faculty members and six employees of Moffitt Cancer Center in Tampa failed to disclose ties to foreign programs, reports the Tampa Bay Times. [The Scientist] Editorial
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EVENTSNEW 15th Swiss Stem Cell Network Annual Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Fellow – Hematopoietic Diseases (University College London) Scientist – Hematopoietic Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.) Postdoctoral Fellow – Cancer Immunotherapy/CAR T Cell Development (City of Hope) Research Fellow – Stem Cell Biology & Engineering (New York Blood Center) Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine) Postdoctoral Fellow – Erythropoiesis (Mount Sinai School of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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