Cord Blood News Volume 12.04 | Feb 6 2020

TOP STORY

In Vivo Monitoring of Dynamic Interaction between Neutrophil and Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell in Mouse Liver during Sepsis

Researchers investigated how interactions between neutrophils and human umbilical cord blood (hUCB)-MSCs in the livers of septic mice were involved in mitigating sepsis that was mediated by MSCs. They aimed to determine whether hUCB-MSC application could be an appropriate treatment for sepsis. [Stem Cell Res Ther] Full Article

(Ranked by impact factor of the journal)

Protective Properties of Heme Oxygenase-1 Expressed in Umbilical Cord Mesenchymal Stem Cells Help Restore the Ovarian Function of Premature Ovarian Failure Mice through Activating the JNK/Bcl-2 Signal Pathway-Regulated Autophagy and Upregulating the Circulating of CD8⁺CD28⁻ T Cells

In in vitro and in vivo experiments, mice were treated with the presence or absence of heme oxygenase-1 (HO-1)/shHO-1-transfected umbilical cord-derived MSCs, and the administration of SP600125 or anisomycin, the inhibitor or activator of JNK. The viability and apoptosis of granulosa cells at different time points of co-cultivation were assessed in vitro. [Stem Cell Res Ther] Full Article

Repeated Intramuscular Transplantations of hUCB-MSCs Improves Motor Function and Survival in the SOD1 G⁹³A Mice through Activation of AMPK

Investigators used repeated intramuscular transplantation of human umbilical cord blood-derived (hUCB)-MSCs and observed positive effects on muscle atrophy and oxidative stress. [Sci Rep] Full Article

Reduced Dose of MTX for GvHD Prophylaxis Promotes Engraftment and Decreases Non-Relapse Mortality in Umbilical Cord Blood Transplantation

Scientists conducted a retrospective study to evaluate the safety and efficacy of standard-dose methotrexate (MTX) and mini-dose MTX for graft-versus-host disease (GvHD) prophylaxis in patients who underwent single unit cord blood transplantation against hematological malignancies. [Ann Hematol] Abstract

Epigallocatechin-3-Gallate Protects Wharton’s Jelly Derived Mesenchymal Stem Cells against In Vitro Heat Stress

The authors investigated the protective role of epigallocatechin-3-gallate (EGCG) priming of human Wharton’s jelly derived MSCs against heat-induced stress in vitro along with the involved underlying mechanism. EGCG ameliorated heat-induced injuries as demonstrated by significantly improved cell morphology, viability, triggered cell migration and enhanced expression of heat shock proteins. [Eur J Pharmacol] Abstract

Evaluation of the Biofilm Formation of Staphylococcus aureus and Pseudomonas aeruginosa on Human Umbilical Cord CD146⁺ Stem Cells and Stem Cell-Based Decellularized Matrix

Scientists evaluated CD146⁺ stem cells obtained from human umbilical cord and their extracellular matrix proteins on in vitro P. aeruginosa and S. aureus biofilms to understand their possible antimicrobial activity. [Cell Tissue Bank] Abstract

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Normal Hematopoiesis Is a Balancing Act of Self-Renewal and Regeneration

The authors discuss how the hematopoietic system operates in steady state and stress conditions, what strategies are used to maintain functional integrity, and how de-regulation in the balance between self-renewal and regeneration can drive malignant transformation. [Cold Spring Harb Perspect Med] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Avacta and Daewoong Agree Collaboration and License Agreement with AffyXell Therapeutics

Avacta Group plc announced that it has signed a collaboration and license agreement with AffyXell Therapeutics to develop Affimer proteins to be used by AffyXell for the generation of new cell and gene therapies. [Avacta Group plc] Press Release

Children’s Hospital Los Angeles Receives $25 Million for Pediatric Cancer, Vision and Rehabilitation Programs

Children’s Hospital Los Angeles announced that the Margie and Robert E. Petersen Foundation has contributed $25 million to establish an endowment supporting three of the hospital’s signature programs: the Cancer and Blood Disease Institute, the Vision Center and Inpatient Rehabilitation Services. [Children’s Hospital Los Angeles] Press Release

Cash from Cannabis Companies Creates Conflicted Researchers

Imagine that scientists charged with doing research on tobacco’s health implications were funded by tobacco companies. In fact, the tobacco industry used this tactic for decades to cast doubt on the adverse health effects of smoking. But today it would be an outrageous conflict of interest – research on addictive drugs shouldn’t be paid for by people who stand to profit from selling them. Yet this is exactly what is happening with cannabis. [STAT News] Editorial

Chan Zuckerberg Initiative to Fund 30 Patient Groups, Aiming to Build a Model for Tackling Rare Diseases

On January 3^rd, Mark Zuckerberg and his spouse Dr. Priscilla Chan’s philanthropic vehicle announced a set of grants that executives there hope will create a model for tackling any rare disease: financing patient-led groups, and giving them training and resources. [STAT News] Editorial

NEW ISSCR: Advances in Stem Cell Research: From Single Cells to Organs
October 12-14, 2020
Paris, France

Visit our events page to see a complete list of events in the community.

NEW Research Associate – Cell Culture (Rogosin Institute)

NEW Postdoctoral Research Fellow – Regenerative Medicine (University of Edinburgh)

NEW Tenure-Track/Tenured Faculty Positions – Biomedical Science (Southern University of Science and Technology)

Scientist – Hematopoietic Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Fellow Positions – Epigenetics, 3D Bioprinting, Hematopoietic Stem Cell Biology, Bioengineering, and Blood Cancers (Childrens Hospital & Ohio State University)

Research Fellow – Hematopoietic Diseases (University College London)

Assistant or Associate Professor – Hematopoietic Cell Transplant Program (Fred Hutchinson Cancer Research Center)

Senior Research Scientist – Stem Cell Biology and Disease Modeling (Tata Institute for Genetics and Society)

Research Assistant Professor – Hematology, Oncology and Blood & Marrow Transplantation (University of Iowa)

Postdoctoral Fellow – Cancer Immunotherapy/CAR T Cell Development (City of Hope)

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