Cord Blood News Volume 12.16 | Apr 30 2020

TOP STORY

Engineered Niches Support the Development of Human Dendritic Cells in Humanized Mice

Engraftment of engineered MSCs together with CD34⁺ hematopoietic stem and progenitor cells created an in vivo synthetic niche in the dermis of immunodeficient mice driving the differentiation of classical dendritic cells (DCs) and CD123⁺AXL⁺CD327⁺ pre/AS-DCs. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Exosomes Derived from Mesenchymal Stem Cells Repair a Parkinson’s Disease Model by Inducing Autophagy

The authors demonstrated that human umbilical cord MSC-derived exosomes had a treatment capability for Parkinson’s disease and could traverse the blood-brain barrier. [Cell Death Dis] Full Article

Human Umbilical Cord-Derived Mesenchymal Stem Cells Alleviate Schizophrenia-Relevant Behaviors in Amphetamine-Sensitized Mice by Inhibiting Neuroinflammation

Human umbilical cord-derived MSCs (hUC-MSCs) inhibited schizophrenia-relevant and the neuroinflammatory changes. The main mechanism of hUC-MSCs was associated with the induction of T_regs and production of the anti-inflammatory cytokine, IL-10, in periphery. [Transl Psychiatry] Full Article

The Downregulated Membrane Expression of CD18 in CD34⁺ Cells Defines a Primitive Population of Human Hematopoietic Stem Cells

Scientists analyzed the expression of CD18 in different subsets of human hematopoietic stem and progenitor cells from cord blood, bone marrow, and mobilized peripheral blood samples. [Stem Cell Res Ther] Full Article

Linc02349 Promotes Osteogenesis of Human Umbilical Cord-Derived Stem Cells by Acting as a Competing Endogenous RNA for miR-25-3p and miR-33b-5p

Linc02349 acted as a molecular sponge for miR-25-3p and miR-33b-5p to control expression abundance of SMAD5 and Wnt10b, respectively, which eventually activated Dlx5/OSX pathway and hence promoted osteogenic differentiation. [Cell Prolif] Full Article

Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Renal Ischemia-Reperfusion Injury via Delivery of miR-21

Microvesicles derived from human umbilical cord MSCs inhibited low oxygen-induced human tubule epithelial (HK-2) cell apoptosis through transferring miR-21 to HK-2 cells. Mechanistically, miR-21 directly targeted and negatively regulated programmed cell death protein 4 in HK-2 cells. [Cell Cycle] Abstract

IL-11 and Soluble VCAM-1 Are Important Components of Hypoxia Conditioned Media and Crucial for Mesenchymal Stromal Cells Attraction

Researchers investigated the role of umbilical cord MSC-derived hypoxia-treated bone marrow stromal cells components, namely stromal cell-derived factor 1, interleukin 11 (IL-11) and soluble vascular cell adhesion molecule 1 (sVCAM-1). [Stem Cell Res] Full Article

Purification and Functional Characterization of CD34-Expressing Cell Subsets following Ex Vivo Expansion of Umbilical Cord Blood-Derived Endothelial Colony Forming Cells

Scientists employed fluorescent-activated cell sorting purification to segregate umbilical cord blood derived endothelial colony forming cells using conserved pro-vascular progenitor cell markers CD34 or aldehyde dehydrogenase activity. [Stem Cells Dev] Abstract

miR-153-3p Induces Immune Dysregulation by Inhibiting PELI1 Expression in Umbilical Cord-Derived Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus

Overexpression of miR-153-3p decreased umbilical cord-derived MSCs (UC-MSCs) proliferation and migration, and weakened UC-MSCs-mediated decrease of follicular T helper cells and increase of regulatory T cells through repressing PELI1 in vitro. [Autoimmunity] Abstract

Antioxidant Pretreatment Enhances Umbilical Cord Derived Stem Cells Survival in Response to Thermal Stress In Vitro

Wharton Jelly derived MSCs (WJMSCs) were cultured and pretreated with various doses of antioxidants; vitamin C, vitamin E, vitamin D3 and their cocktail, followed by exposure to in vitro heat injury. Assessment of WJMSCs survival, paracrine release, in vitro wound healing and expression of angiogenic and survival markers was conducted. [Regen Med] Abstract

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Therapeutic Options for Steroid-Refractory Acute and Chronic GVHD: An Evolving Landscape

Scientists summarize the current treatment landscape of steroid-refractory acute and chronic graft versus host disease (GvHD). [Expert Rev Hematol] Abstract

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Rafael Pharmaceuticals Receives Approvals to Open Trial Sites in India and Canada for Pivotal Phase III Trial (ARMADA 2000) of CPI-613^® (Devimistat) in Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML)

Rafael Pharmaceuticals, Inc. announced that the Central Drugs Standard Control Organization granted approval for the opening of sites in India for the company’s Phase III clinical trial in the treatment of AML. [Rafael Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] Press Release

CHMP Grants Positive Opinion for DARZALEX^® (Daratumumab) Subcutaneous Formulation for the Treatment of Patients with Multiple Myeloma

The Janssen Pharmaceutical Companies of Johnson & Johnson announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has issued a Positive Opinion recommending approval for DARZALEX^® subcutaneous formulation for the treatment of adult patients with multiple myeloma in frontline and relapsed/refractory settings. [The Janssen Pharmaceutical Companies of Johnson & Johnson (Business Wire, Inc.)] Press Release

As COVID-19 Forces Conferences Online, Scientists Discover Upsides of Virtual Format

As the novel coronavirus outbreak shutters businesses and disrupts everyday life for billions around the globe, massive annual conferences and small society meetings alike have moved online. The new format poses numerous technical and organizational challenges, but it also offers opportunities- for reaching wider audiences, reducing the carbon footprint of meeting travel, and improving diversity and equity. [ScienceInsider] Editorial

The Pandemic’s Effects on Recruiting International STEM Trainees

Pandemic-related concerns that have arisen for science trainees—shuttered labs, research and education delays, anxiety—are applicable across the board. But international graduate students and postdocs face a suite of unique challenges that raise uncertainty about recruiting and supporting this critical group of researchers in the future. [The Scientist] Editorial

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