Cord Blood News Volume 12.19 | May 21 2020

TOP STORY

Cas9-AAV6-Engineered Human Mesenchymal Stromal Cells Improved Cutaneous Wound Healing in Diabetic Mice

Investigators describe an optimized Cas9-AAV6-based genome editing tool platform for site-specific mutagenesis and integration of up to more than three kilobases of exogenous DNA in the genome of human MSCs derived from the bone marrow, adipose tissue, and umbilical cord blood without altering their ex vivo characteristics. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Modification of PLGA Scaffold by MSC‐Derived Extracellular Matrix Combats Macrophage Inflammation to Initiate Bone Regeneration via TGF‐β ‐Induced Protein

3D-printed poly(lactide-co -glycolide) (PLGA) scaffolds modified with human umbilical cord MSC-derived extracellular matrix (PLGA-ECM) were prepared by a facile tissue engineering technique with physical decellularization and 2.44 ± 0.29 mg cm⁻³ proteins immobilized on the PLGA-ECM contain multiple soluble cytokines with a sustainable release profile. [Adv Healthc Mater] Abstract

Comparative Separation Methods and Biological Characteristics of Human Placental and Umbilical Cord Mesenchymal Stem Cells in Serum-Free Culture Conditions

Investigators selected placentas from 35 informed donors and exploited three commonly used methods. MSCs were isolated from different parts of placental tissue including umbilical cord, amniotic membrane, chorionic membrane, chorionic villi, and deciduae. [Stem Cell Res Ther] Full Article

Tetramethylpyrazine Enhanced the Therapeutic Effects of Human Umbilical Cord Mesenchymal Stem Cells in Experimental Autoimmune Encephalomyelitis Mice through Nrf2/HO-1 Signaling Pathway

The authors evaluated the effects and mechanism of tetramethylpyrazine (TMP) on H₂O₂-stimulated human umbilical cord MSCs (hUCMSCs) and then further investigated the therapeutic effects of TMP-stimulated hUCMSCs on experimental autoimmune encephalomyelitis mice. [Stem Cell Res Ther] Full Article

Exosomes Derived from Umbilical Cord Mesenchymal Stem Cells Alleviate Viral Myocarditis through Activating AMPK/mTOR-Mediated Autophagy Flux Pathway

The effects of human umbilical cord MSC-derived exosomes on myocardial pathology injury, proinflammatory cytokines and cardiac function were evaluated through haematoxylin and eosin staining, quantitative polymerase chain reaction and Doppler echocardiography. [J Cell Mol Med] Full Article

Community Acquired Respiratory Virus Infections in Adult Patients Undergoing Umbilical Cord Blood Transplantation

Scientists retrospectively analyzed community-acquired respiratory virus infections in 216 single-unit myeloablative umbilical cord blood transplantation recipients. [Bone Marrow Transplant] Full Article

Comparison of Reduced-Intensity/Toxicity Conditioning Regimens for Umbilical Cord Blood Transplantation for Lymphoid Malignancies

To investigate which reduced-intensity conditioning (RIC)/reduced-toxicity conditioning (RTC) was superior for umbilical cord blood transplantation for lymphoid malignancies, researchers retrospectively compared three widely used RIC/RTC regimens. [Bone Marrow Transplant] Abstract

Small Molecule 2′-Deoxycytidine Differentiates Human Umbilical Cord-Derived MSCs into Cardiac Progenitors In Vitro and Their In Vivo Xeno-Transplantation Improves Cardiac Function

Hearts transplanted with 2′-deoxycytidine-treated umbilical cord (UC)-MSCs significantly improved the cardiac systolic and diastolic functions and pumping ability as compared to normal UC-MSCs and myocardial infarction groups. [Mol Cell Biochem] Abstract

Effects of Recombinant AavLEA1 Protein on Human Umbilical Cord Matrix Mesenchymal Stem Cells Survival During Cryopreservation

Researchers purified the recombinant AavLEA1 proteins, examined their thermal solubility and the effect of AavLEA1 proteins on the osmotic stress of cells, and studied the effects of the AavLEA1 protein on cryopreservation of human umbilical cord matrix MSCs. [Biopreserv Biobank] Abstract

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Mechanistic Basis of Ex Vivo Umbilical Cord Blood Stem Progenitor Cell Expansion

Scientists address the methods that promote ex vivo cord blood expansion within the context of symmetrical and asymmetrical hematopoietic stem cell division and those that rely on epigenetic mechanisms, along with the reportedly most successful cytokine combinations. [Stem Cell Rev Rep] Abstract

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FDA Approves COVID-19 Trial after Successful Emergency Use of Umbilical Stem Cells from RESTEM

RESTEM announced it has received approval from the FDA for a 60-patient Phase I/IIa study using umbilical cord MSCs to treat patients with severe cases of COVID-19. [RESTEM (PR Newswire Association LLC.)] Press Release

Will Trump White House Tear Down Journal Paywalls? Many Anxiously Await a Decision

Scientific publishers, universities, librarians, and open-access advocates are waiting anxiously to see whether the Trump administration will end a long-standing policy and require that every scholarly article produced with US funding be made immediately free to all. [ScienceInsider] Editorial

Are Women Publishing Less during the Pandemic? Here’s What the Data Say

Early analyses suggest that female academics are posting fewer preprints and starting fewer research projects than their male peers. [Nature News] Editorial

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NEW Postdoctoral Fellow – Cell Biology (Tulane University School of Medicine)

Postdoctoral Fellow – Molecular Hematology (Heidelberg University Hospital)

Head – Hematological Cancer (Ichnos)

Deputy Director – Division of Blood Diseases and Resources (NIH National Heart, Lung, and Blood Institute)

Postdoctoral Position – Tumor Immunology (University of Maryland)

Senior Scientist – Cell Engineering (Merck & Co., Inc.)

Project Manager – Precision Medicine (Prinses Máxima Centrum)

Postdoctoral Researcher – Leukemia (Josep Carreras Leukaemia Research Institute)

Director – Blood Research Institute (Versiti)

Postdoctoral Positions – Leukemia (Temple University School of Medicine)

Faculty Position – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

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