Cord Blood News Volume 12.21 | Jun 4 2020

TOP STORY

Human Umbilical Cord Mesenchymal Stem Cells Attenuate Abdominal Aortic Aneurysm Progression in Sprague Dawley Rats: Implication of Vascular Smooth Muscle Cell Phenotypic Modulation

Scientists demonstrated that the intravenous injection of umbilical cord-MSC attenuated elastase induced aneurysmal expansion, reduced elastin degradation and fragmentation, inhibited MMPs and TNF-α expression, preserved and/or restored vascular smooth muscle cell contractile phenotype in abdominal aortic aneurysm. [Stem Cells Dev] Abstract

(Ranked by impact factor of the journal)

Effects of Cryopreservation and Long-Term Culture on Biological Characteristics and Proteomic Profiles of Human Umbilical Cord-Derived Mesenchymal Stem Cells

Biological characteristics and proteomic profiles of human umbilical cord-derived-MSCs after cryopreserving and long-term culturing were investigated. [Clin Proteomics] Full Article

A Novel Method to Evaluate Prethawing Viability of Cryopreserved CD34⁺ Hematopoietic Stem Cells for Autologous Transplantation

Scientists assessed a novel method to measure postfreezing CD34⁺ cell viability, based on small bag (minibag) samples; results were compared with those obtained on the corresponding mother bags and bag tails. [Transfusion] Abstract

The Activation of NLRP3 Inflammasome Potentiates the Immunomodulatory Abilities of Mesenchymal Stem Cells in Murine Colitis Model

The authors investigated the expression and functional regulation of NLR family pyrin domain containing 3 (NLRP3) inflammasome in human umbilical cord blood-derived MSCs. [BMB Rep] Full Article

The Effects of Umbilical Cord-Derived Macrophage Exosomes Loaded with Cisplatin on the Growth and Drug Resistance of Ovarian Cancer Cells

Researchers developed and compared different methods of loading exosomes released by mononuclear M1 and M2 macrophages from umbilical cord blood with cisplatin. [Drug Dev Ind Pharm] Abstract

Scalable Manufacturing of Human Hematopoietic Stem/Progenitor Cells Exploiting a Co-Culture Platform with Mesenchymal Stromal Cells

Investigators describe a scalable serum-free co-culture system for the expansion of umbilical cord blood-derived CD34⁺-enriched cells using microcarrier-immobilized human bone marrow-derived mesenchymal stromal cells as feeder cells. [Methods Mol Biol] Abstract

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Umbilical Cord-Derived Mesenchymal Stem Cells in Neurodegenerative Disorders: From Literature to Clinical Practice

The authors focus on the preclinical and clinical use of mesenchymal stem cells derived from human umbilical cord in the treatment of neurodegenerative disorders. [Regen Med] Abstract

Progress in the Treatment of Osteoarthritis with Umbilical Cord Stem Cells

Scientists review the biological characterization of Wharton’s jelly-MSCs in recent years, their advantages compared with other stem cells, and their application in the treatment of osteoarthritis in animal experiments and clinical trials. [Hum Cell] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Cellenkos^® Inc. Announces FDA Clearance to Initiate Phase I Double- Blinded, Randomized, Placebo-Controlled Trial of Cryopreserved Cord Blood-Derived T-Regulatory Cells (CK0802) for Treatment of COVID-19 Associated Acute Respiratory Distress Syndrome

Cellenkos Inc. announced that the FDA has cleared the way to initiate a Phase I clinical trial of CK0802 for treatment of COVID-19 associated acute respiratory distress syndrome. [Cellenkos Inc. (PR Newswire Association LLC.)] Press Release

NIH Grapples with Rush to Claim Billions in Pandemic Research Funds

For the second time in just over ten years, the National Institutes of Health (NIH) is scrambling to hand out billions of dollars in emergency research funding and scientists are rushing to get a piece of the action—even as some confusion and concerns abound. [ScienceInsider] Editorial

As the Pandemic Hits Campus Finances, Faculty Face Layoffs

The pandemic has bored holes in budgets at universities and colleges across the US and beyond. To stem the spread of the coronavirus, higher education institutions shuttered their campuses, sent students home, and moved classes online. [The Scientist] Editorial

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NEW Postdoctoral Researcher – Regenerative Medicine (National University of Ireland Galway)

NEW Research Assistant – Regenerative Medicine (National University of Ireland Galway)

Professor – Hematology-Oncology (Karolinska Institutet)

Postdoctoral Fellow – Cell Biology (Tulane University School of Medicine)

Postdoctoral Fellow – Molecular Hematology (Heidelberg University Hospital)

Department Head – Hematological Cancer (Ichnos)

Deputy Director – Division of Blood Diseases and Resources (NIH National Heart, Lung, and Blood Institute)

Postdoctoral Position – Tumor Immunology (University of Maryland)

Senior Scientist – Cell Engineering (Merck & Co., Inc.)

Postdoctoral Researcher – Leukemia (Josep Carreras Leukaemia Research Institute)

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