Cord Blood News Volume 12.22 | Jun 11 2020

TOP STORY

Putative Regulators for the Continuum of Erythroid Differentiation Revealed by Single-Cell Transcriptome of Human BM and UCB Cells

Using single-cell RNA sequencing of primary human terminal erythroid cells isolated directly from adult bone marrow (BM) and umbilical cord blood (UCB), researchers documented the transcriptome of terminally differentiated human erythroblasts at unprecedented resolution. [Proc Natl Acad Sci USA] Abstract

(Ranked by impact factor of the journal)

Human Decidua Basalis Mesenchymal Stem/Stromal Cells Reverse the Damaging Effects of High Level of Glucose on Endothelial Cells In Vitro

The authors investigated the ability of decidua basalis tissue of human term placenta (DBMSCs) to reverse the damaging effects of high levels of glucose on endothelial cells. DBMSCs and endothelial cells were isolated from human placental and umbilical cord tissues, respectively. [J Cell Mol Med] Full Article

Cord Blood Transplants Supported by Unrelated Donor CD34⁺ Progenitor Cells

Investigators report 26 patients who underwent haplo-cord transplant using CD34⁺-selected partially matched unrelated donor grafts. 24 were conditioned with fludarabine/melphalan+/-low-dose TBI. [Bone Marrow Transplant] Abstract

A Novel Method to Evaluate Prethawing Viability of Cryopreserved CD34⁺ Hematopoietic Stem Cells for Autologous Transplantation

61 apheresis procedures of 42 patients undergoing autologous hematopoietic stem cell transplant were analyzed. Viable CD34⁺ cells were quantified with flow cytometry before controlled rate freezing, after ten days of storage, and before reinfusion. [Transfusion] Abstract

Development of Immortalized Human Hepatocyte-Like Hybrid Cells by Fusion of Multi-Lineage Progenitor Cells with Primary Hepatocytes

Scientists describe a novel technique to produce expandable and functional hepatocyte-like cells from the fusion of an immortalized human umbilical cord blood derived cell line to normal human primary hepatocytes. Multi-lineage progenitor cells comprised a small subset of mesenchymal-like cells isolated from human umbilical cord blood. [PLoS One] Full Article

Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations

Both genome-edited infant and adult KMT2Ar cells showed monoclonal outgrowth with an immature morphology, myelomonocytic phenotype and elevated KMT2Ar target gene expression comparable to patient cells. [Cells] Full Article

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Immunomodulatory Properties of Amniotic Membrane Derivatives and Their Potential in Regenerative Medicine

Among other sources, amniotic-derived products have been used for decades in various fields of medicine as a biomaterial for the wound care and tissue replacement. The authors summarize beneficial properties of human amniotic membrane and its derivatives and discuss their potential in regenerative medicine. [Curr Diab Rep] Abstract

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Cellenkos^®, Inc. Announces FDA Clearance to Initiate Phase I Double- Blinded, Randomized, Placebo-Controlled Trial of Cryopreserved Cord Blood-Derived T-Regulatory Cells (CK0802) for Treatment of COVID-19 Associated Acute Respiratory Distress Syndrome

Cellenkos™ announced that the FDA has cleared the way to initiate a Phase I clinical trial of CK0802 for treatment of COVID-19 associated acute respiratory distress syndrome. [Cellenkos^®, Inc.] Press Release

Baylx, Inc. Received US FDA Clearance of IND Application for Cord Tissue Mesenchymal Stem Cells

Baylx, Inc. announced that the FDA has cleared Baylx’s Investigational New Drug (IND) application for BX-U001, a fresh, non-frozen human umbilical cord tissue mesenchymal stem cells product in patients with rheumatoid arthritis. [Baylx, Inc.] Press Release

NIH Strengthens Policies to Alert Agency to Sexual Harassment by Grantees

The National Institutes of Health (NIH) is tightening grant rules that until now have sometimes left the agency in the dark about sexual harassment cases involving researchers it supports. [ScienceInsider] Editorial

MIT, Guided by Open Access Principles, Ends Elsevier Negotiations

Institute ends negotiations for a new journals contract in the absence of a proposal aligning with the MIT Framework for Publisher Contracts. [MIT News] Editorial

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NEW Research Technician – Cord Blood Preperation (Duke University)

NEW Instructor – Stem Cell Products (University of Colorado, Denver)

Professor – Hematology-Oncology (Karolinska Institutet)

Postdoctoral Fellow – Cell Biology (Tulane University School of Medicine)

Postdoctoral Fellow – Molecular Hematology (Heidelberg University Hospital)

Department Head – Hematological Cancer (Ichnos)

Deputy Director – Division of Blood Diseases and Resources (NIH National Heart, Lung, and Blood Institute)

Postdoctoral Position – Tumor Immunology (University of Maryland)

Senior Scientist – Cell Engineering (Merck & Co., Inc.)

Postdoctoral Researcher – Leukemia (Josep Carreras Leukaemia Research Institute)

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