Cord Blood News Volume 12.23 | Jun 18 2020

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    2020-06-18| CNB 12.23

    Cord Blood News by STEMCELL Technologies
    Vol. 12.23 – 18 June, 2020
    TOP STORY

    Cryopreserved Human Oocytes and Cord Blood Cells Can Produce Somatic Cell Nuclear Transfer-Derived Pluripotent Stem Cells with a Homozygous HLA Type

    Researchers applied a modified derivation method to the pluripotent stem cell line and first obtained human somatic cell nuclear transfer-PSC lines derived from both donated cryopreserved oocytes and cord blood cells with a homozygous human leukocyte antigen type.
    [Stem Cell Reports]

    Full Article

    Getting enough cord blood HSCs for transplantation isn't easy. But she's paving the way. Watch Suzan Imren's webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

    Intravenous delivery of immunity- and matrix-regulatory cells, derived from human embryonic stem cells, inhibited both pulmonary inflammation and fibrosis in mouse models of lung injury, and significantly improved the survival rate of the recipient mice in a dose-dependent manner, likely through paracrine regulatory mechanisms.
    [Cell Research]

    Full Article

    Allogeneic Cord Blood Transfusions Prevent Fetal Hemoglobin Depletion in Preterm Neonates. Results of the CB-TrIP Study

    Investigators monitored fetal hemoglobin levels in 25 preterm neonates until 36 weeks of post‐menstrual age; patients received repeated red blood cell (RBC) units from allogeneic cord blood (cord‐RBCs) or from adult donors, depending on whether cord‐RBCs were available.
    [British Journal of Haematology]

    Abstract

    Hypoxia-Preconditioned Placenta-Derived Mesenchymal Stem Cells Rescue Optic Nerve Axons via Differential Roles of Vascular Endothelial Growth Factor in an Optic Nerve Compression Animal Model

    Scientists established a hypoxia-preconditioned strain using a hypoxic chamber. The human placenta–derived stem cells were exposed to short-term hypoxic conditions of 2.2% O2 and 5.5% CO2.
    [Molecular Neurobiology]

    Abstract

    Plasma Membrane Vesicles of Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Acetaminophen-Induced Damage in HepG2 Cells: A Novel Stem Cell Therapy

    PMVs from human umbilical cord (hUC) MSCs were prepared with an improved procedure including a chemical enucleation step followed by a mechanical extrusion. Plasma membrane vesicles of hUCMSCs were characterized and supplemented to hepatocyte cultures.
    [Stem Cell Research & Therapy]

    Full Article

    Proteomic Profiling of Striatal Tissue of a Rat Model of Parkinson’s Disease after Implantation of Collagen-Encapsulated Human Umbilical Cord Mesenchymal Stem Cells

    Human umbilical cord-MSCs were encapsulated into collagen hydrogels and implanted into the striatum of hemi‐parkinsonian male Sprague Dawley rats. One or 14 days after implantation, the area of interest was dissected using a cryostat.
    [Journal of Tissue Engineering and Regenerative Medicine]

    Abstract

    Human Umbilical Cord Blood–Derived MSCs Exosome Attenuate Myocardial Injury by Inhibiting Ferroptosis in Acute Myocardial Infarction Mice

    Compared with sham or normoxia groups, RT-PCR and western blotting showed that divalent metal transporter 1 expression was significantly increased, and Prussian blue staining, ferrous iro, MDA, and GSH level detection demonstrated that ferroptosis occurred in the infraction myocardium and in cardiomyocyte following hypoxia-induced injury.
    [Cell Biology and Toxicology]

    Full Article

    The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    REVIEWS

    Cross Talk between Mesenchymal and Glioblastoma Stem Cells: Communication beyond Controversies

    The authors discuss recent findings on the complex nature of MSCs, focusing on their elusive impact on glioblastoma progression and aggressiveness by direct cell‐cell interaction and via secretome, also facing the perspectives and challenges in treatment strategies.
    [Stem Cells Translational Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    Emmes Announces Its Work on a Phase III Clinical Trial for Breakthrough Therapy Designation Product

    Emmes announced that it provided the Phase III clinical trial support for a new investigational cell therapy that offers a promising treatment opportunity for patients who need an allogeneic bone marrow transplant.
    [Emmes (PR Newswire, Inc.)]

    Press Release

    Hong Kong’s Contentious National Security Law Concerns Some Academics

    China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
    [Nature News]

    Editorial

    FEATURED EVENT

    International Society for Stem Cell Research (ISSCR) Virtual Annual Meeting 2020

    2020-06-23 – 2020-06-27
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Immune Privilege of the Stem Cell Niche

    Columbia University – New York, New York, United States

    Research Technician – Cord Blood Preperation

    Duke University – Durham, North Carolina, United States

    Instructor – Stem Cell Products

    University of Colorado – Denver, Colorado, United States

    Professor – Hematology-Oncology

    Karolinska Institutet – Solna, Sweden

    Postdoctoral Fellow – Cell Biology

    Tulane University School of Medicine – New Orleans, Los Angeles, United States

    Postdoctoral Fellow – Molecular Hematology

    Heidelberg University Hospital – Heidelberg, Germany

    Department Head – Hematological Cancer

    Ichnos – Lausanne, Switzerland

    Deputy Director – Division of Blood Diseases and Resources

    NIH National Heart, Lung, and Blood Institute – Bethesda, Maryland, United States

    Postdoctoral Position – Tumor Immunology

    University of Maryland – Baltimore, Maryland, United States

    Senior Scientist – Cell Engineering

    Merck & Co., Inc. – Kenilworth, New Jersey, United States

    Postdoctoral Researcher – Leukemia

    Josep Carreras Leukaemia Research Institute – Barcelona, Spain

    > See All Jobs

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