| Vol. 12.23 – 18 June, 2020 |
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| Researchers applied a modified derivation method to the pluripotent stem cell line and first obtained human somatic cell nuclear transfer-PSC lines derived from both donated cryopreserved oocytes and cord blood cells with a homozygous human leukocyte antigen type. [Stem Cell Reports] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Intravenous delivery of immunity- and matrix-regulatory cells, derived from human embryonic stem cells, inhibited both pulmonary inflammation and fibrosis in mouse models of lung injury, and significantly improved the survival rate of the recipient mice in a dose-dependent manner, likely through paracrine regulatory mechanisms. [Cell Research] |
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| Investigators monitored fetal hemoglobin levels in 25 preterm neonates until 36 weeks of post‐menstrual age; patients received repeated red blood cell (RBC) units from allogeneic cord blood (cord‐RBCs) or from adult donors, depending on whether cord‐RBCs were available. [British Journal of Haematology] |
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| Scientists established a hypoxia-preconditioned strain using a hypoxic chamber. The human placenta–derived stem cells were exposed to short-term hypoxic conditions of 2.2% O2 and 5.5% CO2. [Molecular Neurobiology] |
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| PMVs from human umbilical cord (hUC) MSCs were prepared with an improved procedure including a chemical enucleation step followed by a mechanical extrusion. Plasma membrane vesicles of hUCMSCs were characterized and supplemented to hepatocyte cultures. [Stem Cell Research & Therapy] |
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| Human umbilical cord-MSCs were encapsulated into collagen hydrogels and implanted into the striatum of hemi‐parkinsonian male Sprague Dawley rats. One or 14 days after implantation, the area of interest was dissected using a cryostat. [Journal of Tissue Engineering and Regenerative Medicine] |
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| Compared with sham or normoxia groups, RT-PCR and western blotting showed that divalent metal transporter 1 expression was significantly increased, and Prussian blue staining, ferrous iro, MDA, and GSH level detection demonstrated that ferroptosis occurred in the infraction myocardium and in cardiomyocyte following hypoxia-induced injury. [Cell Biology and Toxicology] |
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| The authors discuss recent findings on the complex nature of MSCs, focusing on their elusive impact on glioblastoma progression and aggressiveness by direct cell‐cell interaction and via secretome, also facing the perspectives and challenges in treatment strategies. [Stem Cells Translational Medicine] |
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| Emmes announced that it provided the Phase III clinical trial support for a new investigational cell therapy that offers a promising treatment opportunity for patients who need an allogeneic bone marrow transplant. [Emmes (PR Newswire, Inc.)] |
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| China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected. [Nature News] |
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2020-06-23 – 2020-06-27 Virtual |
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| Columbia University – New York, New York, United States |
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| Duke University – Durham, North Carolina, United States |
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| University of Colorado – Denver, Colorado, United States |
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| Karolinska Institutet – Solna, Sweden |
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| Tulane University School of Medicine – New Orleans, Los Angeles, United States |
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| Heidelberg University Hospital – Heidelberg, Germany |
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| Ichnos – Lausanne, Switzerland |
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| NIH National Heart, Lung, and Blood Institute – Bethesda, Maryland, United States |
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| University of Maryland – Baltimore, Maryland, United States |
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| Merck & Co., Inc. – Kenilworth, New Jersey, United States |
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| Josep Carreras Leukaemia Research Institute – Barcelona, Spain |
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