Cord Blood News Volume 12.27 | July 16

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    CBN Volume 12.27 | Jul 16


    Cord Blood News by STEMCELL Technologies
    TOP STORY
    Vol. 12.27 – 16 July, 2020

    GvHD-Free, Relapse-Free Survival Provides Novel Clues for Optimizing Allogeneic-HSCT for Adult T-Cell Leukemia/Lymphoma

    The authors performed a nationwide retrospective study of graft-versus-host disease (GvHD)-free, relapse-free survival of patients with allogeneic hematopoietic stem cell transplantation (HSCT)-treated adult T-cell leukemia/lymphoma.
    [Bone Marrow Transplantation]

    Abstract

    Kevin Shoulars found a faster, more reproducible way to assess the potency of core blood units for transplant. Watch the webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Umbilical Cord-Mesenchymal Stem Cell-Conditioned Medium Improves Insulin Resistance in C2C12 Cell

    Effects of umbilical cord-mesenchymal stem cell-conditioned medium on insulin resistance were evaluated using glucose uptake, glucose transporter type 4 translocation, the insulin-signaling pathway, and mitochondrial contents and functions in C2C12 cell.
    [Diabetes & Metabolism Journal]

    Full Article

    Insights into the Hematopoietic Regulatory Activities of Osteoblast by Secretomics

    The authors characterized the hematopoietic supporting activity of mesenchymal stromal cells‐derived osteoblast (M‐OST) conditioned media by comparing the secretome of M‐OST to that of their precursor.
    [Proteomics]

    Abstract

    Maternal Diabetes Alters microRNA Expression in Fetal Exosomes, Human Umbilical Vein Endothelial Cells and Placenta

    miRNA abundance was quantified using real-time PCR from RNA isolated from umbilical cord serum exosomes, human umbilical vein endothelial cells, and placenta exposed to diabetes or normoglycemia during pregnancy.
    [Pediatric Research]

    Abstract

    Expression of ADP Receptor P2Y12, Thromboxane A2 Receptor and C-Type Lectin-Like Receptor 2 in Cord Blood-Derived Megakaryopoiesis

    Investigators determined mean fluorescence intensity values of FITC, PE, or APC labeled antibodies binding to the receptors on platelets of 90 healthy donors.
    [Platelets]

    Abstract

    Effect of Delayed Cord Clamping on Stem Cell Transfusion and Hematological Parameters in Preterm Infants with Placental Insufficiency: A Pilot Randomized Trial

    Scientists studied the effect of delayed cord clamping on stem cell transfusion, hematological parameters, and clinical outcomes in pre-term infants born to mothers with placental insufficiency.
    [European Journal of Pediatrics]

    Abstract

    Human Amniotic Epithelial Cells Promote the Proliferation of Human Corneal Endothelial Cells by Regulating Telomerase Activity via the Wnt/β-Catenin Pathway

    Human amniotic epithelial cells (HAECs) and human corneal endothelial cells were isolated from donated tissue samples and were cultured; the collected HAEC culture medium was added to the human corneal endothelium medium to establish the HAEC-CM system.
    [Current Eye Research]

    Abstract

    Reduced-Intensity Single-Unit Unrelated Cord Blood Transplant with Optional Immune Boost for Nonmalignant Disorders

    Investigators prospectively evaluated a novel reduced-intensity conditioning regimen of alemtuzumab, hydroxyurea, fludarabine, melphalan, and thiotepa with a single-unit umbilical cord blood graft in 44 consecutive patients with inborn errors of metabolism, immunity, or hematopoiesis.
    [Blood Advances]

    Full ArticlePress Release

    Get High Cell Purity and Recovery with Lymphoprep™
    REVIEWS

    Safety and Efficacy of Cell Therapies in Pediatric Heart Disease: A Systematic Review and Meta-Analysis

    In this meta-analysis, cell-based therapies were found to be safe and improved specific measures of cardiac function. Implications from this review may provide methodologic recommendations for future clinical trials.
    [Stem Cell Research & Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Open-Access Plan S to Allow Publishing in Any Journal

    Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing.
    [Nature News]

    Editorial

    During the Pandemic, Students Do Field and Lab Work without Leaving Home

    Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences.
    [Science Insider]

    Editorial

    An Analysis of Ways to Decarbonize Conference Travel after COVID-19

    The COVID-19 pandemic has forced us to rethink what constitutes necessary travel. Many of this year’s conferences have been cancelled. Some have gone virtual. Nature presents an original analysis of the potential emissions savings of doing things differently.
    [Nature News]

    Editorial

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    JOB OPPORTUNITIES

    Postdoctoral Researcher – Red Blood Cell Signaling and Physiology

    University of Maryland – Baltimore, Maryland, United States

    Postdoctoral Fellow – Pluripotent Stem Cell Biology and Cardiac Disease Modeling

    Northwestern University – Chicago, Illinois, United States

    Postdoctoral Position – Immune Privilege of the Stem Cell Niche

    Columbia University – New York, New York, United States

    Research Technician – Cord Blood Preparation

    Duke University – Durham, North Carolina, United States

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    University of Colorado – Denver, Colorado, United States

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