 | | Vol. 8.31 – 20 August, 2020 |
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| Investigators found lipopolysaccharide significantly increased inflammatory factors, administration of exosomes released by human umbilical cord MSCs successfully improved lung morphometry.
[Cell Death & Disease] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| A novel strategy was developed to support ex vivo expansion of hematopoietic stem and progenitor cells by coculture with engineered human umbilical arterial endothelial cells, which expressed E4ORF1 stably by using a retroviral system.
[Stem Cell Research & Therapy] |
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| SIRT1 was overexpressed in human umbilical cord (UC) MSCs to establish SIRT1-modified hUCMSCs. Co-culture and transplantation experiments were performed in TGF-β-stimulated Met-5A cells and peritoneal damage rodent model to assess the therapeutic potential of SIRT1-modified hUCMSCs for peritoneal fibrosis through qPCR, Western blot, and peritoneal function analyses.
[Stem Cell Research & Therapy] |
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| Investigators studied the expression of stemness-related genes, epigenetic regulators, miRNAs related to stemness, exosomes, the cell-cycle regulators p21 and p53, and the senescence-associated genes.
[Cells] |
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| Using nationwide registration data, scientists compared the transplant outcomes of patients who developed graft failure and underwent salvage cord blood transplanatation using immunosuppressants, including calcineurin (CNI) alone; CNI plus methotrexate; and CNI plus mycophenolate mofetil.
[Bone Marrow Transplantation] |
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| In vitro experiments included 2 groups: peripheral blood mononuclear cells (PBMCs) after mobilization and human umbilical cord blood-derived MSCs co-cultured with PBMCs.
[Cytotherapy] |
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| Scientists showed that following in vitro expansion, Wharton’s jelly MSCs were more effective than other sources of MSCs. Cell to cell contact or secretion of soluble factors and exosomes were the main approaches of MSCs in applying their effects.
[Immunological investigations] |
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| Investigators highlight the bidirectional communication of glioma cells and tumor-associated immune cells, the inflammatory mediators enabling leukocytes and transplantable MSC migration, and review preclinical and human clinical trials using MSCs as delivery vehicles.
[Mayo Clinic Proceedings] |
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| IsoPlexis announced a collaboration with Lonza to use IsoPlexis’ IsoLight platform. This automated functional proteomics analysis platform will provide quality analytics for cell therapy products generated on Lonza’s Cocoon® Platform, an automated, highly flexible cell therapy manufacturing platform.
[Isoplexis (PR Newswire Association LLC)] |
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| July 8 – July 10, 2021
Boston, Massachusetts, United States |
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| | Memorial Sloan Kettering Cancer Center – New York City, New York, United States |
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| | Myeloid Therapeutics – Cambridge, Massachusetts, United States |
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| | University of Massachusetts – Amherst, Massachusetts, United States |
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| | Huntington Medical Research Institutes – Pasadena, California, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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