 | | Vol. 8.33 – 3 September, 2020 |
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| By exploiting genome editing technology, human umbilical cord-derived MSCs secreting an angiogenic factors or an anti-inflammatory factor were generated for therapeutic application in acute kidney injury.
[Kidney International] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| 47 patients were identified, and five were re-transplanted. 68% were male. The median age at diagnosis was 0.6 years, and for hematopoietic stem cell transplantation was 1.4 years.
[Journal of Clinical Immunology] |
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| 26 patients underwent allogeneic hematopoietic stem cell transplant (HSCT). HSCT successfully supported survival using a variety of cell sources from sibling, family and unrelated donors.
[Journal of Clinical Immunology] |
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| Scientists found that stepwise treatment with six signaling pathway inhibitors along with nicotinamide increased retinal pigment epithelial (RPE) differentiation efficiency, enabling the RPE sheet generation at high purity without manual selection.
[Scientific Reports] |
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| Isolates from the medicinal plants Trillium tschonoskii were tested for their effect on the expansion of human cord blood CD34+ hematopoietic stem and progenitor cells.
[Journal of Natural Products] |
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| In two–five-month-old mdx mice intravenously injected with 1 × 105 Wharton’s jelly-derived MSCs, fibrosis intensity and accumulation of calcium/necrotic fibers were significantly decreased.
[International Journal of Molecular Sciences] |
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| Scientists analyzed whether dermal extracellular matrix support the cardiac differentiation of CardiopoieticAF stem cells. These perinatal stem cells, which can be easily isolated without ethical or safety limitations, displayed a high cardiac differentiative potential.
[International Journal of Molecular Sciences] |
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| Bone marrow-, adipose tissue-, or umbilica cord-MSCs were isolated each from 3 different healthy donors. The gene expression and protein secretion were analyzed at basal level, along with TNFα-, IL-1β- and SAA- stimulated cells using real-time PCR and Luminex technology.
[Current Research in Translational Medicine] |
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| Scientists focus on both autogenous and artificial hematopoietic reprogramming under physiological and pathological conditions that is mainly directed by the actions of transcription factors, chemical compounds, or extracellular cytokines.
[Trends in Cell Biology] |
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| Avalon GloboCare Corp. announced the launch of its new allogeneic MSC therapeutic platform. Avalon plans to develop the MSC platform as a potential therapy for COVID-19, the disease caused by the SARS-CoV-2, and for bone marrow transplant related complications of acute graft versus host disease.
[Avalon GloboCare Corp. ] |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | Pennsylvania State University – Philadelphia, Pennsylvania, United States |
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| | Memorial Sloan Kettering Cancer Center – New York City, New York, United States |
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| | Myeloid Therapeutics – Cambridge, Massachusetts, United States |
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| | University of Massachusetts – Amherst, Massachusetts, United States |
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