Cord Blood News Volume 12.35 | Sep 10 2020

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    CBN 8.34 | Sep 10


    Cord Blood News by STEMCELL Technologies
    Vol. 8.34 – 10 September, 2020
    TOP STORY

    Targeting a Cytokine Checkpoint Enhances the Fitness of Armored Cord Blood CAR-NK Cells

    To broaden the clinical impact of checkpoint targeting, investigators devised a strategy that coupled targeting of the cytokine-inducible SH2-containing protein, a key negative regulator of interleukin-15 signaling, with fourth generation ‘armored’ chimeric antigen receptor engineering of cord blood derived natural killer cells.
    [Blood]

    Abstract

    Request your free copy of the 'Bone Marrow Niches and HSC Fates' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    Regeneration
    of a Full-Thickness Defect of Rotator Cuff Tendon with Freshly Thawed Umbilical Cord-Derived Mesenchymal Stem Cells in a Rat Model

    Researchers evaluated morphology, viability, and proliferation of cultured umbilical cord-derived MSCs and freshly thawed umbilical cord-derived MSCs at passage 10 in vitro.
    [Stem Cell Research & Therapy]

    Full Article

    hUMSCs
    Regulate the Differentiation of Ovarian Stromal Cells via TGF-β1/Smad3 Signaling Pathway to Inhibit Ovarian Fibrosis to Repair Ovarian Function in POI Rats

    The authors investigated whether the recovery of ovarian function in primary ovarian insufficiency rats was related to the inhibition of tissue fibrosis following human umbilical cord MSC transplantation.
    [Stem Cell Research & Therapy]

    Full Article

    Human
    Wharton’s Jelly Mesenchymal Stem Cell-Mediated Sciatic Nerve Recovery Is Associated with the Upregulation of Regulatory T Cells

    The effects of human Wharton’s jelly-MSC on innate immunity, represented by macrophages, natural killer cells, and dendritic cells, as well as on adaptive immunity, represented by CD4+ T, CD8+ T, B, and regulatory T cells, were examined using flow cytometry.
    [International Journal of Molecular Sciences]

    Full Article

    Comparative
    Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton’s Jelly-Derived Mesenchymal Stem Cells

    A proteomic approach was employed to identify specific proteins differentially expressed by wharton’s jelly derived-MSCs in comparison to those by neonatal foreskin and adult skin fibroblasts.
    [International Journal of Molecular Sciences]

    Full Article

    ABCA1
    Plays an Anti-Inflammatory Role by Affecting TLR4 at the Feto–Maternal Interface

    Primary amniotic mesenchymal cells (AMCs), chorion cells and decidual cells were isolated from placental membranes of women with uncomplicated pregnancies at full-term using enzymatic digestion.
    [Life Sciences]

    Abstract

    RASL11B
    Gene Enhances Hyaluronic Acid-Mediated Chondrogenic Differentiation in Human Amniotic Mesenchymal Stem Cells via the Activation of Sox9/ERK/Smad Signals

    Investigators elucidated the molecular mechanisms, whereby hyaluronic acid, a main extracellular matrix component of articular cartilage, promotes the chondrogenic differentiation of human amniotic mesenchymal stem cells.
    [Experimental Biology and Medicine]

    Abstract

    Learn more about cGMP-manufactured StemSpanâ„¢-ACF Without Phenol Red for culturing hematopoietic cell therapy products
    REVIEWS

    Cartilage
    Repair Using Stem Cells & Biomaterials: Advancement from Bench to Bedside

    Scientists highlight the chondrogenic potential of MSCs, factors guiding in vitro chondrogenic differentiation, biomaterials available for cartilage repair, their current market status, and the outcomes of major clinical trials.
    [Molecular Biology Reports]

    Abstract

    INDUSTRY AND POLICY NEWS

    Celularity
    Doses First Patient in Clinical Trial Evaluating CYNK-001 in COVID-19 Patients

    Celularity announced that the first patient was dosed in a Phase I/II study of human placental hematopoietic stem cell derived NK cells for the treatment of adults with COVID-19 as part of a national clinical trial.
    [Celularity Inc.]

    Press Release

    Cymerus MSCs Demonstrate Efficacy in Preclinical Lung Disease Study

    Cynata Therapeutics Limited has announced positive efficacy data from a study of its iPSC-derived Cymerusâ„¢ MSCs in a preclinical rodent model of idiopathic pulmonary fibrosis.
    [Cynata Therapeutics Limited (GlobeNewswire, Inc.)]

    Press Release

    FEATURED EVENT

    i-Vaccines 2021: International Vaccines & Virology Conference

    June 10-11, 2021
    London, England, United Kingdom


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    JOB OPPORTUNITIES

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    Pennsylvania State University – Philadelphia, Pennsylvania, United States

    Tenure-Track Faculty Positions – Stem Cell Biology

    Memorial Sloan Kettering Cancer Center – New York City, New York, United States

    Associate Scientist – In Vivo
    Pharmacology

    Myeloid Therapeutics – Cambridge, Massachusetts, United States

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