| Vol. 8.34 – 10 September, 2020 |
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| To broaden the clinical impact of checkpoint targeting, investigators devised a strategy that coupled targeting of the cytokine-inducible SH2-containing protein, a key negative regulator of interleukin-15 signaling, with fourth generation ‘armored’ chimeric antigen receptor engineering of cord blood derived natural killer cells. [Blood] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers evaluated morphology, viability, and proliferation of cultured umbilical cord-derived MSCs and freshly thawed umbilical cord-derived MSCs at passage 10 in vitro. [Stem Cell Research & Therapy] |
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| The authors investigated whether the recovery of ovarian function in primary ovarian insufficiency rats was related to the inhibition of tissue fibrosis following human umbilical cord MSC transplantation. [Stem Cell Research & Therapy] |
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| The effects of human Wharton’s jelly-MSC on innate immunity, represented by macrophages, natural killer cells, and dendritic cells, as well as on adaptive immunity, represented by CD4+ T, CD8+ T, B, and regulatory T cells, were examined using flow cytometry. [International Journal of Molecular Sciences] |
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| A proteomic approach was employed to identify specific proteins differentially expressed by wharton’s jelly derived-MSCs in comparison to those by neonatal foreskin and adult skin fibroblasts. [International Journal of Molecular Sciences] |
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| Primary amniotic mesenchymal cells (AMCs), chorion cells and decidual cells were isolated from placental membranes of women with uncomplicated pregnancies at full-term using enzymatic digestion. [Life Sciences] |
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| Investigators elucidated the molecular mechanisms, whereby hyaluronic acid, a main extracellular matrix component of articular cartilage, promotes the chondrogenic differentiation of human amniotic mesenchymal stem cells. [Experimental Biology and Medicine] |
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| Scientists highlight the chondrogenic potential of MSCs, factors guiding in vitro chondrogenic differentiation, biomaterials available for cartilage repair, their current market status, and the outcomes of major clinical trials. [Molecular Biology Reports] |
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| Celularity announced that the first patient was dosed in a Phase I/II study of human placental hematopoietic stem cell derived NK cells for the treatment of adults with COVID-19 as part of a national clinical trial. [Celularity Inc.] |
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| Cynata Therapeutics Limited has announced positive efficacy data from a study of its iPSC-derived Cymerusâ„¢ MSCs in a preclinical rodent model of idiopathic pulmonary fibrosis. [Cynata Therapeutics Limited (GlobeNewswire, Inc.)] |
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| June 10-11, 2021 London, England, United Kingdom |
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| University of Washington – Seattle, Washington, United States |
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| Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| Pennsylvania State University – Philadelphia, Pennsylvania, United States |
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| Memorial Sloan Kettering Cancer Center – New York City, New York, United States |
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| Myeloid Therapeutics – Cambridge, Massachusetts, United States |
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