Cord Blood News Volume 12.36 | Sep 17, 2020

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    2020-09-17 | CBN 12.36


    Cord Blood News by STEMCELL Technologies
    Vol. 12.36 – 17 September, 2020
    TOP STORY

    Activation of Wnt Signaling by Amniotic Fluid Stem Cell-Derived Extracellular Vesicles Attenuates Intestinal Injury in Experimental Necrotizing Enterocolitis

    Scientists demonstrated that amniotic fluid stem cells and extracellular vesicles attenuated necrotizing enterocolitis intestinal injury by activating the Wnt signaling pathway.
    [Cell Death & Disease]

    Full Article


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    PUBLICATIONSRanked by the impact factor of the journal

    Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity

    Researchers extensively compared the physiological functions of human Wharton’s jelly-derived mesenchymal stem cells in a xeno-free medium and a medium containing 10% fetal bovine serum.
    [Journal of Clinical Medicine]

    Full Article

    Umbilical Cord Mesenchymal Stem Cells Protect Thymus Structure and Function in Aged C57 Mice by Downregulating Aging-Related Genes and Upregulating Autophagy- and Anti-Oxidative Stress-Related Genes

    Investigators studied the effect of allogeneic umbilical cord mesenchymal stem cell transplantation on the structure and function of the thymus in aged C57 mice and provided a new method for the treatment of senile thymic atrophy.
    [Aging]

    Full Article

    TNFSF15 Facilitates Human Umbilical Cord Blood Hematopoietic Stem Cell Expansion by Activating Notch Signal Pathway

    The authors report that TNFSF15, a member of the tumor necrosis factor superfamily, promoted the expansion of human umbilical cord blood‐derived hematopoietic stem cells.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Advantage of Fat-Derived CD73 Positive Cells from Multiple Human Tissues, Prospective Isolated Mesenchymal Stromal Cells

    CD73-positive population from various tissues existed individually in flowcytometric pattern, especially subcutaneous fat- and amniotic-derived cells showed the highest enrichment of CD73-positive cells.
    [Scientific Reports]

    Full Article

    Successful Cord Blood Transplantation for Myelodysplastic Syndrome Complicated by Mycobacterium Kansasii Pneumonia

    Investigators report a case of myelodysplastic syndrome treated by umbilical cord blood transplantation after Mycobacterium kansasii pneumonia.
    [Transplant Infectious Disease]

    Abstract

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    REVIEWS

    Exploring the NK Cell Platform for Cancer Immunotherapy

    A wide variety of sources of therapeutic natural killer (NK) cells are currently being tested clinically, including haploidentical NK cells, umbilical cord blood NK cells, stem cell-derived NK cells, NK cell lines, adaptive NK cells, cytokine-induced memory-like NK cells and chimeric antigen receptor NK cells.The authors highlight the variety of ways in which diverse NK cell products and their auxiliary therapeutics are being leveraged to target human cancers.
    [Nature Reviews Clinical Oncology]

    Abstract

    INDUSTRY AND POLICY NEWS

    FDA Approves Study to Investigate the Use of Cell Therapy to Treat COVID-19 Related Multisystem Inflammatory Syndrome in Children (MIS-C)

    The Cura Foundation in collaboration with The Marcus Foundation, Sanford Health and Alliance for Cell Therapy Now, is supporting a clinical trial of human cord tissue mesenchymal stromal cells to treat children with Multisystem Inflammatory Syndrome in Children.
    [Alliance for Cell Therapy Now (PR Newswire Association LLC.)]

    Press Release

    FEATURED EVENT

    Cell Biology 2020

    September 23
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral / PhD Student – Placental Vascular Immune Response

    Purdue University – West Lafayette, Indiana, United States

    Associate Scientist – In Vivo Pharmacology

    Myeloid Therapeutics – Cambridge, Massachusetts, United States

    Postdoctoral Associate – NOTCH1- Mediated Leukemogenesis

    University of Massachusetts – Amherst, Massachusetts, United States

    Clinical Nurse – Stem Cell Transplantation and Cellular Therapy

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Position – iPSCs and Endothelial Cells

    Huntington Medical Research Institutes – Pasadena, California, United States

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