Cord Blood News Volume 12.39 | Oct 8 2020

May 12, 2022

2020-10-08 | CBN 12.39

Cord Blood News by STEMCELL Technologies

Vol. 12.39 – 8 October, 2020

TOP STORY

In Vivo
CRISPR/Cas9 Targeting of Fusion Oncogenes for Selective Elimination of Cancer Cells

Researchers devised a simple, efficient and non-patient-specific gene-editing strategy through targeting of two introns of the genes involved in the rearrangement, allowing for robust disruption of the fusion oncogenes specifically in cancer cells.
[Nature Communications]

Full Article Press Release

Getting enough cord blood HSCs for transplantation isn't easy. But she's paving the way. Watch Suzan Imren's webinar.

PUBLICATIONSRanked by the impact factor of the journal

Immediate
and Durable Effects of Maternal Tobacco Consumption Alter Placental DNA Methylation in Enhancer and Imprinted Gene-Containing Regions

Investigators combined the analysis of placenta epigenomic data with newly generated DNA methylation data obtained from 568 pregnant women, the largest cohort to date, either actively smoking during their pregnancy or formerly exposed to tobacco smoking.
[BMC Medicine]

Full Article

Derivation
of Three Human Induced Pluripotent Stem Cell Lines (JUCTCi014-A, JUCTCi015-A, JUCTCi016-a) from Mesenchymal Stem Cells (MSCs) Derived from Bone Marrow, Adipose Tissue and Wharton’s Jelly Samples

Researchers created human induced pluripotent stem cells (hiPSCs) from different MSC sources to evaluate the capacity of MSC-derived iPSCs to differentiate into any cell type of the human body and to serve as an alternative source for iPSC generation.
[Journal of Materials Chemistry B]

Full Article

UM171-Expanded
Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections

Scientists assessed T cell reconstitution in patients transplanted with UM171-expanded cord blood (CB) grafts and retrospectively compared it to that of patients receiving unmanipulated CB transplants.
[Biology of Blood and Marrow Transplantation]

Full Article Graphical Abstract

Nanographene Oxide-Calcium Phosphate to Inhibit Staphylococcus aureus
Infection and Support Stem Cells for Bone Tissue Engineering

Investigators developed an injectable and mechanically strong calcium phosphate bone cement‐chitosan paste containing graphene oxide and investigated the inhibition of Staphylococcus aureus infection and the promotion of human umbilical cord MSCs for bone regeneration.
[Journal of Tissue Engineering and Regenerative Medicine]

Abstract

Spatio-Temporal
Metabolokinetics and Efficacy of Human Placenta-Derived Mesenchymal Stem/Stromal Cells on Mice with Refractory Crohn’s-Like Enterocutaneous Fistula

Researchers systematically illuminated the spatio-temporal biofunction and mechanism of dual-fluorescence expressing placenta-derived MSCs on enterocutaneous fistula mice.
[Stem Cell Reviews and Reports]

Abstract

Mesenchymal
Stem Cells-Derived Mitochondria Transplantation Mitigates I/R-Induced Injury, Abolishes I/R-Induced Apoptosis, and Restores Motor Function in Acute Ischemia Stroke Rat Model

Investigators report that the mitochondrial transplantation ameliorated the reperfusion/ischemia-induced damages as reflected by declined blood creatine phosphokinase level, abolished apoptosis, decreased astroglyosis and microglia activation, reduced infarct size, and improved motor function.
[Brain Research Bulletin]

Abstract

Efficacy
of Allogeneic Cord Blood Platelet Gel on Wounds of Dystrophic Epidermolysis Bullosa Patients after Pseudosyndactyly Surgery

The authors investigated the therapeutic effects of allogeneic platelet gel prepared from umbilical cord blood in a group of children diagnosed with dystrophic epidermolysis bullosa eligible for surgical correction of pseudosyndactyly in the hand.
[Wound Repair and Regeneration]

Abstract

Kevin Shoulars found a faster, more reproducible way to assess the potency of core blood units for transplant. Watch the webinar.

REVIEWS

Cellular
Immunotherapies in Pre-Clinical Large Animal Models of Transplantation

Investigators highlight the contributions of large animal models to the development and fine-tuning of hematopoietic cell transplant and additional cellular therapies to improve organ transplantation outcomes.
[Biology of Blood and Marrow Transplantation]

Abstract

INDUSTRY AND POLICY NEWS

Gamida
Cell Announces Positive Topline Data on Secondary Endpoints from Phase III Clinical Study of Omidubicel in Patients with Hematologic Malignancies

Gamida Cell Ltd. announced that the Phase III study of omidubicel, an investigational advanced cell therapy in development as a potential life-saving treatment option for patients in need of bone marrow transplant, met all three of its secondary endpoints.
[Gamida Cell Ltd.]

Press Release

Affimed Announces Dosing of First Patient in Phase I Clinical Trial of Cord Blood-derived Natural Killer Cells in Combination with the Innate Cell Engager AFM13

Affimed N.V. announced that the first patient was successfully dosed with allogeneic cord blood-derived natural killer cells preloaded with AFM13 and has moved on to the AFM13 monotherapy phase of the treatment cycle. This therapy was developed through a research collaboration with The University of Texas MD Anderson Cancer Center.
[Affimed N.V.]

Press Release

Cynata
Stem Cells Test Positive for Heart Attack Repair

Cynata Therapeutics has produced trial results confirming the initial success of its Cymerus MSCs in restoring cardiac function following a heart attack.
[The West Australian]

Press Release

FEATURED EVENT

In Vivo
CRISPR/Cas9 Targeting of Fusion Oncogenes for Selective Elimination of Cancer Cells

Immediate
and Durable Effects of Maternal Tobacco Consumption Alter Placental DNA Methylation in Enhancer and Imprinted Gene-Containing Regions

Derivation
of Three Human Induced Pluripotent Stem Cell Lines (JUCTCi014-A, JUCTCi015-A, JUCTCi016-a) from Mesenchymal Stem Cells (MSCs) Derived from Bone Marrow, Adipose Tissue and Wharton’s Jelly Samples

UM171-Expanded
Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections

Nanographene Oxide-Calcium Phosphate to Inhibit Staphylococcus aureus
Infection and Support Stem Cells for Bone Tissue Engineering

Spatio-Temporal
Metabolokinetics and Efficacy of Human Placenta-Derived Mesenchymal Stem/Stromal Cells on Mice with Refractory Crohn’s-Like Enterocutaneous Fistula

Mesenchymal
Stem Cells-Derived Mitochondria Transplantation Mitigates I/R-Induced Injury, Abolishes I/R-Induced Apoptosis, and Restores Motor Function in Acute Ischemia Stroke Rat Model

Efficacy
of Allogeneic Cord Blood Platelet Gel on Wounds of Dystrophic Epidermolysis Bullosa Patients after Pseudosyndactyly Surgery

Cellular
Immunotherapies in Pre-Clinical Large Animal Models of Transplantation

Gamida
Cell Announces Positive Topline Data on Secondary Endpoints from Phase III Clinical Study of Omidubicel in Patients with Hematologic Malignancies

Affimed Announces Dosing of First Patient in Phase I Clinical Trial of Cord Blood-derived Natural Killer Cells in Combination with the Innate Cell Engager AFM13

Cynata
Stem Cells Test Positive for Heart Attack Repair

Keystone
Symposia: Emerging Cell Therapies: Realizing the Vision of NextGen Cell Therapeutics

> See All Events

Postdoctoral
Scientists – Stem Cell Factors in Epithelial Cancers

Faculty Position – Stem Cell Biology

Faculty Member – Cellular, Developmental, and Stem Cell Biology

Research Associate – Stem Cell Differentiation and Cancer Initiation

Postdoctoral
/ PhD Student – Placental Vascular Immune Response

> See All Jobs