Cord Blood News Volume 12.40 | Oct 15 2020

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    2020-10-14 | CBN 12.40


    Cord Blood News by STEMCELL Technologies
    Vol. 12.40 – 15 October, 2020
    TOP STORY

    Maternal
    HIV Status Skews Transcriptomic Response in Infant Cord Blood Monocytes Exposed to BCG

    HIV-unexposed and HIV-exposed uninfected infant cord blood monocytes were treated with Bacillus Calmette-Guerín (BCG) and transcriptionally profiled with the Nanostring nCounter platform. Differential expression and pathway enrichment analyses were performed, and transcripts were identified with enhanced or dampened BCG responses.
    [AIDS]

    Abstract

    The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    PUBLICATIONSRanked by the impact factor of the journal

    Biomimetic
    Microenvironmental Preconditioning Enhance Neuroprotective Properties of Human Mesenchymal Stem Cells Derived From Wharton’s Jelly (WJ-MSCs)

    WJ-MSCs were encapsulated in 3D hydrogels derived from human fibrin or platelet lysate and the oxygen level was adjusted to physiological normoxia (5% O2).
    [Scientific Reports]

    Full Article

    An
    Injectable Hyaluronan-Methylcellulose (HAMC) Hydrogel Combined with Wharton’s Jelly-Derived Mesenchymal Stromal Cells (WJ-MSCs) Promotes Degenerative Disc Repair

    Scientists investigated the effectiveness of hyaluronan–methylcellulose hydrogels loaded with WJ-MSCs in vitro and in a rat coccygeal intervertebral disc degeneration model.
    [International Journal of Molecular Sciences]

    Full ArticleGraphical Abstract

    Comparison
    Study of Stem Cell-Derived Extracellular Vesicles for Enhanced Osteogenic Differentiation

    Investigators evaluated the osteogenic capability of placental stem cell-derived extracellular vesicles (EVs) and compared them to the well-characterized bone marrow MSC-derived EVs. EVs were extracted from three designated time points after osteogenic differentiation.
    [Tissue Engineering]

    Abstract

    Human
    Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis

    Researchers found that human umbilical cord MSCs-derived small extracellular vesicles were successfully absorbed by lung tissue after intratracheal administration, and remained in the lungs for at least 72 hours.
    [Stem Cells and Development]

    Abstract

    Rabbit Umbilical Cord Mesenchymal Stem Cells: A New Option for Tissue Engineering

    The structure of the rabbit umbilical cord was analyzed and compared with that of human umbilical macroscopically and histologically. Scientists isolated, cultured, and identified the proliferative activity and immunological characteristics of rabbit umbilical cord MSCs in vitro using mixed lymphocyte reaction, flow cytometry, and ELISA test.
    [The Journal of Gene Medicine]

    Abstract


    View-On-Demand Webinar: Therapeutic Application of Endothelial Colony-Forming Cells. Watch Now.
    REVIEWS

    Therapeutic
    Advancement in Neuronal Transdifferentiation of Mesenchymal Stromal Cells for Neurological Disorders

    The authors give a brief description of MSCs, their sources and markers, and the different attempts that have been made towards achieving the goal of differentiating MSCs into neurons.
    [Journal of Molecular Neuroscience]

    Abstract

    Umbilical Cord: An Allogenic Tissue for Potential Treatment of COVID-19

    Scientists review the current evidences and explore the potential therapeutic use of allogenic umbilical cord (UC) and/or Wharton’s jelly (WJ)-derived MSCs for the treatment of COVID-19.
    [Human Cell]

    Full Article
    INDUSTRY AND POLICY NEWS

    Sorrento Adds Mesenchymal Stem Cell Program (MSC), Cleared for Phase I Trial by the FDA to the Pipeline of COVID-19 Focused Rescue Therapies

    Sorrento Therapeutics, Inc. announced that it has entered into an exclusive license agreement with Personalized Stem Cells, Inc. to acquire global rights to its adipose-derived MSCs for patients suffering from acute respiratory distress syndrome associated with COVID-19, which have been cleared for a Phase I clinical trial by the FDA.
    [Sorrento Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Cell Symposia: 20 Years of the Human Genome: From Sequence to Substance

    April 11 – April 13, 2021
    San Diego, California, United States


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    JOB OPPORTUNITIES

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    Sanford Research – Sioux Falls, South Dakota, United States

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    The University of Chicago – Chicago, Illinois, United States

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    University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Faculty Member – Cellular, Developmental, and Stem Cell Biology

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Research Associate – Stem Cell Differentiation and Cancer Initiation

    University of Miami – Miami, Florida, United States

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