Cord Blood News Volume 12.41 | Oct 29 2020

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    2020-10-29 | CBN 12.41


    Cord Blood News by STEMCELL Technologies
    Vol. 12.41 – 29 October, 2020
    TOP STORY

    Standardized Xeno- and Serum-Free Culture Platform Enables Large-Scale Expansion of High-Quality Mesenchymal Stem/Stromal Cells from Perinatal and Adult Tissue Sources

    The authors established a standardized culture platform using xeno- and serum-free commercial media for expansion of MSCs derived from umbilical cord, bone marrow and adipose-derived and examined their functional characteristics.
    [Cytotherapy]

    AbstractGraphical Abstract
    Learn about the applications of the CFU assay in toxicity testing from hematopoietic expert Dr. Jackie Damen.
    PUBLICATIONSRanked by the impact factor of the journal

    Physicochemical Characterization and Self-Assembly of Human Amniotic Membrane and Umbilical Cord Collagen: A Comparative Study

    Investigators extracted collagen from human amniotic membrane and umbilical cord, which are treated as medical waste and compared its physico-chemical properties.
    [International Journal of Biological Macromolecules]

    AbstractGraphical Abstract

    Enhancing the Therapeutic Potential of CCL2-Overexpressing Mesenchymal Stem Cells in Acute Stroke

    After C–C motif chemokine ligand 2 (CCL2)-overexpressing human umbilical cord (hUC)-derived MSCs were intravenously transplanted with mannitol in rats with middle cerebral arterial occlusion, scientists compared the differences between four different treatment groups: mannitol + CCL2-overexpressing hUC-MSCs, mannitol + naïve hUC-MSCs, mannitol only, and control.
    [International Journal of Molecular Sciences]

    Full Article

    Human Hematopoietic Stem, Progenitor, and Immune Cells Respond Ex Vivo to SARS-CoV-2 Spike Protein

    Investigators examined the expression of ACE2, to which SARS-CoV-2 Spike protein binds to facilitate viral entry, in cord blood derived hematopoietic stem cells/hematopoietic progenitor cells and in peripheral blood derived immune cell subtypes.
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract

    Enumerating Regulatory T Cells in Cryopreserved Umbilical Cord Blood Samples Using FOXP3 Methylation Specific Quantitative PC

    To establish the most robust and efficient way to measure the Treg content of previously cryopreserved cord blood units, researchers compared the enumeration of Treg and CD3+ cells using flow cytometry and an epigenetic, DNA-based methodology.
    [PLoS One]

    Full Article

    Y-27632 Promotes the Healing of Corneal Endothelial Wounds Using Endothelial Progenitor Cells Derived from Umbilical Cord Blood

    Researchers investigated the proliferation of umbilical cord blood–derived endothelial progenitor cells and the differentiation efficiency toward corneal endothelial cell-like cells induced by rho-associated protein kinase inhibitor Y-27632 and to determine the most effective strategy for repairing corneal endothelium injuries in rabbits.
    [Cornea]

    Abstract

    Visit the Hematopoiesis Resource Center for videos, tips, and protocols to help with your research questions.
    REVIEWS

    Differentiation Induction of Human Stem Cells for Corneal Epithelial Regeneration

    Stem cells can be induced to differentiate to corneal epithelial cells and used in treatment in corneal epithelium deficiency. Multipotent stem cells (MSCs) and pluripotent stem cells (ESCs and iPSCs) are promising cells to address the problem. Various protocols have been developed to induce differentiation of the stem cells into corneal epithelial cells.
    [International Journal of Molecular Sciences]

    Abstract
    INDUSTRY AND POLICY NEWS

    Bayer Acquires Asklepios BioPharmaceutical to Broaden Innovation Base in Cell and Gene Therapy

    Bayer AG announced the acquisition of Asklepios BioPharmaceutical, Inc., a US-headquartered biopharmaceutical company specialized in the research, development and manufacturing of gene therapies across different therapeutic areas.
    [Bayer AG]

    Press Release
    FEATURED EVENT

    Gordon Research Conferences: Stem Cells and Cancer

    May 16 – May 21, 2021
    Lucca, Italy

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    JOB OPPORTUNITIES

    Postdoctoral Researcher – Stem Cells / MSCs

    National University of Ireland Galway – Galway, Ireland

    Computational Biologist – Transcription and Chromatin Factors in Hematopoiesis

    University of Navarra – Pamplona, Spain

    Staff Scientist – Heart Disease Molecular Mechanisms

    Sanford Research – Sioux Falls, South Dakota, United States

    Postdoctoral Scientists – Stem Cell Factors in Epithelial Cancers

    The University of Chicago – Chicago, Illinois, United States

    Faculty Position – Stem Cell Biology

    University of Texas Southwestern Medical Center – Dallas, Texas, United States

    > See All Jobs

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