Cord Blood News Volume 12.42 | Nov 5 2020

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    2020-11-05 | CBN 12.42


    Cord Blood News by STEMCELL Technologies
    Vol. 12.42 – 5 November, 2020
    TOP STORY

    Mesenchymal
    Stem Cell-Derived Exosomal MicroRNA-139-5p Restrains Tumorigenesis in Bladder Cancer by Targeting PRC1

    Bladder cancer cells were co-cultured with exosomes isolated from human umbilical cord MSCs over-expressing miR-139-5p. The intercellular transfer of miR-139-5p along with in vitro and in vivo functions was determined using gain- and loss-of-function approaches.
    [Oncogene]

    Abstract

    Learn about the applications of the CFU assay in toxicity testing from hematopoietic expert Dr. Jackie Damen.
    PUBLICATIONSRanked by the impact factor of the journal

    miRNA-126-3p
    Carried by Human Umbilical Cord Mesenchymal Stem Cell Enhances Endothelial Function through Exosome-Mediated Mechanisms In Vitro and Attenuates Vein Graft Neointimal Formation In Vivo

    Human umbilical cord MSCs and human umbilical vein endothelial cells were isolated from human umbilical cords and characterized by a series of experiments. Lentivirus vector encoding miRNA-126-3p was transfected into hucMSCs and verified by PCR.
    [Stem Cell Research & Therapy]

    Full Article

    Human
    Umbilical Cord Mesenchymal Stem Cells Restore the Ovarian Metabolome and Rescue Premature Ovarian Insufficiency in Mice

    Investigators revealed remarkable changes of multiple metabolites, especially lipids, in ovarian tissues after premature ovarian insufficiency (POI) generation. Following the transplantation of clinical-grade human umbilical cord MSCs, POI mice exhibited significant improvements in body weight, sex hormone levels, estrous cycles, and reproductive capacity.
    [Stem Cell Research & Therapy]

    Full Article

    Clinical
    Analysis of Human Umbilical Cord Mesenchymal Stem Cell Allotransplantation in Patients with Premature Ovarian Insufficiency

    61 patients diagnosed with premature ovarian insufficiency participated in this study. Umbilical cord-MSCs were isolated and cultured according to GMP standards, and then transplanted to the patients’ ovary by orthotopic injection under the guidance of vaginal ultrasound.
    [Cell Proliferation]

    Full Article

    Umbilical
    Cord Tissue Is a Robust Source for Mesenchymal Stem Cells with Enhanced Myogenic Differentiation Potential Compared to Cord Blood

    Researchers found that CD45−CD34− MSCs obtained from umbilical cord tissue and blood of term births displayed differences in the combinatorial expression of key MSC markers CD105 and CD90.
    [Scientific Reports]

    Full Article

    Upregulation
    of C-Reactive Protein by Placenta-Derived Mesenchymal Stem Cells Promotes Angiogenesis in a Rat Model with Cirrhotic Liver

    The expression of C-reactive protein in CCl4-injured rat livers was detected using qRT-PCR and Western blotting after transplantation of placenta-derived MSCs into rats.
    [International Journal of Stem Cells]

    Abstract

    Early
    and Sustained Improvements in Motor Function in Rats after Infusion of Allogeneic Umbilical Cord-Derived Mesenchymal Stem Cells following Spinal Cord Injury

    The authors indicated that intravenous injection of allogenic umbilical cord-MSCs without immunosuppression exerted beneficial effects in subacute spinal cord injury (SCI) and thus could be a useful therapy to improve the functional capacity among patients with SCI.
    [Spinal Cord]

    Abstract

    The StemSpanâ„¢ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    REVIEWS

    Mesenchymal
    Stem Cell Markers in Periodontal Tissues and Periapical Lesions

    Investigators explore the literature on markers able to identify MSCs as well as the presence of these cells in the healthy periodontal ligament and chronic periapical lesions, highlighting their role in regenerative medicine and implications in the progression of these lesions.
    [Acta Histochemica]

    Abstract
    INDUSTRY AND POLICY NEWS

    Bone
    Therapeutics and Catalent Sign Agreements to Streamline Production of the Allogeneic Cell Therapy Product, ALLOB

    Bone Therapeutics and Catalent Pharma Solutions, Inc. announced the signing of share purchase and supply agreements to streamline and economize the manufacturing operations of ALLOB, Bone Therapeutics’ allogeneic cell therapy product and will enable Bone Therapeutics to focus its strategy on the development of products from its differentiated MSC platform of cell and gene therapeutic targets for orthopedics and other indications.
    [Bone Therapeutics]

    Press Release

    IMAC Holdings, Inc. Announces Opening Enrollment in Its Phase I Clinical Study of Umbilical Cord-Derived Mesenchymal Stem Cells for the Treatment of Bradykinesia Due to Parkinson’s Disease

    IMAC Holdings, Inc. announced it is opening enrollment in its Phase I clinical trial for its investigational compound utilizing umbilical cord-derived allogenic MSCs for the treatment of bradykinesia, or the gradual slowing and loss of spontaneous body movement, due to Parkinson’s disease.
    [IMAC Holdings, Inc. (GlobeNewswire, Inc.)]

    Press Release

    FEATURED EVENT

    Neurodegenerative Diseases: Biology & Therapeutics

    December 2 – December 4
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Lab Supervisor – Forensic Toxicology

    United States Drug Testing Laboratories, Inc. – Des Plaines, Illinois, United States

    Postdoctoral Researcher – Stem Cells / MSCs

    National University of Ireland Galway – Galway, Ireland

    Computational
    Biologist – Transcription and Chromatin Factors in Hematopoiesis

    University of Navarra – Pamplona, Spain

    Staff
    Scientist – Heart Disease Molecular Mechanisms

    Sanford Research – Sioux Falls, South Dakota, United States

    Postdoctoral
    Scientists – Stem Cell Factors in Epithelial Cancers

    The University of Chicago – Chicago, Illinois, United States

    > See All Jobs

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