Cord Blood News Volume 12.43 | Nov 19 2020

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    2020-11-19 | CBN 12.43


    Cord Blood News by STEMCELL Technologies
    Vol. 12.43 – 19 November, 2020
    TOP STORY

    Articular
    Chondrocyte-Derived Extracellular Vesicles Promote Cartilage Differentiation of Human Umbilical Cord Mesenchymal Stem Cells by Activation of Autophagy

    Scientists successfully isolated chondrogenic-derived from human multi-finger cartilage and found that human chondrogenic-derived extracellular vesicles efficiently promoted the proliferation and chondrogenic differentiation of human umbilical cord MSCs, evidenced by highly expressed aggrecan, COL2A, and SOX-9.
    [Journal of Nanobiotechnology]

    Full ArticleGraphical Abstract

    The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    PUBLICATIONSRanked by the impact factor of the journal

    Functionally
    Enhanced Placenta-Derived Mesenchymal Stem Cells Inhibit Adipogenesis in Orbital Fibroblasts with Graves’ Ophthalmopathy

    Placenta-derived-MSCs isolated from human placenta were transfected with the phosphatase of regenerating liver-1 gene using nonviral transfection method. Primary OFs were isolated from orbital adipose tissue specimens from Graves’ ophthalmopathy.
    [Stem Cell Research & Therapy]

    Full Article

    Human
    Placenta-Derived Mesenchymal Stem Cells Stimulate Ovarian Function via miR-145 and Bone Morphogenetic Protein Signaling in Aged Rats

    Acclimatized 52-week-old female Sprague-Dawley rats were randomly divided into four groups: single human placenta derived (hPD)-MSC therapy, multiple hPD-MSC therapy, control, and non-treated groups. hPD-MSC therapy was conducted by tail vein injection into aged rats.
    [Stem Cell Research & Therapy]

    Full Article

    Human
    Mesenchymal Stromal Cells Do Not Express ACE2 and TMPRSS2 and are Not Permissive to SARS-CoV-2 Infection

    Researchers evaluated if human MSCs from both fetal and adult tissues constitutively expressed angiotensin‐converting enzyme 2 (ACE2) and type II transmembrane serine protease (TMPRSS2) and, most importantly, if they could be infected by SARS‐CoV‐2.
    [Stem Cells Translational Medicine]

    Abstract

    Sodium
    Alginate/Collagen Hydrogel Loaded with Human Umbilical Cord Mesenchymal Stem Cells Promotes Wound Healing and Skin Remodeling

    An injectable hydrogel composed of sodium alginate and collagen type I was synthesized as a tissue scaffold to improve the efficacy of stem cells in a full-thickness excision wound model.
    [Cell and Tissue Research]

    Abstract

    Regeneration
    of a Full-Thickness Defect in Rotator Cuff Tendon with Umbilical Cord-Derived Mesenchymal Stem Cells in a Rat Model

    Scientists injected either umbilical cord MSCs or saline to the full-thickness rotator cuff defect and investigated macroscopic, histological and biomechanical results and cell trafficking.
    [PLoS One]

    Full Article

    Evaluating
    the Effect of Transplanting Umbilical Cord Matrix Stem Cells on Ischemic Tolerance in an Animal Model of Stroke

    The impact of transplanting umbilical cord stem cells on injuries resulting from ischemia was investigated. The male rats were categorized into three major groups. Using stereotaxic surgery, stem cells were injected to the right striatum of the brain.
    [Neurological Research]

    Abstract

    Request your free copy of the 'Bone Marrow Niches and HSC Fates' Wallchart
    REVIEWS

    Differentiation
    of Human Induced Pluripotent Stem Cells into Erythroid Cells

    Human pluripotent stem cells (PSCs) are a promising alternative to umbilical cord blood- or bone marrow-derived erytrocytes, providing an unlimited source of cells. Human PSCs, including embryonic stem cells and induced pluripotent stem cells, are self-renewing progenitors that can be differentiated to lineages of ectoderm, mesoderm, and endoderm.
    [Stem Cell Research & Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Texas
    Heart to Participate in Global Stem Cell Study to Treat ARDS due to COVID-19

    The Texas Heart Institute has been selected as one of up to 60 sites in the world to participate in an international investigative study seeking to aid COVID-19 patients who develop acute respiratory distress syndrome (ARDS).
    [Texas Heart Institute]

    Press Release
    FEATURED EVENT

    International
    Conference on Stem Cell Science and Regenerative Medicine

    November 1 – November 2, 2021
    San Fransico, California, United States


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    JOB OPPORTUNITIES


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    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

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    New York Blood Center – New York, New York, United States

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    Stanford University – Stanford, California, United States

    Lab Supervisor – Forensic Toxicology

    United States Drug Testing Laboratories, Inc. – Des Plaines, Illinois, United States

    Staff
    Scientist – Heart Disease Molecular Mechanisms

    Sanford Research – Sioux Falls, South Dakota, United States

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