Cord Blood News Volume 13.02 | Jan 21 2021

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    2020-01-21 | CBN 10.02


    Cord Blood News by STEMCELL Technologies
    Vol. 10.02 – 21 January, 2021
    TOP STORY

    Successful
    Gene Therapy of Diamond-Blackfan Anemia in a Mouse Model and Human CD34+ Cord Blood Hematopoietic Stem Cells Using a Clinically Applicable Lentiviral Vector

    Researchers observed that transduced ribosomal protein S19 (Rps19)-deficient bone marrow cells could reconstitute mice longterm and rescue the bone marrow failure and severe anemia observed in Rps19-deficient mice, with a low risk of mutagenesis and a highly polyclonal insertion site pattern.
    [Haematologica]

    Abstract

    Learn about the applications of the CFU assay in toxicity testing from hematopoietic expert Dr. Jackie Damen.
    PUBLICATIONSRanked by the impact factor of the journal

    Human
    Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Ameliorate Airway Inflammation in a Rat Model of Chronic Obstructive Pulmonary Disease (COPD)

    The authors assessed the potential anti-inflammatory effects of human umbilical cord MSC-derived extracellular vesicles in a rat model of chronic obstructive pulmonary disease.
    [Stem Cell Research & Therapy]

    Full Article

    Comparative
    Proteomic Analysis of the Mesenchymal Stem Cells Secretome from Adipose, Bone Marrow, Placenta and Wharton’s Jelly

    Scientists characterized the protein secretome of adipose, bone marrow, placenta, and Wharton’s jelly-derived human MSCs by using conditioned media and analyzing the secretome by mass spectrometry and follow-up bioinformatics.
    [International Journal of Molecular Sciences]

    Full Article

    High
    Integrity and Fidelity of Long-Term Cryopreserved Umbilical Cord Blood for Transplantation

    Researchers demonstrated the recovery of viable total nucleated cells and CD34+ cells, as well as the mononuclear cell viability in 20-year-old cryopreserved cord blood (CB) units in a CB bank.
    [Journal of Clinical Medicine]

    Full Article

    Hypoxic
    Preconditioning of Human Umbilical Cord Mesenchymal Stem Cells Is an Effective Strategy for Treating Acute Lung Injury

    When human umbilical cord MSCs were transplanted directly, only a minority of cells migrated toward damaged tissues. Their maintenance time was short, leading to unsatisfactory therapeutic results.
    [Stem Cells and Development]

    Abstract

    Supervised
    Machine Learning for Automated Classification of Human Wharton’s Jelly Cells and Mechanosensory Hair Cells

    Images from previous work, where human Wharton’s Jelly cells were differentiated into mechanosensory hair cell-like cells, were examined. Various cell features were extracted from these images, and those which were pertinent to classification were identified.
    [PLoS One]

    Full Article

    Explore scientific events this January with the Science Events Calendar.
    REVIEWS

    Amniotic
    Fluid Stem Cells as a Novel Strategy for the Treatment of Fetal and Neonatal Neurological Diseases

    Investigators outline the results of preclinical research on fetal stem cell therapy, mainly involving human amniotic fluid stem cells, in the context of perinatal neurological diseases.
    [Placenta]

    Abstract
    INDUSTRY AND POLICY NEWS

    Bone Therapeutics and Rigenerand Sign Partnership For Cell Therapy Process Development

    Bone Therapeutics and Rigenerand SRL, the biotech company that both develops and manufactures medicinal products for cell therapy applications, primarily for regenerative medicine and oncology, announced the signing of a first agreement for a process development partnership.
    [Bone Therapeutics]

    Press Release

    FEATURED EVENT

    Hematopoietic Stem Cells: Biology, Disease, and Therapy

    March 9, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Pediatric Myeloid Tumors

    St. Jude Children’s Hospital – Memphis, Tennessee, United States

    Scientific
    Communities & Communications Specialist

    STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada

    Research Assistant – Cord Blood and Stem Cell Products

    University of Colorado – Aurora, Colorado, United States

    Senior
    Manager – FACS-Based Characterization

    Fondazione Human Technopole – Milan, Italy

    Postdoctoral Researcher – Mitochondria and Hematopoietic Stem Cell Biology

    Columbia University Medical Center – New York, New York, United States

    > See All Jobs

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