Cord Blood News Volume 13.04 | Feb 4 2021

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    2021-01-04 | CBN 12.04


    Cord Blood News by STEMCELL Technologies
    Vol. 12.04 – 4 February, 2021
    TOP STORY

    FOXO1 Constrains Activation and Regulates Senescence in CD8 T Cells

    In naive cells, the deletion of Foxo1 following thymic development resulted in the increased expression of multiple AP-1 family members, rendering T cells less able to respond to antigenic challenge.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Kevin Shoulars found a faster, more reproducible way to assess the potency of core blood units for transplant. Watch the webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Transcriptional and Functional Characterization of Neonatal Circulating ILCs

    Researchers analyzed the transcriptomes and effector functions of cord blood innate lymphoid cells (ILCs). By RNAseq analysis, all ILC subsets could be clearly distinguished from each other.
    [Stem Cells Translational Medicine]

    Full Article

    Intravenous Allogeneic Umbilical Cord Blood–Derived Mesenchymal Stem Cell Therapy in Recessive Dystrophic Epidermolysis Bullosa Patients

    In a Phase I/IIa trial, scientists evaluated the safety and possible clinical efficacy of intravenous infusion of allogeneic human umbilical cord blood–derived mesenchymal stem cells in patients with recessive dystrophic epidermolysis bullosa.
    [JCI Insight]

    Full Article

    The Delivery of Hsa-miR-11401 by Extracellular Vesicles Can Relieve Doxorubicin-Induced Mesenchymal Stem Cell Apoptosis

    Doxorubicin, a commonly used chemotherapy drug, was used to treat human umbilical cord-derived MSCs for six hours as an in vitro cell model of chemotherapy-induced damage.
    [Stem Cell Research & Therapy]

    Full Article

    Allogenic Umbilical Cord Blood-Derived Mesenchymal Stromal Cell Implantation Was Superior to Bone Marrow Aspirate Concentrate Augmentation for Cartilage Regeneration despite Similar Clinical Outcomes

    Investigators compared clinical and second-look arthroscopic outcomes between bone marrow aspirate concentrate augmentation and human umbilical cord blood-derived mesenchymal stromal cell implantation in high tibial osteotomy for medial compartmental knee osteoarthritis.
    [Knee Surgery, Sports Traumatology, Arthroscopy]

    Abstract

    Mesenchymal Stem Cells Derived from Wharton’s Jelly Can Differentiate into Schwann Cell-Like Cells and Promote Peripheral Nerve Regeneration in Acellular Nerve Grafts

    The differentiation of Wharton jelly (WJ)-MSCs into Schwann cell-like cells was determined by analyzing Schwann cell-specific markers. The secretion of neurotrophic factors was assessed by the Neuro Discovery antibody array.
    [Tissue Engineering and Regenerative Medicine]

    Abstract
    Explore scientific events this February with the Science Events Calendar.
    REVIEWS

    Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells

    The authors describe the biological characteristics and advantages of human amnion-derived stem cells, especially for their high pluripotency and immunomodulatory effects.
    [International Journal of Molecular Sciences]

    Full Article
    INDUSTRY AND POLICY NEWS

    Fourth Patient Also Released from Hospital following Third Infusion of Stem Cells

    Sorrento Therapeutics, Inc.  announced additional positive results from its Phase Ib study of human allogeneic adipose-derived mesenchymal stem cells for patients suffering from COVID-19-induced acute respiratory distress or acute respiratory distress syndrome.
    [Sorrento Therapeutics, Inc. ]

    Press Release
    FEATURED EVENT

    The European Society for Blood and Marrow Transplantation

    March 14 – 17, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Biobank Administrator – Hematopoietic Samples

    University of Oxford – Oxford, England, United Kingdom

    Faculty Position – Department of Hematology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Associate – Epigenetic Mechanisms Governing Hematopoietic Stem Cell Lineage Commitment

    The Jackson Laboratory – Bar Harbor, Maine, United States

    Training Fellowships – Glycosciences

    Blood Research Institute – Milwaukee, Wisconsin, United States

    Research Associate – Pediatric Myeloid Tumors

    St. Jude Children’s Hospital – Memphis, Tennessee, United States

    > See All Jobs

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