| Vol. 12.04 – 4 February, 2021 |
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| In naive cells, the deletion of Foxo1 following thymic development resulted in the increased expression of multiple AP-1 family members, rendering T cells less able to respond to antigenic challenge. [Cell Reports] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers analyzed the transcriptomes and effector functions of cord blood innate lymphoid cells (ILCs). By RNAseq analysis, all ILC subsets could be clearly distinguished from each other. [Stem Cells Translational Medicine] |
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| In a Phase I/IIa trial, scientists evaluated the safety and possible clinical efficacy of intravenous infusion of allogeneic human umbilical cord blood–derived mesenchymal stem cells in patients with recessive dystrophic epidermolysis bullosa. [JCI Insight] |
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| Doxorubicin, a commonly used chemotherapy drug, was used to treat human umbilical cord-derived MSCs for six hours as an in vitro cell model of chemotherapy-induced damage. [Stem Cell Research & Therapy] |
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| Investigators compared clinical and second-look arthroscopic outcomes between bone marrow aspirate concentrate augmentation and human umbilical cord blood-derived mesenchymal stromal cell implantation in high tibial osteotomy for medial compartmental knee osteoarthritis. [Knee Surgery, Sports Traumatology, Arthroscopy] |
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| The differentiation of Wharton jelly (WJ)-MSCs into Schwann cell-like cells was determined by analyzing Schwann cell-specific markers. The secretion of neurotrophic factors was assessed by the Neuro Discovery antibody array. [Tissue Engineering and Regenerative Medicine] |
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| The authors describe the biological characteristics and advantages of human amnion-derived stem cells, especially for their high pluripotency and immunomodulatory effects. [International Journal of Molecular Sciences] |
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| Sorrento Therapeutics, Inc.  announced additional positive results from its Phase Ib study of human allogeneic adipose-derived mesenchymal stem cells for patients suffering from COVID-19-induced acute respiratory distress or acute respiratory distress syndrome. [Sorrento Therapeutics, Inc. ] |
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| March 14 – 17, 2021 Virtual |
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| University of Oxford – Oxford, England, United Kingdom |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| The Jackson Laboratory – Bar Harbor, Maine, United States |
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| Blood Research Institute – Milwaukee, Wisconsin, United States |
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| St. Jude Children’s Hospital – Memphis, Tennessee, United States |
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