Cord Blood News Volume 13.05 | Feb 11 2021

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    2021-02-11 | CBN 12.05


    Cord Blood News by STEMCELL Technologies
    Vol. 12.05 – 11 February, 2021
    TOP STORY

    Stem Cell Secreted Factor Therapy Regenerates the Ovarian Niche and Rescues Follicles

    The effects of human plasma enriched in bone marrow stem cell soluble factors by granulocyte colony stimulating factor mobilization, umbilical cord blood plasma, and their activated forms on ovarian niche, follicle development and breeding performance were assessed in mouse models of chemotherapy-induced ovarian damage.
    [American Journal of Obstetrics and Gynecology]

    Abstract
    How to prioritize and manage your research projects
    PUBLICATIONSRanked by the impact factor of the journal

    Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying miRNA as a Potential Multi Target Therapy to COVID-19: an In Silico Analysis

    Scientists investigated whether the MSC-extracellular vesicles miRNA cargo had the capacity to modulate the exacerbated cytokines, cell death and coagulation disturbs present in severe COVID-19.
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract

    RXR Negatively Regulates Ex Vivo Expansion of Human Cord Blood Hematopoietic Stem and Progenitor Cells

    The authors report that retinoid X receptor (RXR) activity was of significance for cord blood (CB) hematopoietic stem cells (HSC) ex vivo expansion. RXR antagonist HX531 significantly promoted ex vivo expansion of CB HSCs and progenitor cells.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    Mesenchymal Stem Cells Derived from Perinatal Tissues for Treatment of Critically Ill COVID-19-Induced ARDS Patients: A Case Series

    In this Phase I clinical trial, researchers present the safety, feasibility, and tolerability of the multiple infusions of high dose MSCs, which originated from the placenta and umbilical cord, in critically ill COVID-19-induced acute respiratory distress syndrome (ARDS) patients.
    [Stem Cell Research & Therapy]

    Full Article

    Chondrogenesis of Human Amniotic Fluid Stem Cells in Chitosan-Xanthan Scaffold for Cartilage Tissue Engineering

    Scientists investigated the chondrogenic potential of amniotic fluid stem cells in a micromass system under insulin-like growth factor 1 stimuli, as well as to look at their potential to differentiate directly when cultured in a porous chitosan-xanthan scaffold.
    [Scientific Reports]

    Full Article

    Umbilical Cord Derived Mesenchymal Stromal Cells in Microcarrier Based Industrial Scale Sustain the Immune Regulatory Functions

    Researchers optimized the culture conditions for umbilical cord‐MSCs by using a good manufacturing practice‐compatible serum‐free medium, developed in‐house, and a small‐scale bioreactor, which was later scaled up to 500 mL.
    [Biotechnology Journal]

    Abstract

    Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomal MicroRNA-18b-3p Inhibits the Occurrence of Preeclampsia by Targeting LEP

    The authors investigated the effect of exosomes and miR-18b-3p/leptin (LEP) on occurrence of preeclampsia. The morphology of the human umbilical cord (hUC) MSCs and hucMSC-exosomes was identified.
    [Nanoscale Research Letters]

    Full Article

    First Trimester Placental Mesenchymal Stem Cells Improve Cardiac Function of Rat after Myocardial Infarction via Enhanced Neovascularization

    First-trimester placental chorion mesenchymal stem cells (CMSCs) and third-trimester CMSCs were isolated and characterized, and then they were subjected to in vitro endothelial cell differentiation induction and tube formation to evaluate angiogenic ability.
    [Heliyon]

    Full Article
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    REVIEWS

    Human Amniotic Membrane as a Delivery Vehicle for Stem Cell-Based Therapies

    Investigators overview the recent progress, challenges, and future perspectives in the use of amniotic membrane as a delivery platform for stem cells.
    [Life Sciences]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    AbbVie and Caribou Biosciences Announce Collaboration and License Agreement for CAR-T Cell Products

    AbbVie and Caribou Biosciences, Inc. announced that they have entered into a collaboration and license agreement for the research and development of chimeric antigen receptor (CAR)-T cell therapeutics.
    [Caribou Biosciences, Inc.]

    Press Release
    FEATURED EVENT

    Wisconsin Stem Cell Symposium: The Single Cell Revolution in Stem Cells

    April 14, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant – Immune Modulation of MSCs

    National University of Ireland Galway – Galway, Ireland

    Biobank Administrator – Hematopoietic Samples

    University of Oxford – Oxford, England, United Kingdom

    Faculty Position – Department of Hematology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Associate – Epigenetic Mechanisms Governing Hematopoietic Stem Cell Lineage Commitment

    The Jackson Laboratory – Bar Harbor, Maine, United States

    Training Fellowships – Glycosciences

    Blood Research Institute – Milwaukee, Wisconsin, United States

    > See All Jobs

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