| Vol. 12.06 – 18 February, 2021 |
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| Human cord blood-derived megakaryocytes were treated with antisense oligonucleotides (ASOs) to study effects on proplatelet production. Platelet activation and platelet-leukocyte aggregates were analyzed in ASO-treated blood from healthy human volunteers. [Haematologica] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Burn-derived MSCs- and umbilical cord-MSCs were compared using immunophenotyping, multi-lineage differentiation, seahorse analysis for glycolytic and mitochondrial function, immune surface markers, and cell secretion profile assays. [Stem Cell Research & Therapy] |
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| Investigators designed and performed this study to determine whether exosomes attenuate the lesion size of spinal cord injury by ameliorating neuronal injury induced by a secondary inflammatory storm and promoting neurite outgrowth. [Stem Cell Research & Therapy] |
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| Researchers examined the anti-oxidative potential of human amniotic membrane-derived MSC-conditioned medium treatment during in vitro culture on mouse preimplantation embryo development and antioxidant gene expression in the forkhead box O pathway. [Antioxidants] |
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| Investigators generated a human induced pluripotent stem cell line from a patient’s amniotic fluid cells with a 18 Mb duplication in 8p23.3p22, which could serve as useful tools for studying duplication of chromosome 8p syndrome. [Stem Cell Research] |
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| Human umbilical cord (UC) MSCs were used to deliver reovirus using in vitro and in vivo models. Human UC-MSCs were successfully loaded with reovirus, without impairing biological function [International Immunopharmacology] |
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| Scientists detected the levels of both PD-1 and PD-L1 as resistance to iRGD-antiCD3 treatment. Using cord blood-derived T cells, they assessed the activation and effects of iRGD-antiCD3 combined with PD-1 as evidenced by activation markers, Th1/Th2-cytokines, and killing capability against tumor cells in vitro. [Oncotargets and Therapy] |
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| The impact of adenosine on peripheral and cord blood mononuclear cells was analyzed by quantification of ectonucleotidases and adenosine receptor expression. [Pediatric Research] |
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| There are conflicting opinions about the role of human amniotic membrane/fluid MSCs in cancer, as some studies demonstrating the anti-cancer effects of these cells and others suggesting their progressive effects on cancer. [Stem Cell Research & Therapy] |
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| Mesoblast Limited announced results from the Phase III randomized controlled trial of its allogeneic mesenchymal precursor cell therapy rexlemestrocel-L in 404 enrolled patients with chronic low back pain due to degenerative disc disease refractory to conventional treatments. [Mesoblast, Ltd.] |
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| Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| The Jackson Laboratory – Bar Harbor, Maine, United States |
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| Blood Research Institute – Milwaukee, Wisconsin, United States |
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