 | | Vol. 12.06 – 25 February, 2021 |
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| Investigators describe an optimized and upscalable process for the isolation of extracellular vescicles smaller than 200nm, secreted by umbilical cord blood mononuclear cells under ischemic conditions and propose quality control thresholds for the isolated vesicles, based on the thorough characterization of their protein, lipid and RNA content.
[Stem Cells Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors used rat liver-derived hepatocytes injured by CCl4 treatment in co-culture system with Vitamin E pretreated-Wharton’s jelly-derived MSCs (WJMSCs) to evaluate the hepatoprotective effect of vitamin E-WJMSCs.
[Biochemical Pharmacology] |
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| Exosomes were isolated from MSCs using ultracentrifugation, and further characterized by the nanoparticle tracking analyzer and flow cytometry. RNA sequencing, Western Blot, in vitro cell proliferation, in vivo pro-angiogenesis, as well as ischemic repairment of diabetic foot through rat model were performed to evaluate exosome physiological functions.
[Stem Cell Research] |
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| Scientists investigated the effects of high glucose on the innate immunity of podocytes and diabetic nephropathy mice via Toll like receptor (TLR) signaling, and explored the protective effects of human umbilical cord-MSCs on this process.
[Diabetes Research and Clinical Practice] |
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| To better understand the effects of preeclampsia on angio-vasculogenesis and inflammatory networks in the fetus and to identify their biological signatures, researchers investigated the quantitative and functional characteristics of cord blood-derived mononuclear cells (MNCs) and CD31-positive MNCs.
[Scientific Reports] |
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| Researchers isolated exosomes derived from umbilical cord MSCs grown in a 3D culture system and explored their ability to modulate the photo-aging of HaCaT keratinocytes.
[Rejuvenation Research] |
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| MiR-6785-5p and inhibin subunit beta A (INHBA) expression in gastric cancer (GC) tissues and cells were determined. GC cells were transfected with the vectors that altered miR-6785-5p or INHBA expression.
[Life Sciences] |
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| The effects of human Wharton’s jelly-derived MSCs on hyperalgesia, anxiety deficiency and Pallidal local electroencephalogram impairment, alone and combined with L-dopa, were examined in a rat model of Parkinson’s disease.
[Journal of Chemical Neuroanatomy] |
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| Scientists discuss the major challenges of MSC therapies in clinical application, the factors impacting the diversity of MSCs, the potential approaches that modify MSC products with the highest therapeutic potential, and finally the usage of MSCs for COVID-19 pandemic disease.
[Journal of Hematology & Oncology] |
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| Mesoblast Limited has treated the first two children with their MSC product candidate remestemcel-L for life-threatening multisystem inflammatory syndrome (MIS-C) associated with COVID-19.MIS-C, a potentially life-threatening inflammatory condition which involves multiple critical organs and their vasculature, is associated with prior rather than active COVID-19 infection.
[Mesoblast, Ltd.] |
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| | CyberCoders – San Diego, California, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | The Jackson Laboratory – Bar Harbor, Maine, United States |
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