Cord Blood News Volume 13.08 | Mar 4 2021

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    Justin.choi
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    2021-03-04 | CBN 12.08


    Cord Blood News by STEMCELL Technologies
    Vol. 12.08 – 4 March, 2021
    TOP STORY

    Macrophage Migration Inhibitory Factor Facilitates the Therapeutic Efficacy of Mesenchymal Stem Cells Derived Exosomes in Acute Myocardial Infarction through Upregulating miR-133a-3p

    Exosomes isolated from umbilical cord MSCs (ucMSC), MIF engineered ucMSCs and MIF downregulated ucMSCs were used to investigate cellular protective function in human umbilical vein endothelial cells and H9C2 cardiomyocytes under hypoxia and serum deprivation and infarcted hearts in rats.
    [Journal of Nanobiotechnology]

    Full Article
    Explore scientific events this March with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    Plasma and Red Blood Cells Distribution of Total Mercury, Inorganic Mercury, and Selenium in Maternal and Cord Blood from a Group of Japanese Women

    Investigators compared the characteristic profiles of total mercury, inorganic mercury, MeHg, and selenium in plasma and red blood cells between maternal and cord blood at parturition collected from a group of Japanese women.
    [Environmental Research]

    Abstract

    Allogenic Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Is More Effective than Bone Marrow Aspiration Concentrate for Cartilage Regeneration after High Tibial Osteotomy in Medial Unicompartmental Osteoarthritis of Knee

    The authors compared the outcome of cartilage regeneration between bone marrow aspirate concentrate augmentation and allogeneic human umbilical cord blood-derived MSCs (hUCB-MSCs) transplantation in high tibial osteotomy with microfracture for medial unicompartmental osteoarthritis of knee in the young and active patients.
    [Anthroscopy]

    Abstract

    DNA Damage Response and Apoptosis Induced by Hyperthermia in Human Umbilical Cord Blood Lymphocytes

    Researchers investigated DNA double-strand break and apoptosis induced by hyperthermia (HT). Umbilical cord blood lymphocytes were subjected to HT at 43 °C.
    [Toxicology in Vitro]

    Abstract

    Single Cord Blood Transplantation for Acute Myeloid Leukemia Patients Aged 60 Years or Older: A Retrospective Study in Japan

    Investigators compared the characteristic profiles of total mercury, inorganic mercury, MeHg, and selenium in plasma and red blood cells between maternal and cord blood at parturition collected from a group of Japanese women.
    [Annals of Hematology]

    Abstract

    Blood Type Change Identifies Late Dominance Reversal of Chimerism after Double Umbilical Cord Blood Transplantation with Review of the Literature

    PCR‐based short tandem repeat assays were performed on the peripheral blood and bone marrow samples. The white blood cell populations from the peripheral blood were manipulated for testing to create subpopulations enriched for CD3, CD33, and CD56.
    [Transfusion]

    Abstract

    Effect of Methotrexate Dose in Graft-versus-Host Disease Prophylaxis after Single-Unit Cord Blood Transplantation in Adult Acute Myeloid Leukemia

    The authors investigated the association between methotrexate dosage and engraftment, graft-versus-host disease (GvHD) incidence, and survival in umbilical cord blood transplantation, and compared transplant outcomes after umbilical cord blood transplantation with various GvHD prophylaxis regimens, using registry data with additional data collection.
    [International Journal of Hematology]

    Abstract
    The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    REVIEWS

    Stem Cells and COVID-19: Are the Human Amniotic Cells a New Hope for Therapies against the SARS-CoV-2 Virus?

    Scientists discuss the human amniotic membrane cells use in patients who suffer from immune/inflammatory lung diseases and hypothesize their possible use as a successful treatment against COVID-19.
    [Stem Cell Research & Therapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    IMAC Holdings, Inc. Announces Completion of First Cohort of its Phase I Clinical Study of Umbilical Cord-Derived Mesenchymal Stem Cells for the Treatment of Bradykinesia Due to Parkinson’s Disease

    IMAC Holdings, Inc. announced it has completed the first cohort of its Phase I clinical trial for its investigational compound utilizing umbilical cord-derived allogenic mesenchymal stem cells for the treatment of bradykinesia due to Parkinson’s disease.
    [IMAC Holdings, Inc.]

    Press Release

    New Preclinical Study to Investigate the High Potency of Cymerus™ MSCs

    Cynata Therapeutics Limited announced the initiation of a new study to investigate in a pre-clinical model of lung disease the potential molecular mechanisms involved in the observed high potency of Cynata’s proprietary Cymerus™ mesenchymal stem cells.
    [Cynata Therapeutics Limited (GlobeNewswire, Inc.)]

    Press Release
    FEATURED EVENT

    3D Cell Culture 2021: Models, Applications & Translation

    May 5 – 7, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Associate Researcher – Umbilical Cord Blood Therapeutics

    Cleveland Cord Blood Center – Cleveland, Ohio, United States

    Senior Scientist – Assay Development

    CyberCoders – San Diego, California, United States

    Postdoctoral Position – Hematopoietic Development

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Research Associate – Hematopoietic System Development

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Faculty Position – Department of Hematology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    > See All Jobs

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