Cord Blood News Volume 2.06 | Feb 18 2010

May 12, 2022

Cord Blood News 2.06, February 18, 2010.

In this issue: Science News | Current Publications | Industry News | Policy News | Events

Role of Chk1 in the Differentiation Program of Hematopoietic Stem Cells
Hematopoietic stem cells isolated from umbilical cord blood were treated with ionizing radiation (IR) and sensitivity and IR induced checkpoints activation were investigated. [Cell Mol Life Sci]

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SCIENCE NEWS

Biologists Image Birth of Blood-Forming Stem Cells in Embryo
Biologists have identified the specific region in vertebrates where adult blood stem cells arise during embryonic development. [Press release from EurekaAlert! discussing the online prepublication in Nature]

An Unknown Baby’s Cord Blood Saved my Life
Philip Meehan’s life was saved by a baby he will never know. [British Broadcasting Corporation Press Release]

CURRENT PUBLICATIONS

Hematopoietic Stem Cells Derive Directly from Aortic Endothelium During Development
Here researchers have used the unique strengths of the zebrafish embryo to image directly the generation of hematopoietic stem cells from the ventral wall of the dorsal aorta. [Nature]

Ras-Induced Reactive Oxygen Species Promote Growth Factor–Independent Proliferation in Human CD34⁺ Hematopoietic Progenitor Cells
Researchers examined the contribution of reactive oxygen species production to the effects of N-Ras^G12D and H-Ras^G12V on normal human CD34⁺ progenitor cells. [Blood]

CD160 Signaling Mediates PI3K-Dependent Survival and Growth Signals in Chronic Lymphocytic Leukemia
Survival and activation signals mediated by CD160 showed dose-dependent suppression by PI3K inhibitors. Thus, in vitro, chronic lymphocytic leukemia cells can use the CD160 pathway for survival and activation, mimicking CD160 signaling in normal natural killer and CD8⁺ T cells. [Blood]

Vascular Endothelial Growth Factor Stimulates Protein Kinase C(Beta)II Expression in Chronic Lymphocytic Leukemia Cells
The aim of the present work was to investigate the factors involved in stimulating PKC(beta)II expression in chronic lymphocytic leukemia cells. [Blood]

Shaping of Invariant Natural Killer T Cell Repertoire after Unrelated Cord Blood Transplantation
Researchers found that invariant natural killer T cells were reconstituted within 1 month after unrelated cord blood transplantation, at the same time as natural killer cells and before conventional T cells. [Clin Immunol]

Monitoring the International Use of Unrelated Donors for Transplantation: The World Marrow Donor Association Annual Reports
The World Marrow Donor Association Annual Reports describe the current status of the use of unrelated hematopoietic cell products worldwide. [Bone Marrow Transplant]

Association of HLA-A, -B and -DRB1 Genotype with Birth-Weight and CD34⁺ Cell Content; Analysis of Korean Newborns and Their Cord Blood
In this study, researchers assessed HLA-A, -B, -DRB1 polymorphisms, birth-weight and cord
blood CD34⁺ cell content in 1,628 full-term healthy neonates to identify the HLA alleles that are associated with fetal growth in Koreans. [Mol Hum Reprod]

Evaluations of Bioantioxidants in Cryopreservation of Umbilical Cord Blood Using Natural Cryoprotectants and Low Concentrations of Dimethylsulfoxid
Researchers assessed the ability of two bioantioxidants and two disaccharides, to enhance the cryopreservation of umbilical cord blood. [Cryobiology]

Optimization of Cryopreservation Condition for Hematopoietic Stem Cells from Umbilical Cord Blood
This study shows that the new cryo-medium and controlled-rate freezing method provide better recoveries of mononuclear cells, hematopoietic stem cells and total colony-forming units than the control cryo-medium and isopropylalcohol freezing method. [Cryobiology]

Placenta and Umbilical Cord Blood Deserve Attention
Finding of lead in umbilical cord blood immediately after the child birth is forewarning against the possible rise of the hyperkinetic syndrome. [Neuro Endocrinol Lett]

INDUSTRY NEWS

CORD:USE Cord Blood Bank Announces Partnership with Memorial Healthcare System
CORD:USE Cord Blood Bank announced that it is partnering with the Memorial Healthcare System to collect umbilical cord blood that will be placed in a global registry for patients in need of a potentially life-saving transplant. [CORD:USE Press Release]

Living Cell Technologies Awarded NZ$4.04 Million New Zealand Government Grant to Advance DIABECELL^® for Type 1 Diabetes
Cell implant company Living Cell Technologies Limited announced that it has been awarded a grant of NZ$4.04 million from the New Zealand government’s Foundation for Research Science & Technology. [Living Cell Technologies Limited Press Release]

Data Monitoring Committee Recommends Continuation of Phase III Study of StemEx^®, a Cord Blood Stem Cell Product, for Leukemia and Lymphoma
The Gamida Cell-Teva Joint Venture (JV) announced that the Data Monitoring Committee has independently reviewed preliminary data from the pivotal registration, Phase III clinical trial of StemEx and has recommended that the JV continue to enroll patients in this study. [Gamida Cell Ltd. Press Release]

Idant Laboratories Signs a Corporate Blood Banking Contract with Rotenberg, Meril, Solomon, Bertiger & Guttilla for Individuals to Store Their Own Frozen Blood for Up to 10 Years
Idant Laboratories announced that it received a blood banking contract from Rotenberg, Meril, Solomon, Bertiger & Guttilla (RMSB&G). The contract provides for eligible employees of RMSB&G to store 2 units of their own (autologous) frozen blood for future use. [Marketwire]

Chorley Hospital to Introduce Blood Recycling Technology
Blood saving technology has been launched at Chorley hospital. The new high-tech piece of equipment is used to recycle a patient’s blood during surgery. [The Citizen]

Ahli Hospital, Virgin Health Bank Sign Pact
Al-Ahli Hospital recently signed an agreement with Virgin Health Bank on development and banking of cord blood and stem cells. [Gulf Times]

China Cord Blood Corporation Warrant Registration Statement Declared Effective by the Securities and Exchange Commission
China Cord Blood Corporation announced that the Securities and Exchange Commission declared the Company’s registration statement effective on February 9, 2010. [PR Newswire]

POLICY NEWS

Food and Drug Administration Budget Draws Cries of ‘Not Enough’
A coalition of interests will push for more money, saying chronic underfunding has led to failures at the agency and that society, not just companies, are affected. [Food and Drug Administration, United States]

2010 Meeting Materials, Vaccines and Related Biological Products Advisory Committee – Draft Agenda, Member Roster, Posted [Food and Drug Administration, United States]

National Institutes of Health Grants to Children’s Hospital Will Advance Novel Stem Cell Treatments for Blood Disorders
Two large federal grants recently awarded to The Children’s Hospital of Philadelphia will advance the frontiers of research into cellular therapies. [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (Parent F31) (PA-10-108) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships to Promote Diversity in Health-Related Research (Parent F31 – Diversity) (PA-10-109) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (Parent F32) (PA-10-110) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellows (Parent F33) (PA-10-111) [National Institutes of Health, United States]

Delays in Grant Application Submission due to Widespread Winter Storm (NOT-OD-10-061) [National Institutes of Health, United States]

Recovery Act Limited Competition: Program to Enhance National Institutes of Health-Supported Global Health Research Involving Human Subjects (S07) (RFA-OD-10-006) [National Institutes of Health, United States]

Institutional Clinical and Translational Science Award (U54) (RFA-RM-10-001) [National Institutes of Health, United States]

Notice of Intent to Establish a New National Institutes of Health Common Fund Program: Library of Integrated Network-Based Cellular Signatures (LINCS) (NOT-RM-10-002) [National Institutes of Health, United States]

Waivers for Conflicts of Interest for the February 22, 2010 Vaccines and Related Biological Products Advisory Committee Meeting [Center for Biologics Evaluation and Research, United States]

Investigator Initiated Multi-Site Clinical Trials (Collaborative R01) (PAR-10-096) [National Heart, Lung, and Blood Institute, United States]

Expressions of Interest for Membership of the Therapeutic Goods Committee [Therapeutic Goods Administration, Australia]

EVENTS