Cord Blood News Volume 2.25 | Jul 8 2010

Optimized Multiparametric Immunophenotyping of Umbilical Cord Blood Cells by Flow Cytometry
This protocol is the first of its kind to enable a comprehensive investigation of cord blood cellular populations. [Nat Protoc]

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Researchers Identify Factors Behind Blood-Making Stem Cells
A team of researchers has made significant progress in the understanding of blood-producing stem cells. The study led by RIC Chief Executive Officer and Scientific Director, Dr. Guy Sauvageau, identifies factors that control the production of hematopoietic stem cells. [Press release from the Université de Montréal discussing online prepublication in Cell Stem Cell]

Reprogrammed Human Blood Cells Show Promise for Disease Research
Cells from frozen human blood samples can be reprogrammed to an embryonic-stem-cell-like state, according to researchers. [Press release from the Whitehead Institute for Biomedical Research discussing online prepublication in Cell Stem Cell]

CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

An RNAi Screen Identifies Msi2 and Prox1 as Having Opposite Roles in the Regulation of Hematopoietic Stem Cell Activity
In this study, researchers describe an in vivo RNA interference functional genetics approach to evaluate the role of 20 different conserved polarity factors and fate determinants in mouse hematopoietic stem cell activity. [Cell Stem Cell]

Reprogramming of Human Peripheral Blood Cells to Induced Pluripotent Stem Cells (iPSCs)
Here, researchers derived iPSCs from frozen human peripheral blood samples. Some of the iPSCs had rearrangements of the T cell receptor, indicating that T cells can be reprogrammed to pluripotency. [Cell Stem Cell]

Mitigation of Hematologic Radiation Toxicity in Mice Through Pharmacological Quiescence Induced by CDK4/6 Inhibition
Here, using selective and structurally distinct small molecule inhibitors of cyclin-dependent kinase 4 (CDK4) and CDK6, researchers have demonstrated that selective cellular quiescence increases radioresistance of human cell lines in vitro and mice in vivo. [J Clin Invest]

Placenta as a Source of Hematopoietic Stem Cells
Here, researchers describe recent data showing the intrinsic hematopoietic potential and appearance of hematopoietic cells in the mouse and human placenta and probe the biological rationale behind its hematopoietic function. [Trends Mol Med]

Depletion of L3MBTL1 Promotes the Erythroid Differentiation of Human Hematopoietic Progenitor Cells: Possible Role in 20q- Polycythemia Vera
Researchers knocked down L3MBTL1 expression in primary hematopoietic stem/progenitor (i.e. CD34+) cells isolated from human cord blood (using short hairpin RNAs) and observed an enhanced commitment to and acceleration of erythroid differentiation. [Blood]

RapGEF2 is Essential for Embryonic Hematopoiesis but Dispensable for Adult Hematopoiesis
Here, researchers generated RapGEF2 conditional knockout mice and studied its role in embryogenesis, and fetal as well as adult hematopoietic stem cell regulation. [Blood]

An Efficient Approach to Isolation and Characterization of Pre and Post Natal Umbilical Cord Lining Stem Cells for Clinical Applications
Here, researchers efficiently isolate stem cells from a small segment of pre and post natal umbilical cords, and obtain therapeutically relevant amounts of umbilical cord lining stem cells within 3 weeks. [Cell Transplant]

Transplantation of Human Wharton’s Jelly-Derived Stem Cells Alleviates Chemically Induced Liver Fibrosis in Rats
Researchers evaluated the use of Wharton’s jelly stem cells (WJSCs; the major umbilical cord stem cell population) to treat chemically induced liver fibrosis via intraperitoneal injection of thioacetamide. [Cell Transplant]

Synchrony of Telomere Length among Hematopoietic Cells
Researchers examined in newborns’ cord blood the relationships of telomere length in hematopoietic progenitor cells (CD34(+)CD45(-)) with that in T lymphocytes and in granulocytes. [Exp Hematol]

Early Lymphocyte Reconstitution is Associated with Improved Transplant Outcome After Cord Blood Transplantation
Researchers reviewed the records of 40 consecutive cord blood transplantation patients to determine the impact of lymphocyte recovery on transplant outcome. [Cytotherapy]

Communication of Substance P, Calcitonin-Gene-Related Neuropeptides and Chemokine Receptor 4 (CXCR4) in Cord Blood Hematopoietic Stem Cells
Researchers aimed to assess the role of substance P and Calcitonin gene related peptide on CXCR4 levels. [Neuropeptides]

Stem-Cell Furore Erupts
Long-rumbling hostilities between stem-cell researchers in Germany exploded into a blazing public row, after Nature published a critical reanalysis of data from a high-profile 2008 article. [Nature News Press Release]

AmStem Completes $1 Million Bridge Financing to Drive Launch of Cosmeceutical Facial Cream Product SteMixx(TM)
AmStem Corporation, a world leader in stem cell research using stem cells collected ethically from umbilical cords immediately after birth, announced that it has closed on a $1 million bridge financing loan to fund the launch of its flagship product SteMixx,(TM) a cosmeceutical facial cream that uses Human Conditioned Stem Cell Media. [Marketwire]

Cord Blood America Spokesperson to Hold Webinar on How Cord Blood Transplants Work
Cord Blood America, Inc. is pleased to announce that Natalie Curry, the Company’s official spokesperson and medically saved by the first umbilical cord blood collection in the world, will discuss how cord blood transplants work. [PR Newswire]

China Cord Blood Corporation Continuous Support For Cordlife Rights Issue
China Cord Blood Corporation, China’s first and largest cord blood bank operator announced the latest development in relation to the rights issue of Cordlife Limited, an Australian-listed pan Asia cord blood bank operator, with operations in Hong Kong, Singapore,the Philippines, Indonesia and India. [China Cord Blood Corporation Press Release]

Fate Therapeutics Receives Red Herring’s North America 100 Award for Advancing Stem Cell Technology and New Medicines
Fate Therapeutics, Inc. announced that the Company received Red Herring’s North America 100 award, a prestigious list honoring the year’s most promising private and innovative companies from the North American business region. [Fate Therapeutics, Inc. Press Release]

POLICY NEWS

Research Budgets Face Austerity in 2012
The National Institutes of Health and other life sciences and biomedical research funding agencies will need to trim their budgets for 2012, which are to be planned over the summer, to satisfy a White House that is now stressing deficit reduction and belt-tightening after two years of stimulus funding-boosted research budgets. [The Office of Management and Budget, United States]

Strong Medicine for French Research
The medical-research adviser to France’s president aims to shift power and money to universities. [National Research Agency, France]

Meeting of the National Advisory Council for Healthcare Research and Quality [Agency for Healthcare Research and Quality, United States]

Maryland Stem Cell Research Commission – Public Meeting Notice [Maryland Stem Cell Research Commission, United States]

Center for Scientific Review; Notice of Closed Meetings [National Institutes of Health, United States]

Science Board Advisory Committee; Notice of Meeting (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]

Guidance for Industry: Adaptive Design Clinical Trials for Drugs and Biologics [Food and Drug Administration, United States]

Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval Applications (Docket Nos. FDA-2010-M-0068, FDA-2010-M-0078, FDA-2010-M-0063, FDA-2010-M-0135, FDA-2010-M-0158) [Food and Drug Administration, United States]

EVENTS

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

International Society for Cellular Therapy – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

International Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

AABB (formerly known as the American Association of Blood Banks) Annual Meeting & Cellular Therapy and Transfusion Medicine Expo (CTTXPO) 2010
October 9-12, 2010
Baltimore, United States

Institute for Genomic Medicine Inaugural Symposium
October 11-12, 2010
San Diego, United States

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

World Cord Blood Congress
November 4-7, 2010
Marseille, France

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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