SCIENCE NEWS Discovery Suggests Possible Treatment Strategy for Aggressive Leukemias Researchers have identified a protein called Musashi that prevents cells from maturing, creating a large population of immature cells, which is one of the hallmarks of chronic myelogenous leukemia. [Press release from Duke University Medical Center discussing online prepublication in Nature] New Model of Leukemia Sheds Light on Possible Novel Treatment Targets Scientists have created a clever model of how leukemia cells hide in the bone marrow niche and then grow and divide throughout the human body. Researchers figured out a way to create a human to human microenvironment in the laboratory so that they can study the disease process and eventually use the model to test new treatments. [Press release from the Feinstein Institute for Medical Research discussing online prepublication in Tissue Engineering]
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INDUSTRY NEWS Cell Therapeutics, Inc. (CTI) Signs Long-Term Manufacturing Agreement for Pixantrone with NerPharMa Cell Therapeutics (CTI) announced that it has signed a manufacturing agreement with NerPharMa DS for CTI’s drug candidate pixantrone. [Cell Therapeutics, Inc. Press Release] International Stem Cell Corporation and Insight Bioventures Seek to Establish Indian Operations International Stem Cell Corporation (ISCO), and Insight Bioventures India Private Limited, announced that they have signed a letter of intent concerning funding and establishment of an Indian affiliate of ISCO. [International Stem Cell Corporation Press Release] New Research Collaboration to Advance Stem Cell Use North East-based Orla Protein Technologies Ltd., the UK Stem Cell Bank and Newcastle University, have been awarded a grant by the Technology Strategy Board to develop technology which could dramatically improve the way cells are grown in a laboratory. [UK Stem Cell Bank Press Release] Mesoblast Receives TGA Regulatory Approval to Commercially Manufacture Adult Stem Cell Products Australian regenerative medicine company, Mesoblast Limited announced that the Australian Therapeutic Goods Administration (TGA) has issued a license to Mesoblast to manufacture and supply its proprietary Mesenchymal Precursor Cell products. [Mesoblast Limited Press Release] BioTime Announces Addition of New Stem Cell Lines to Its Product Portfolio BioTime, Inc. announced that on August 1, 2010 the Company will be offering for sale 21 new stem cell products for research use only. [Yahoo! Finance] Asuragen and Life Technologies Launch CE-Marked BCR/ABL1 Quant™ Leukemia Test in Europe Asuragen, Inc. and Life Technologies Corporation announced that they have achieved CE-marking and commercial launch in Europe of the BCR/ABL1 Quant™ Test, Asuragen’s clinically validated and cGMP manufactured test intended to aid clinicians in the monitoring and treatment of individuals afflicted with chronic myeloid leukemia. [Asuragen, Inc. Press Release] Prochymal New Drug Submission Granted Priority Review by Health Canada Osiris Therapeutics, Inc. announced that the Biologics and Genetic Therapies Directorate of Health Canada has completed its initial evaluation and accepted for full review the company’s New Drug Submission of Prochymal (remestemcel-L), an adult stem cell therapy for the treatment of graft versus host disease. [Osiris Therapeutics, Inc. Press Release] Kit-Based Cord Blood Program Gives Moms New Options for Donation A new kit-based umbilical cord blood pilot donation program under way at Duke University Medical Center could significantly expand options for mothers who want to donate their baby’s cord blood to a public bank. [Duke University Medical Center Press Release] Key GlycoMimetics Patents Issue in the U.S. GlycoMimetics, Inc. announced that the U. S. Patent and Trademark Office has issued two patents covering the company’s lead drug candidate and related compounds. One patent, U.S. number 7,728,117, specifically covers GMI-1070, the Company’s drug candidate now in clinical trials of patients with vaso-occlusive crisis of sickle cell disease. [GlycoMimetics, Inc. Press Release]
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POLICY NEWS NIH Asks for Input on Closing Loophole in Conflict-of-Interest Rule Responding to yet another flap about the influence of drug companies on biomedical research, the National Institutes of Health (NIH) has decided it needs more time to revise its rules for policing conflicts of interest so that sanctions will move with an investigator if he or she changes institutions. [National Institutes of Health, United States] House Panel Approves 3.2% Raise for NIH in 2011 A House of Representatives spending panel yesterday approved a $1 billion increase, to $32 billion, in the 2011 budget for the National Institutes of Health (NIH). [National Institutes of Health, United States] NIH Expands National Network for Transforming Clinical and Translational Research Nine health research centers have received funds to develop ways to reduce the time it takes for clinical research to become treatments for patients. The funds were awarded as part of the Clinical and Translational Science Awards program which is led by the National Center for Research Resources. [National Institutes of Health, United States] Brussels to Invest $8.3 Billion in Research Research organizations, universities, and industry will receive a sum of EUR6.4 billion next year in the European Commission’s largest ever allocation for research and innovation. [European Commission, European Union] Ireland Keeps Light Shining on Science with New Spending In a surprise move, the Irish government (which is tottering on the brink of bankruptcy) announced that it would inject EUR359 million into research. [Programme for Research in Third-Level Institutions, Ireland] Russian Researchers Call for Better Coordination of Science More than 2200 researchers sent an open letter to Russian President Dmitry Medvedev last week asking the government to set Russian science in order and to consult with the scientific community when making major science-policy decisions. [Russia] ‘Game Over’ for British Science? The Royal Society and the British Academy strongly warned the British government that looming cuts to science funding could be “irreversibly catastrophic for the future of U.K. science and economic growth” if they go too far. [The Royal Society and the British Academy, United Kingdom] Responsibility of Applicants for Promoting Objectivity in Research for Which Public Health Service Funding Is Sought and Responsible Prospective Contractors [Docket Number NIH-2010-0001] [Department of Health and Human Services, United States] Office of Biotechnology Activities; Recombinant DNA Research: Proposed Action Under the NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH Guidelines) (Doc. 2010-17668) [National Institutes of Health, United States] Notice of Intent to Publish a Request for Applications for Tumor Microenvironment Network (TMEN) (NOT-CA-10-032) [National Institutes of Health, United States] Clarification of Additional Research Objectives for NICHD PAR-08-138, Genetic Screens to Enhance Zebrafish Research (R01) (NOT-HD-10-015) [National Institutes of Health, United States] Notice of Expiration of Biomedical Technology Research Resource (PAR-08-259) and Reissuance of Biomedical Technology Research Center (P41)(PAR-10-225) (NOT-RR-10-011) [National Institutes of Health, United States] 2011 NIH Directors New Innovator Award Program (DP2) (RFA-RM-10-009) [National Institutes of Health, United States]
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EVENTS (Listed by Date) NEW Cold Spring Harbor Workshop on Stem Cells July 30-August 5, 2010 Cold Spring Harbor, United States NEW 9th Mount Desert Island Stem Cell Symposium August 6-7, 2010 Salsbury Cove, United States Select Biosciences 3rd Annual Stem Cells Europe Conference August 24-25, 2010 Edinburgh, Scotland Select Biosciences World Biobanking Summit August 24-25, 2010 Edinburgh, Scotland Select Biosciences Inaugural Cellular Therapy Summit August 24-25, 2010 Edinburgh, Scotland International Society for Cellular Therapy – Europe 2nd Regional Meeting September 11-14, 2010 Belgirate, Italy Stem Cells USA & Regenerative Medicine Congress 2010 September 13-15, 2010 Philadelphia, United States Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010 September 15-17, 2010 Sydney, Australia International Society for Hematology and Stem Cells (ISEH) 2010 Meeting September 15-18, 2010 Melbourne, Australia NEW Cellular Therapy of Cancer Symposium – ATTACK Project Meeting September 24-27, 2010 Montpellier, France NEW International Society for Cell and Gene Therapy of Cancer (ISCGT) Congress September 27-29, 2010 Doha, Qatar NEW 5th Annual Meeting of the German Society for Stem Cell Research September 30-October 2, 2010 Lübeck, Germany AABB (formerly known as the American Association of Blood Banks) Annual Meeting & Cellular Therapy and Transfusion Medicine Expo (CTTXPO) 2010 October 9-12, 2010 Baltimore, United States NEW 5th Annual Translational Stem Cell Research Conference October 12-13, 2010 New York City, United States Institute for Genomic Medicine Inaugural Symposium October 11-12, 2010 San Diego, United States Fraunhofer Life Science Symposium Leipzig 2010 October 29-30, 2010 Leipzig, Germany World Cord Blood Congress November 4-7, 2010 Marseille, France Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC) November 12-13, 2010 Tianjin, China NEW The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms November 15-18, 2010 Nara, Japan NEW Stem Cell Network’s 10th Annual Scientific Meeting November, 22-24, 2010 Calgary, Alberta 52nd American Society of Hematology (ASH) Annual Meeting and Exposition December 4-7, 2010 Orlando, United States Select Biosciences 5th Annual Stem Cells World Congress January 24-25, 2011 San Diego, United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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