Cord Blood News Volume 2.28 | Jul 29 2010

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    Cord Blood News 2.28, July 29, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events

    TOP STORY

    Histone Deacetylase Regulates High Mobility Group A2-Targeting MicroRNAs in Human Cord Blood-Derived Multipotent Stem Cell Aging 
    Researchers observed that the cellular senescence of human umbilical cord blood-derived multipotent stem cells caused by inhibition of histone deacetylase activity leads to down-regulation of high mobility group A2 and, on the contrary, to up-regulation of p16INK4A, p21CIP1/WAF1 and p27KIP1. [Cell Mol Life Sci]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    Prevalence and Predictors of Chronic Health Conditions After Hematopoietic Cell Transplantation: A Report from the Bone Marrow Transplant Survivor Study
    The burden of long-term morbidity borne by hematopoietic cell transplantation survivors is substantial, and long-term follow-up of patients who received transplantation is recommended. [Blood]

    Allogeneic Stem Cell Transplantation for Adult Philadelphia Chromosome-Negative Acute Lymphocytic Leukemia: Comparable Survival Rates but Different Risk Factors Between Related and Unrelated Transplantation in First Complete Remission
    Results showed comparable survival rates but different relapse rates, non-relapse mortality rates, and risk factors between related and unrelated allogeneic stem cell transplantations. [Blood]

    Bone Marrow Transplantation Restores Epidermal Basement Membrane Protein Expression and Rescues Epidermolysis Bullosa Model Mice
    Researchers aimed to clarify whether bone marrow transplantation treatment can rescue epidermolysis bullosa caused by defects in keratinocyte structural proteins. [Proc Natl Acad Sci U S A]

    Epigenetic Upregulation of Urokinase Plasminogen Activator Promotes the Tropism of Mesenchymal Stem Cells for Tumor Cells
    Researchers investigated whether histone deacetylation was involved in the repression of urokinase plasminogen activator expression in mesenchymal stem cells derived from umbilical cord blood and bone marrow. [Mol Cancer Res]

    Galectin-3 Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta42 Neurotoxicity In Vitro
    Researchers found that expression and secretion of galectin-3 were up-regulated by amyloid-beta42 exposure in human umbilical cord blood-derived mesenchymal stem cells without cell death. [FEBS Lett]

    Ultrastructural Basis of Enhanced Antitumor Cytotoxicity of Cord Blood-Derived CTLs: A Comparative Analysis with Peripheral Blood and Bone Marrow
    Results provide the comparative analyses of dendritic cells from cord blood, peripheral blood and bone marrow, and suggested that umbilical cord blood-dendritic cells might have better antigen presenting ability leading to increased cytotoxic T lymphocyte (CTL)-mediated antitumor cytotoxicity. [Int J Oncol]

    Human Umbilical Cord Blood-Derived Stromal Cells Prevent Graft Versus Host Disease in Mice Following Haplo-Identical Stem Cell Transplantation
    Results from a graft versus host disease mouse model are in agreement with previous in vitro findings, suggesting that human umbilical cord blood-derived stromal cells possess immunosuppressive properties and may act via influencing dendritic cells and CD4+ regulatory T cells. [Cytotherapy]

    Haploidentical Stem Cell Transplantation as a Salvage Therapy for Cord Blood Engraftment Failure in a Patient with Fanconi Anemia
    Haploidentical hematopoietic stem cell transplantations as primary or secondary sources of stem cells, with appropriate T-cell depletion, may be a readily available option in the absence of HLA-matched related or unrelated donors. [Pediatr Blood Cancer]

    p38 Inhibitor Enhances Growth Inhibition and Death in Gallic Acid-Treated Endothelial Cells
    Researchers investigated the effects of p38 inhibitor on gallic acid-induced calf pulmonary artery endothelial cells and human umbilical vein endothelial cell death in view of reactive oxygen species and glutathione. [Int J Mol Med]

    The Therapeutic Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Alzheimer’s Disease
    Researchers undertook in vitro work to examine the potential impact of human umbilical cord blood-derived mesenchymal stem cell treatment on neuronal loss using a paradigm of cultured hippocampal neurons treated with amyloid-beta peptide. [Neurosci Lett]

    MethoCult_645x110_v01


    INDUSTRY NEWS

    STEMCELL Technologies Applauds Nature Protocol Article Published by Prominent HIV Lab at the Institut Pasteur Citing the Use of RoboSep® to Isolate CD4+ and CD8+ T Cells
    In a recent, high-impact Nature Protocol publication, Asier Sáez-Cirión and his group at the Institut Pasteur standardized the protocol for T cell-based HIV suppression. RoboSep®, the fully automated cell separator from STEMCELL Technologies, was the instrument of choice for cell isolation procedures. [STEMCELL Technologies Inc. Press Release]

    Cleveland LBO Firm Riverside Co. Buys Spanish Cord Blood Bank
    Cleveland, Ohio leveraged buyout firm Riverside Co. has acquired private cord blood bank Celvitae Biomedica S.A. in Madrid, Spain for undisclosed terms. [MedCity News]

    International Stem Cell Plans $10 Million Financing Through European Subsidiary
    International Stem Cell Corporation announced that it had entered into a Memorandum of Understanding with ARG Vermogensverwaltung AG, a German Investment Fund, to create a new European subsidiary to be funded with up to $10 million of capital derived from ARG and other independent sources in Europe. [International Stem Cell Corporation Press Release]

    Sickle Cell Treatment Developed at LA BioMed Enters Phase III Clinical Trial
    An experimental treatment for sickle cell disease developed at the Los Angeles Biomedical Research Institute (LA BioMed) has entered Phase III clinical trials. [Los Angeles Biomedical Research Institute Press Release]

    FDA Grants Orphan Drug Status for Personalized Cancer Vaccine, BiovaxID®, Targeting Mantle Cell Lymphoma
    Biovest International, Inc. announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation to BiovaxID®, Biovest’s personalized cancer vaccine, for a second lymphoma indication: mantle cell lymphoma. [Biovest International, Inc. Press Release]


    POLICY NEWS

    Senate Spending Panel Approves $1 Billion Boost for NIH
    A Senate subcommittee matched President Barack Obama’s request for a $1 billion increase in 2011 for the National Institutes of Health (NIH). That raise would bring the agency’s total budget to $32 billion, or 3.5% above the 2010 level, according to a statement from the Senate appropriations labor, health, and human services subcommittee. [National Institutes of Health, United States]

    NIH Takes on New Role in Fight Against Rare Diseases
    A government program focusing on rare diseases, the Therapeutics for Rare and Neglected Diseases (TRND) program, has launched five pilot projects that are taking the National Institutes of Health in a new direction: developing drugs. TRND will work together with scientists, advocates and others to do the required research and testing on drugs before a compound can be tried in humans in a clinical trial. [National Institutes of Health, United States]

    NIH Asks for Input on Closing Loophole in Conflict-of-Interest Rule
    Responding to yet another flap about the influence of drug companies on biomedical research, the National Institutes of Health (NIH) has decided it needs more time to revise its rules for policing conflicts of interest so that sanctions will move with an investigator if he or she changes institutions. [National Institutes of Health, United States]

    Responsibility of Applicants for Promoting Objectivity in Research for Which Public Health Service Funding Is Sought and Responsible Prospective Contractors [Docket Number NIH-2010-0001] [Department of Health and Human Services, United States]

    National Institute of General Medical Sciences; Notice of Closed Meeting (Doc. 2010-18088) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meeting (Doc. 2010-18052) [National Institutes of Health, United States]

    Instrument Development for Biomedical Applications (R21) (RFA-RR-10-009) [National Institutes of Health, United States]

    Bioengineering Research Partnerships (BRP)[R01] (PAR-10-234) [National Institutes of Health, United States]

    National Institute of Biomedical Imaging and Bioengineering Program Project (P01) Applications (PAR-10-233) [National Institutes of Health, United States]


    EVENTS (Listed by Date)

    Cold Spring Harbor Workshop on Stem Cells
    July 30-August 5, 2010
    Cold Spring Harbor, United States

    9th Mount Desert Island Stem Cell Symposium
    August 6-7, 2010
    Salsbury Cove, United States

    Select Biosciences 3rd Annual Stem Cells Europe Conference
    August 24-25, 2010
    Edinburgh, Scotland

    Select Biosciences World Biobanking Summit
    August 24-25, 2010
    Edinburgh, Scotland

    Select Biosciences Inaugural Cellular Therapy Summit
    August 24-25, 2010
    Edinburgh, Scotland

    International Society for Cellular Therapy – Europe 2nd Regional Meeting
    September 11-14, 2010
    Belgirate, Italy

    Stem Cells USA & Regenerative Medicine Congress 2010
    September 13-15, 2010
    Philadelphia, United States

    Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
    September 15-17, 2010
    Sydney, Australia

    International Society for Hematology and Stem Cells (ISEH) 2010 Meeting
    September 15-18, 2010
    Melbourne, Australia

    Cellular Therapy of Cancer Symposium – ATTACK Project Meeting
    September 24-27, 2010
    Montpellier, France

    International Society for Cell and Gene Therapy of Cancer (ISCGT) Congress
    September 27-29, 2010
    Doha, Qatar

    5th Annual Meeting of the German Society for Stem Cell Research
    September 30-October 2, 2010
    Lübeck, Germany

    AABB (formerly known as the American Association of Blood Banks) Annual Meeting & Cellular Therapy and Transfusion Medicine Expo (CTTXPO) 2010
    October 9-12, 2010
    Baltimore, United States

    Institute for Genomic Medicine Inaugural Symposium
    October 11-12, 2010
    San Diego, United States

    5th Annual Translational Stem Cell Research Conference
    October 12-13, 2010
    New York City, United States

    Fraunhofer Life Science Symposium Leipzig 2010
    October 29-30, 2010
    Leipzig, Germany

    World Cord Blood Congress
    November 4-7, 2010
    Marseille, France

    NEW Cambridge Healthtech Institute’s Inaugural Stem Cells in Drug Discovery and Development
    November 8-9, 2010
    San Diego, United States

    Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
    November 12-13, 2010
    Tianjin, China

    The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
    November 15-18, 2010
    Nara, Japan

    Stem Cell Network’s 10th Annual Scientific Meeting
    November, 22-24, 2010
    Calgary, Alberta

    52nd American Society of Hematology (ASH) Annual Meeting and Exposition
    December 4-7, 2010
    Orlando, United States

    Select Biosciences 5th Annual Stem Cells World Congress
    January 24-25, 2011
    San Diego, United States

    Visit
    our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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